Navigation Links
AbbVie and Galapagos to Co-Develop Cystic Fibrosis Therapies
Date:9/24/2013

NORTH CHICAGO, Ill. and MECHELEN, Belgium, Sept. 24, 2013 /PRNewswire/ -- Galapagos NV (Euronext: GLPG) and AbbVie (NYSE: ABBV) announced today that they have entered into a global alliance to discover, develop and commercialize novel potentiator and combination therapies in cystic fibrosis (CF), an inherited chronic disease that affects 70,000 people worldwide.

AbbVie and Galapagos will work collaboratively to contribute technologies and resources in order to develop and commercialize oral drugs that address the main mutations in CF patients, including F508del and G551D.  The goal of the collaboration is to identify compounds that correct defects in expression of (corrector) and/or increase the activity (potentiator) of the main mutations in the cystic fibrosis transmembrane regulator (CFTR) protein, including the F508del mutation, which is the most common with 90 percent prevalence among patients with CF.

In the alliance, AbbVie and Galapagos will develop potentiators and correctors discovered by Galapagos and expand the range of molecules, with the aim to initiate Phase 1 clinical studies at the end of 2014.  Following successful clinical development and regulatory approval, AbbVie will be responsible for commercial activities, with Galapagos retaining exclusive rights in China and South Korea and co-promotion rights in Belgium, the Netherlands, and Luxembourg.  

Under the terms of the agreement, AbbVie will make an initial upfront payment of $45 million to Galapagos for rights related to the global alliance.  Upon successful completion of pre-determined success milestones, AbbVie and Galapagos will share responsibility and funding for Phase III clinical develo
'/>"/>

SOURCE AbbVie
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. AbbVie Named to S&P 500 Dividend Aristocrat Index
2. AbbVie Issues Inaugural Full-Year Outlook for 2013
3. AbbVie to Present at Barclays Global Health Care Conference
4. Receptos Licenses Anti-Interleukin-13 Antibody from AbbVie for Phase 2 Development in Orphan Disease
5. AbbVie to Host First-Quarter Earnings Conference Call
6. AbbVie Reports First-Quarter 2013 Financial Results
7. AbbVie CF Scholarship Application Now Available for Exceptional Undergraduate and Graduate Students with Cystic Fibrosis
8. AbbVies Investigational HCV Regimen Receives Breakthrough Therapy Designation from the U.S. Food and Drug Administration
9. AbbVie to Present at Bank of America Merrill Lynch 2013 Health Care Conference
10. AbbVie and Alvine to Collaborate on Investigational Oral Therapy for Celiac Disease
11. AbbVie to Present Data on Investigational Anti-Cancer Compounds at American Society of Clinical Oncology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... --  West Pharmaceutical Services, Inc. (NYSE: ... injectable drug administration, announced today it plans to expand ... in Waterford, Ireland . The new ... and other high-value packaging components, in order to meet ... this new site could bring approximately 150 new jobs ...
(Date:10/2/2014)... BOSTON , Oct. 1, 2014   Intarcia ... two of its four phase 3 clinical trials for ... through a matchstick-sized, subcutaneous osmotic mini-pump). The first trial, ... that tested the efficacy and safety of ITCA 650 ... study demonstrated ITCA 650 to be significantly superior to ...
(Date:10/1/2014)... Ohio , Oct. 1, 2014 /PRNewswire/ ... shareholders is now available. Interested parties can learn ... how Cardinal Health is supporting the health ... http://cardinalhealth.com/annualreport . Photo- ... to summary financials and the chief executive ...
Breaking Medicine Technology:West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 2West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 3West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 4West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 5Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 2Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 3Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 4Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 5Cardinal Health 2014 Digital Report to Shareholders Now Available 2
... -- Global Information, Inc. is excited to announce remaining ... scheduled for Boston, MA in the Spring of 2012. ... Drug Design Conference June 6 - ... to arrive at its current mainstream position in medicinal chemistry, ...
... developer of Healthcare Technology Networks ("HTN") designed to improve ... announces the launch of its proprietary Opioid Management Program ... United States Bone & Joint Decade , from ... from musculoskeletal disease filled 1.6 billion prescriptions. While 18.6 ...
Cached Medicine Technology:Boston to Host 3 Major Annual Drug Discovery Conferences, Early Bird Expiring April 27 2Boston to Host 3 Major Annual Drug Discovery Conferences, Early Bird Expiring April 27 3Med-Tek Launches the First Evidenced Based Opioid Management Program (OMP) 2
(Date:10/2/2014)... have pinpointed a molecule that may trigger potentially life-threatening ... say this finding could offer a target for new ... Most asthma attacks (80 percent to 90 percent) are ... the British researchers. Most of these are rhinoviruses, which ... The researchers found that a specific molecule called IL-25 ...
(Date:10/2/2014)... By Dennis Thompson ... -- A newborn,s risk of developing celiac disease isn,t reduced ... found in wheat called gluten to an infant,s diet help ... a pair of new studies in the Oct. 2 ... put to rest hopes that a child could avoid celiac ...
(Date:10/2/2014)... discovery by scientists at The University of Nottingham could ... of painkiller. , A drug resulting from the research, ... would offer new hope to sufferers of chronic pain ... effective painkillers are currently available. , The work, led ... Life Sciences, in collaboration with David Bates, Professor of ...
(Date:10/1/2014)... today in the Journal of the American Medical ... years with moderate or severe chronic knee pain, acupuncture ... University of Melbourne randomly assigned 282 patients (50 years ... or sham or pretend laser treatment. , Treatments ... blinded to laser and sham (inactive) laser acupuncture. , ...
(Date:10/1/2014)... 1, 2014) Despite a policy focus on ... disabilities, this vulnerable population continues to have significant ... The Journal of the American Dental Association , ... Tufts University School of Dental Medicine report on ... at-home oral care provided by caregivers to adults ...
Breaking Medicine News(10 mins):Health News:New Clues to How Colds Can Spur Asthma Attacks 2Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 2Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 3Health News:Medical discovery first step on path to new painkillers 2Health News:Study finds acupuncture does not improve chronic knee pain 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3
... America (GSA) the nation,s largest interdisciplinary organization ... Vishwa Deep Dixit, DVM, PhD, of the Pennington Biomedical ... Shock New Investigator Award. The distinguished honor is ... through basic biological research. It was established in 1986 ...
... The immunochemical fecal occult blood test (iFOBT) is ... not in the upper gastrointestinal (GI) tract, confirms a ... Journal ) (pre-embargo link only) http://www.cmaj.ca/site/embargo/cmaj101248.pdf . ... noninvasive tool to screen for bleeding without symptoms in ...
... Hydrogen sulfide is a foul-smelling gas with an odor resembling ... substance is generally associated with decaying vegetation, sewers and noxious ... it also plays a critical role in protecting blood ... study from the University of Texas Medical Branch at Galveston. ...
... By Denise Mann HealthDay Reporter , TUESDAY, Aug. ... and replace damaged discs -- at least in rats, a ... implants like these, made of cells and collagen, may one day ... They might also last longer than the more artificial replacement ...
... of Nottingham scientist who uses fruit flies to study the ... Research UK. Dr Marios Georgiou, lecturer in cell biology ... a five year Career Establishment Award of 600,000. The award ... to become the eminent cancer scientists of the future. ...
... By Amanda Gardner HealthDay Reporter , MONDAY, ... leading pulmonary associations have issued new guidelines for the ... of the world,s leading killers. While the recommendations ... they differ little from previous guidelines and are meant ...
Cached Medicine News:Health News:Dixit to receive GSA's 2011 Nathan Shock New Investigator Award 2Health News:Noninvasive fecal occult blood test effective screen for lower GI tract lesions 2Health News:Scientists show 'swamp gas' protects blood vessels from complications of diabetes 2Health News:Bio-Engineered Spinal Discs Appear Successful in Rats 2Health News:Bio-Engineered Spinal Discs Appear Successful in Rats 3Health News:Nottingham scientist wins major cancer research award 2Health News:Nottingham scientist wins major cancer research award 3Health News:New Guidelines for Spotting, Treating COPD Released 2
The CH 2000 Cardiac Diagnostic system is a fully featured stress testing system that can include Microvolt T-Wave Alternans (MTWA) testing capability as an add-on feature. , ,Interfaces with Tra...
... The Volk G-1 trabeculum provides the highest ... Perfect for viewing and treating the trabecular meshwork. ... of the anterior chamber angle while the central ... view the posterior pole for signs of glaucoma ...
... The AFX (Air Fluid eXchange) ... lens designed for use in ... to its use as a ... the low profile and sutureless ...
... The 45° Prism ... fundus pathologies and are ... detachments (PDR, BRVO etc.) ... They can be used ...
Medicine Products: