Navigation Links
Abbott and AstraZeneca Announce Selection of Next-Generation Fenofibrate ABT-335 and CRESTOR(R) Fixed-Dose Combination
Date:8/31/2007

First Statin and Fibrate Combination in a Single Pill to Target Three Major

Lipid Components Moves Forward to Next Phase of Development

ABBOTT PARK, Ill. and LONDON, Aug. 31 /PRNewswire-FirstCall/ -- Abbott and AstraZeneca confirmed today they will advance the development of Abbott's next-generation fenofibrate ABT-335 and AstraZeneca's CRESTOR(R) (rosuvastatin calcium) in a fixed-dose combination treatment into Phase III clinical trials. The single pill would target all three major blood lipids -- LDL-C "bad" cholesterol, HDL-C "good" cholesterol, and triglycerides.

ABT-335 is Abbott's next-generation fenofibrate currently in late-stage clinical trials. Based on the significant progress made in the ABT-335 and CRESTOR fixed-dose combination development program, the companies have jointly decided to move forward with this fixed-dose combination therapy. The studies are proceeding on schedule.

"This decision highlights the opportunity for broader treatment in many higher at-risk populations," said Eugene Sun, M.D., vice president, Global Pharmaceutical Clinical Development, Abbott. "We're looking forward to exploring the potential of a combination treatment to address the needs of patients."

"AstraZeneca is committed to continually investigate new treatment options for patients at risk for cardiovascular disease," said James Blasetto M.D., Vice President, Strategic Development, AstraZeneca. "The combination of CRESTOR and ABT-335 may be an important option to help patients with mixed dyslipidemia achieve their treatment goals."

ABT-335 and CRESTOR are both lipid-regulating agents. ABT-335 is an investigational compound that is part of a class of medications called fibrates. Fibrates have been shown to raise HDL-C, reduce triglycerides and moderately lower LDL-C.

CRESTOR is part of a class of medication called statins, which has been shown to significantly reduce LDL-C while raising HDL-C. This combination therapy is b
'/>"/>

SOURCE Abbott
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Three Studies Suggest Abbotts Humira (adalimumab) May Improve Work Productivity in Patients with Rheumatoid Arthritis
2. Abbott Announces Positive Nine-Month Results From the Worlds First Clinical Trial of a Fully Bioabsorbable Drug Eluting Coronary Stent
3. Abbott Announces Continued Positive Results with Xience V Everolimus Eluting Coronary Stent in Spirit Clinical Trials
4. New Analysis of Data Shows Treatment With Abbotts Humira (Adalimumab) Significantly Reduced Disease-Related Hospitalization for Patients with Crohns Disease
5. Abbotts Investigational Treatment ABT-874 Shows Positive Results in Phase II Psoriasis Study
6. Abbott Researchers Focus on New Cutting-Edge Approaches in the Fight Against Cancer
7. Two Abbott Studies Reaffirm Carotid Artery Stenting as a Safe and Effective Treatment to Reduce Risk of Stroke
8. Abbott Announces Positive Six-Month Results From the Worlds First Clinical Trial of a Fully Bioabsorbable Drug-Eluting Coronary Stent
9. Abbotts Xience V Everolimus Eluting Coronary Stent Superior to Taxus Stent in Spirit III U.S. Pivotal Clinical Trial
10. Abbott to Present New Data Across its Vascular Portfolio at the American College of Cardiologys 56th Annual Scientific Session
11. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon Solution, ... advanced memory and analog IC solutions, today announced that ... July 24, 2014, at 7:00 a.m. Pacific Time (10:00 ... for the fiscal 2014 third quarter ended June 30, ... telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time on ...
(Date:7/10/2014)... JORDAN, Utah , July 10, 2014  BC ... solutions, and MiE America , Inc., a leading ... have entered into a long-term agreement naming BC Technical ... the US. MiE and BC Technical ... strategic agreement to establish BC Technical as the service ...
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... ST. LOUIS , Feb. 1 Stereotaxis (Nasdaq: ... featured Dr. Mauricio Arruda , a leading electro-physiologist ... in Cleveland, Ohio , performing a live cardiac ablation ... The patient was a 69 year old woman who suffered ...
... BRISBANE, Calif. , Feb. 1 InterMune, ... Food and Drug Administration,s (FDA) Pulmonary-Allergy Drugs Advisory Committee (PADAC) ... for pirfenidone on March 9, 2010 .  Pirfenidone is ... idiopathic pulmonary fibrosis (IPF).   , "There is an urgent ...
Cached Medicine Technology:Stereotaxis System Procedure Featured on NBC's The TODAY Show 2InterMune to Participate in Pulmonary-Allergy Drugs Advisory Committee Meeting on March 9, 2010 2InterMune to Participate in Pulmonary-Allergy Drugs Advisory Committee Meeting on March 9, 2010 3InterMune to Participate in Pulmonary-Allergy Drugs Advisory Committee Meeting on March 9, 2010 4InterMune to Participate in Pulmonary-Allergy Drugs Advisory Committee Meeting on March 9, 2010 5
(Date:7/10/2014)... HealthDay Reporter THURSDAY, July 10, 2014 ... use of calorie information on menus, if it,s available, to ... U.S. study. Women in particular review the menu labeling, ... with the U.S. Centers for Disease Control and Prevention. ... to help choose their meal, compared with just under half ...
(Date:7/10/2014)... better prepared to respond to an active shooter incident ... study in the journal Prehospital and Disaster Medicine ... the EMS provider comfort level with respect to entering ... neutralized or working with law enforcement personnel during that ... shooting, the Virginia Tech campus shooting, the 2009 Fort ...
(Date:7/10/2014)... with a microchip-based device developed at the Massachusetts General ... MGH Cancer Center can be cultured to establish cell ... the July 11 issue of Science , an ... reflect a tumor,s genetic mutation over time and changing ... culture cells from the blood that represent those present ...
(Date:7/10/2014)... public health concerns in the United States, with 32 ... of 2012. As health problems such as childhood obesity ... discuss the problem. , A new study, led by ... School at Washington University in St. Louis, examined the ... Twitter conversations about the issue of overweight kids. , ...
(Date:7/10/2014)... and Human Services (HHS) has announced a three-year grant ... Center totaling $4.7 million to support a new national ... cancer. , Titled "Evidence-Conformant Oncology Care," the project ... enhance care for adult cancer patients with late-stage disease, ... utilization. , "We believe that the best ...
Breaking Medicine News(10 mins):Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 2Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 3Health News:Active shooter training increases comfort level of emergency responders 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 3Health News:Study looks at how Twitter can be used to address specific health issues 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 3
... has applauded the appeal success of the National ... National Institute for Health and Clinical Excellences (NICE) ... osteoporotic fracture, and has called for continuing efforts ... Guidance is made available. , As an ...
... Methods to identify a patient with a Do Not ... from written documentation practices to the use of color-coded ... of Hospital Medicine, a national effort to standardize color-coded ... status, allergy, fall risk, etc.), would remove current practice ...
... 18, 2007 -- The Association for Professionals ... announced a series of new educational initiatives ... include Clostridium difficile-associated disease and the three ... Medicaid Services (CMS) have classified as preventable ...
... explain why older people are prone to dehydration during ... Older adults don,t drink enough water and become dehydrated ... coordinate sensory signals about thirst, a new Australian study ... signals from the body or the interpretation of these ...
... Tampa, FL (Dec. 18, 2007) -- A University of ... treated in utero a rare but potentially devastating condition ... and can rupture during labor, leaving the baby without ... as vasa previa is frequently deadly for newborns. ...
... 2007) New research published in the December issue ... shows that outcomes of high-risk cancer operations in 80-year-olds ... published survival statistics, which may lead to unrealistic expectations ... With this limited information, elderly patients and their physicians ...
Cached Medicine News:Health News:APIC launches 'Targeting Zero' initiative to eradicate infections deemed preventable by CMS 2Health News:Lack of Strong Thirst Signals Leads Elderly to Drink Too Little 2Health News:Lack of Strong Thirst Signals Leads Elderly to Drink Too Little 3Health News:Fetal surgeon shows for first time that laser procedure may treat vasa previa 2Health News:Fetal surgeon shows for first time that laser procedure may treat vasa previa 3Health News:Study finds outcomes of high-risk cancer operations in 80-year-olds worse than reported 2
...
... Miditron Junior II ... urinalysis analyser for standardised ... hardware and software features ... high performance and convenience ...
... The Assistant Free ... retractors utilizing Velcro® straps. ... of the surgeon's operative ... personnel. Three retractor styles ...
... for four corner fusion of the capitate, ... hand. The plate is intended for use ... of function due to SLAC and SNAC ... rheumatoid arthritis. When combined with the specially ...
Medicine Products: