Navigation Links
Abbott's ABT-874 Shows Positive Results for Maintenance of Response in Phase II Psoriasis Study
Date:10/1/2007

Study Data Show Patients with Moderate to Severe Psoriasis Who Responded to Anti-IL-12/23 ABT-874 after 12 Weeks of Treatment, Maintained Response at

24 Weeks

BUENOS AIRES, Argentina, Oct. 1 /PRNewswire-FirstCall/ -- Results from an extension to a Phase II study evaluating the effectiveness of Abbott's (NYSE: ABT) investigational anti-IL-12/23 antibody ABT-874 showed that a majority of patients who initially responded to treatment maintained a high level of response following discontinuation of therapy. In the study, patients who achieved 75 percent improvement in psoriasis signs and symptoms (PASI 75) at 12 weeks stopped receiving ABT-874. At 24 weeks, more than two- thirds of these patients maintained at least 50 percent improvement (PASI 50). The Phase II study, conducted in patients with moderate to severe psoriasis, will be presented at the World Congress of Dermatology in Buenos Aires.

Phase II results presented earlier this year at the Society for Investigative Dermatology (SID) Meeting showed ABT-874 reduced psoriasis symptoms significantly in the majority of patients treated. At 12 weeks, at least 90 percent of patients with moderate to severe psoriasis achieved 75 percent improvement in psoriasis signs and symptoms in all but the lowest dosing groups receiving ABT-874, versus 3 percent of patients receiving placebo. Also, more than half of patients achieved 90 percent improvement, in the same four of five ABT-874 dosing groups, versus 0 percent of those receiving placebo.

"ABT-874 represents a novel approach to treating psoriasis, targeting a part of the inflammatory response that is not addressed by any therapy available today," said Alan Menter, MD, Chair,
'/>"/>

SOURCE Abbott
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Abbotts Investigational Treatment ABT-874 Shows Positive Results in Phase II Psoriasis Study
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
4. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
5. MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
6. Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine
7. Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
8. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
9. CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP
10. New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir
11. First Phase II Short-Term Study on Dapagliflozin Shows Results on Safety, Tolerability and Glycemic Markers in Subjects With Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... , Jan. 23, 2015  Today the U.S. Food and ... for the prevention of serogroup B meningococcal disease ... Pfizer,s vaccine Trumenba®, which received FDA approval in October, ... devastating disease. "I have heard over ...
(Date:1/23/2015)... Iowa , Jan. 23, 2015  The Partnership to Fight Chronic ... health care leaders and a new study analyzing the ... The PFCD is a nationwide coalition working to educate policy makers ... released at the Capitol was focused on how the ...
(Date:1/23/2015)... , Jan. 23, 2015 More than a third ... quarter of those with private insurance, filled a prescription for ... a report in this week,s Morbidity and Mortality Weekly Report ... care providers to treat moderate to severe pain.  They are ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
(Date:1/22/2015)... Deer Path of Huntley -- a BMA affordable assisted living ... p.m. to 4 p.m. on Feb. 13. , The community, which ... with physical disabilities between the ages of 22 and 64. , ... sweetheart-themed karaoke. , For more information about the event or Deer ...
(Date:1/22/2015)... 22, 2015 Woodloch Pines, an all-inclusive ... selected by TripAdvisor as the number one best large hotel ... in the world for their annual Travelers’ Choice Awards. ... . The website is home to millions of unbiased and ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many trendy ... on Facebook, Twitter, and Pinterest. The fans will have an ... lottery every week. , Moreover, the company has extended its ... Angelweddingdress homepage for more information. , Angelweddingdress is ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 A ... issue of experience and person-centeredness in the long-term care ... towards action across the continuum. The paper, “The Power ... Continuum,” engages perspectives and practices of the patient, resident ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 Joan ... and keynote speaker at the upcoming 32nd Annual ... ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , shares ... would have gone undetected if she had not followed ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... Humans see color thanks to cone cells, specialized light-sensing neurons ... eyeball. The actual light-sensing section of these cells is called ... of stacked discs, each about 30 nanometers (billionths of a ... Scientists believe that a better understanding of how and why ...
... an associate professor of epidemiology at Boston University,s Slone ... grants from the National Institutes of Health. The first ... Environmental Health Sciences that will study air pollution and ... women. The second award is for a three-year study ...
... for Molecular Medicine (MDC) Berlin-Buch have found out why ... of the world,s most unusual mammals, feels no pain ... packed in narrow dark burrows where ambient carbon dioxide ... is converted into acid, which continuously activates pain sensors. ...
... "disarray and dysfunction" jeopardize access to medical care ... military families, said the American College of Physicians ... with House and Senate leadership. ACP is ... membership organizationin the United States, representing 132,000 internal ...
... early kidney injuries in people, doctors monitor blood level ... to understand the severity of the injury. Creatinine is ... indication of early damage to vital kidney function. For ... researchers have found that even tiny increases of creatinine ...
... MONDAY, Dec. 19 (HealthDay News) -- ,A new study finds ... one of the most aggressive forms of skin cancer. The ... Cutaneous melanoma is the fifth most commonly diagnosed cancer in ... U.S. women. Incidence of the cancer is increasing, and death ...
Cached Medicine News:Health News:Nanometer-scale growth of cone cells tracked in living human eye 2Health News:Boston University researcher awarded 2 NIH grants 2Health News:MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain 2Health News:MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain 3Health News:Congress' 'disarray' makes it 'likely' that 27 percent Medicare cut will go in effect 2Health News:MU researchers find pet kidney injuries are similar to human kidney injuries 2Health News:Previous Cancer May Up Melanoma Risk 2
Aplicare's disposable 1-ounce pouches are designed for individual application and are ideal for reducing waste. They are used in nursing homes, home healthcare settings, blood banks, laboratories, em...
... disposable 1-ounce pouches are designed for individual ... They are used in nursing homes, home ... and many other hospital departments. This unit ... a mild antiseptic, germicidal and cleansing agent. ...
... a gentle and effective surgical scrub with ... Iodine is known to kill skin surface ... viruses, protozoa and yeasts. It produces a ... patient pre-operative prepping, as well as for ...
... is appropriate for pre-surgical patient preparation ... spray); disinfecting of wounds and burns; ... and abrasions. It also acts as ... and office procedures, providing protection against ...
Medicine Products: