Navigation Links
AbbVie to Present Data on Investigational Anti-Cancer Compounds at American Society of Clinical Oncology Annual Meeting
Date:5/15/2013

NORTH CHICAGO, Ill., May 15, 2013 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced that data evaluating several investigational compounds in the company's oncology pipeline will be presented at the upcoming 2013 American Society of Clinical Oncology (ASCO) Annual Meeting, May 31 - June 4, Chicago.  Data being presented include the results from two clinical trials evaluating the safety and efficacy of ABT-199, a BCL-2 selective inhibitor, in chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).

Meeting abstracts are available today at http://chicago2013.asco.org/abstracts.

"These presentations further solidify our commitment to addressing the unmet need for new therapies that can improve on current treatment options for patients with cancer," said Gary Gordon , M.D., divisional vice president, oncology clinical development, AbbVie. "With our pioneering research, we are breaking new ground in some of the most widespread and difficult-to-treat cancers."

Presentation Details:

ABT-199

  • Updated Results of a Phase I First-In-Human Study of the BCL-2 Inhibitor ABT-199 (GDC-0199) in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL); J.F. Seymour , et al.; Abstract 7018; Poster Discussion Session; June 1, 2013; 8:00 a.m.-12:00 p.m.
  • Updated Results of a Phase I First-In-Human Study of the BCL-2 Inhibitor ABT-199 (GDC-0199) in Patients with Relapsed/Refractory (R/R) non-Hodgkin's Lymphoma (NHL); M.S. Davids , et al.; Abstract 8520; Oral Presentation; June 3, 2013; 11:30 a.m.-1:30 p.m.

Elotuzumab

  • A Phase I/II Study of Elotuzumab (Elo) plus Lenalidomide/Dexamethasone in Relapsed/Refractory (R/R) Multiple Myeloma: Updated Phase II results and Phase I/II long-term safety; S. Lonial, et al.; Abstract 8542; Poster Discussion Session; June 3, 2013; 1:15 p.m.-5:15 p.m.

ABT-888 (Veliparib)

  • A Phase I Study of Veliparib (ABT-888) in Combination with Carboplatin and Gemcitabine in Subjects with Advanced Solid Tumors; K. M. Bell-McGuinn , et al.; Abstract 2485; Poster Discussion Session; June 3, 2013; 8:00 a.m.-11:45 a.m.

ABT-806

  • A phase I and Biodistribution Study of ABT-806i, an 111 Iindium-Labeled Conjugate of the Tumor-Specific Anti-EGFR Antibody ABT-806; H.K. Gan , et al.; Abstract 2520; Poster Discussion Session; June 4, 2013; 8:00 a.m.-12:30 p.m.

About ABT-199

ABT-199 is a selective inhibitor of B-cell lymphoma-2 (BCL-2) proteins. The B-cell lymphoma 2 gene prevents apoptosis of some cells including lymphocytes, and can be highly expressed in cancers in the lymph nodes, spleen, and other organs of the immune system. As a BH3-mimetic, ABT-199 is designed to block the function of the BCL-2 protein by restoring the communication system that tells cancer cells to self-destruct. Jointly developed by AbbVie and Genentech, the companies are pioneering BCL-2 research with ABT-199, which is currently in Phase 1/1b clinical trials for the treatment of CLL, the most common leukemia in the United States, and several other cancers.

The U.S. Food and Drug Administration (FDA) recently accepted AbbVie's amended clinical trial protocols for studies of ABT-199 in patients with CLL and enrollment for ABT-199 clinical trials in CLL, NHL and multiple myeloma has been re-instated. AbbVie and Genentech expect to move ABT-199 into later-stage clinical trials in the near future. 

About Elotuzumab

Elotuzumab is a humanized monoclonal antibody that targets against CS1, a cell-surface glycoprotein that is highly expressed on multiple myeloma cells. Two Phase 3 studies of elotuzumab in combination with lenalidomide and low-dose dexamethasone at a dose of 10 mg/kg are ongoing in patients with newly-diagnosed (ELOQUENT1) and relapsed/refractory multiple myeloma (ELOQUENT2). Elotuzumab is being jointly developed by AbbVie and Bristol-Myers Squibb.

About ABT-888 (Veliparib)

Veliparib is an investigational oral poly (adenosine diphosphate [ADP]–ribose) polymerases (PARPs) inhibitor being evaluated in multiple tumor types. PARP is a naturally occurring enzyme in the body that repairs damage to DNA, and contributes to chemotherapy resistance in cancer cells. Discovered and developed by AbbVie researchers, ABT-888 (veliparib) is being developed to increase the effectiveness of common DNA-damaging therapies like chemotherapy or radiation. Veliparib is currently being studied in more than a dozen cancers and tumor types, including Phase 2 studies in a variety of cancers, including breast, ovarian, non small-cell lung and gastrointestinal cancers.  

About ABT-806

ABT-806i is an immunoradiopharmaceutical formed by labeling monoclonal antibody ABT‑806 with indium 111 (111In). The antibody portion of the radiopharmaceutical, ABT-806, is a humanized antibody specific for an epitope of EGFR; and epitope that is exposed in deletion variant EGFRde2-7 (EGFRvIII) or when wild-type EGF receptors are amplified, overexpressed, or activated. This epitope provides for the opportunity to use ABT-806i as an imaging agent for the identification and characterization of solid tumor malignancies expressing EGFR, including those expressing deletion variant EGFRde2-7. ABT-806 was in-licensed by AbbVie from Life Science Pharmaceuticals.

About AbbVie Oncology

The fight against cancer is one of the greatest battles in medicine and the varied nature of the disease requires a diverse approach that looks at multiple disease targets in a variety of tumor types. AbbVie's oncology research is focused on the discovery and development of targeted therapies that work against the processes cancers need to survive. By investing in new technologies and approaches, we are breaking ground in some of the most widespread and difficult-to-treat cancers, including multiple myeloma and chronic lymphocytic leukemia. Our oncology pipeline includes multiple new molecules in clinical trials being studied in more than 15 different cancers and tumor types.

About AbbVie

AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. In 2013, AbbVie employs approximately 21,000 people worldwide and markets medicines in more than 170 countries. For further information on the company and its people, portfolio and commitments, please visit www.abbvie.com. Follow @abbvie on Twitter or view careers on our Facebook or LinkedIn page.


'/>"/>
SOURCE AbbVie
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. AbbVie and Alvine to Collaborate on Investigational Oral Therapy for Celiac Disease
2. AbbVie to Present at Bank of America Merrill Lynch 2013 Health Care Conference
3. AbbVies Investigational HCV Regimen Receives Breakthrough Therapy Designation from the U.S. Food and Drug Administration
4. AbbVie CF Scholarship Application Now Available for Exceptional Undergraduate and Graduate Students with Cystic Fibrosis
5. AbbVie Reports First-Quarter 2013 Financial Results
6. AbbVie to Host First-Quarter Earnings Conference Call
7. Receptos Licenses Anti-Interleukin-13 Antibody from AbbVie for Phase 2 Development in Orphan Disease
8. AbbVie to Present at Barclays Global Health Care Conference
9. AbbVie Issues Inaugural Full-Year Outlook for 2013
10. AbbVie Named to S&P 500 Dividend Aristocrat Index
11. Amgen Highlights Data To Be Presented At American Society of Clinical Oncology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2020)... ... ... In response to the COVID-19 pandemic, many companies are sending their employees ... March 15, public schools across at least twenty-nine states have closed, with more states ... are also present. To help working parents adjust to these new and unusual conditions, ...
(Date:3/16/2020)... ... March 16, 2020 , ... The Westat Board of Directors is pleased to ... appointed President and Chief Executive Officer (CEO) effective March 16, 2020, replacing CEO James ... Directors. , “Scott has brought strong leadership, management, and business development acumen to our ...
(Date:3/15/2020)... ... 14, 2020 , ... Dr. Stephen Press of Upper Montclair Dental Associates has ... philosophy of high quality, patient-orientated dental care that always takes place in his warm, ... of his patient’s dental needs, ranging from routine cleanings, to fillings, to bruxism devices. ...
Breaking Medicine Technology:
(Date:3/20/2020)... ... ... My heart goes out to those across our nation and around the world ... through similar circumstances - underlying conditions compounded by a virus – I truly empathize. ... emotions just like many have: fear, anxiety, uncertainty. In contrast, I would like to ...
(Date:3/20/2020)... ... 21, 2020 , ... The Healthcare Compliance Symposium 2020 will ... live discussion and learning online. Experts will provide helpful insight on a variety ... of boards, fraud, waste and abuse, and privacy and security laws while instructing ...
(Date:3/19/2020)... ... 19, 2020 , ... Sucheta Kamath, Founder and CEO of ... Student Learning Exercise: ExQ® Superpower Hour. During the recent closure of ... help with the immediate need for activities that can be implemented at home, ...
(Date:3/19/2020)... ... ... “We wanted to solve the challenges of safely getting testing for COVID-19 in ... reliable at home testing kit that can be processed quickly allows us to give ... their own home, while maintaining the health of the general public." , Members can ...
(Date:3/16/2020)... ... 2020 , ... To avoid the potential spread of coronavirus ... implementing several new universal health and safety measures agency-wide. , "Our top ... Monteic A. Sizer, executive director of Northeast Delta. "Extensive discussion has occurred around ...
Breaking Medicine News(10 mins):