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Abbott's Market-Leading XIENCE V(R) Shows Increasing Clinical Advantages Over TAXUS(R) Express2(TM)/TAXUS(R) Liberte(TM) Between Two and Three Years
Date:3/29/2009

and a low rate of stent thrombosis from zero to three years, per Academic Research Consortium (ARC) definition of definite/probable stent thrombosis (0.9 percent for XIENCE V and 2.8 percent for TAXUS, p-value=0.27)*. The ARC definitions of stent thrombosis were developed to eliminate variability in the definitions across various drug eluting stent trials.

Event rates based on Kaplan-Meier estimates; p-values are for descriptive purposes only.

"The data from the SPIRIT family of trials continue to prove that XIENCE V is an excellent option for patients. Physicians have embraced this technology, as demonstrated by the market-leading position of XIENCE V around the world," said John Capek, Ph.D., executive vice president, Medical Devices, Abbott. "Our next-generation drug eluting stent in development, XIENCE PRIME, builds upon the outstanding body of clinical evidence from the SPIRIT family of clinical trials, while the new stent design and its delivery system build upon the excellent performance of the VISION cobalt chromium platform, improving deliverability and helping physicians treat difficult lesions."

XIENCE V is the market-leading drug eluting stent platform, with 50 percent share in the United States, and market-leading share around the world.

Abbott's next-generation XIENCE PRIME(TM) Everolimus Eluting Coronary Stent System utilizes the same drug and polymer as Abbott's market-leading XIENCE V stent and builds upon the proven design of the MULTI-LINK(R) family of stents. XIENCE PRIME features a new stent design and delivery system that are designed to make it more flexible for improved deliverability. Abbott plans to make XIENCE PRIME available in an expanded size matrix with lengths up to 38 mm. The company expects to launch XIENCE PRIME in Europe later this year.

About the SPIRIT II Trial

SPIRIT II is a prospective
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SOURCE Abbott
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Related medicine technology :

1. XIENCE(TM) V Drug Eluting Stent from Abbott Outperforms Market-Leading Stent in Reducing Major Adverse Cardiac Events at Two Years
2. Study in JAMA Shows Patients Treated With Abbotts XIENCE(TM) V Drug Eluting Stent Experience Better Outcomes Than Patients Treated With Market-Leading Drug Eluting Stent
3. Circulation Publishes Pivotal Two-Year Results On XIENCE V(TM) Drug Eluting Stent
4. Abbotts XIENCE V(TM) Drug Eluting Stent Outperforms TAXUS(R) in Key Efficacy and Safety Endpoints Out to Two Years
5. Abbotts XIENCE(TM) V Drug Eluting Stent Demonstrates Consistent and Positive Clinical Outcomes Out to Two Years
6. SPIRIT II Explores Long-Term Performance of XIENCE V Stent
7. Abbotts XIENCE(TM) V Everolimus Eluting Coronary Stent Shows Continued Superiority to TAXUS Stent in Reducing Major Adverse Cardiac Events in SPIRIT III Clinical Trial
8. MitraClip(R) Therapy Data Shows Important Clinical Benefit in High Risk Patients With Functional Mitral Regurgitation at 12-Month Follow Up
9. Medgenics Phase I/II Clinical Trial Now Shows EPODURE Continuous Anemia Treatment Lasting 5 Months in Kidney Disease Patients
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