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AbbVie Presents Preliminary Results from Phase I Study of Investigational Oncology Compound ABT-199/GDC-0199 in Patients with High-Risk Chronic Lymphocytic Leukemia (CLL) at European Hematology Association Annual Meeting
Date:6/17/2013

phoma (MCL) (>10 cm). With a median follow-up of five months (range 0.5-15), 17 patients discontinued: 13 due to progression of disease, two due to AEs and two proceeded to bone marrow transplant in ongoing response.

Of the patients enrolled in this arm of the trial, eight (26%) had MCL, an aggressive, rapidly progressive subtype of NHL that does not respond well to current therapies. Preliminary efficacy results showed that all eight patients (100%) with MCL achieved a partial response. Further clinical studies to evaluate the efficacy and safety of ABT-199/GDC-0199 in MCL are necessary.

About ABT-199/GDC-0199
ABT-199/GDC-0199 is a selective inhibitor of B-cell lymphoma-2 (BCL-2) proteins. The B-cell lymphoma 2 gene prevents apoptosis (death) of some cells including lymphocytes, and can be highly expressed in cancers in the lymph nodes, spleen, and other organs of the immune system. As a BH3-mimetic, ABT-199/GDC-0199 is designed to block the function of the BCL-2 protein by restoring the communication system that tells cancer cells to self-destruct. ABT-199/GDC-0199 is being developed in collaboration with Genentech in the United States and Roche outside the United States. Together, the companies are pioneering BCL-2 research with ABT-199/GDC-0199, which is currently in Phase 1/1b clinical trials for the treatment of CLL and several other cancers.

Enrollment is currently active in ABT-199/GDC-0199 clinical trials in CLL, NHL and multiple myeloma. AbbVie and Genentech expect to move the compound into later-stage clinical trials in the near future. 

About Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia is the second most common leukemia in adults, affecting approximately 124,000 people in the European Union. It is a slow-progressing cancer of the blood and bone marrow in which the bone marrow makes too many lymphocytes, a type of white blood cell that helps th
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