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Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes
Date:6/7/2008

TriLipix in Combination with CRESTOR (rosuvastatin calcium) Demonstrates

Similar Lipid Effects in Patients with Diabetes and Overall Study

Population

SAN FRANCISCO, June 7 /PRNewswire-FirstCall/ -- New data from a sub-group analysis of patients with mixed dyslipidemia and type 2 diabetes that were enrolled in a Phase III study showed that the use of Abbott's investigational TriLipix(TM) (ABT-335) in combination with AstraZeneca's CRESTOR(R) (rosuvastatin calcium), demonstrated similar improvements in LDL "bad" cholesterol, HDL "good" cholesterol and triglycerides compared to the overall study population. These data were presented today at the American Diabetes Association's (ADA) 68th Annual Scientific Sessions in San Francisco.

Abbott evaluated the efficacy and safety of TriLipix in combination with rosuvastatin in a Phase III study of more than 1,400 patients with mixed dyslipidemia. This study, presented at the National Lipid Association annual meeting on May 31, 2008, met its primary endpoints. TriLipix in combination with rosuvastatin significantly improved HDL and triglycerides compared to rosuvastatin alone, and significantly improved LDL compared to TriLipix alone.

Of the patients enrolled in this study, a sub-group of 276 patients were identified as having type 2 diabetes. Data from this sub-group demonstrated that the comprehensive effect of TriLipix in combination with rosuvastatin was similar to that seen in the overall study population. Compared to corresponding monotherapies, patients receiving TriLipix in combination with rosuvastatin had significant decreases in triglycerides and LDL, in addition to clinically meaningful improvements in HDL.

Dyslipidemia affects millions of Americans living with diabetes. These patients often have mixed dyslipidemia, a complex combination of lipid problems commonly characterized by high triglycerides, low HDL and moderately high LDL.

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SOURCE Abbott
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