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AbbVie To Present Investigational Data From Phase II Hepatitis C Program At The Liver Meeting
Date:10/1/2013

V Development Program
The AbbVie HCV clinical development program is intended to advance scientific knowledge by investigating an interferon-free, all-oral DAA regimen with the goal of producing high SVR rates in as many patients as possible, including those typically most difficult to cure. The large, multinational HCV program includes more than 2,200 patients from 30 countries.

AbbVie's hepatitis C portfolio includes investigational medicines with three different mechanisms of action targeting areas of the viral replication process including boosted protease inhibitor (ABT-450), polymerase (ABT-333) inhibitor and NS5A (ABT-267) inhibitor, currently being studied in clinical trials. ABT-450/r is co-formulated with ABT-267.

Details of AbbVie's phase III clinical programs are as follows: StudyPatients (n)Treatment RegimenTreatment DurationSAPPHIRE I

GT1, treatment-naïve

(600*)

ABT450/r +ABT267**

ABT333

Ribavirin

12 weeksSAPPHIRE II

GT1, treatment-experienced

(400*)

ABT450/r +ABT267**

ABT333

Ribavirin

12 weeksPEARL II

GT1b, treatment-experienced

(210*)

ABT450/r +ABT267**

ABT333

Ribavirin

12 weeks

SOURCE AbbVie Inc.
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