Navigation Links
AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy
Date:5/20/2013

ic.i  

Inclusion criteria for patients includes estimated GFR (another important indicator of kidney disease progression) of 25 to 75 mL/min/1.73 m2, UACR >300 and <5,000 mg/g, and systolic blood pressure within 110 and 160 mgHg.i

The primary endpoint will evaluate the effect of atrasentan on time to doubling of serum creatinine or the onset of ESRD, as defined by need for chronic dialysis, transplant or death due to renal failure. Secondary endpoints will assess the effects of atrasentan on urine albumin excretion, eGFR and cardiovascular events including cardiovascular death, heart attack and stroke.  Quality of life evaluations also will be conducted.i

After initial screening, patients will be enrolled in a run-in period to optimize RAS inhibitor and diuretic doses.  Eligible patients will then enter an enrichment period, in which they will receive atrasentan 0.75 mg/day for six weeks to determine their UACR response and to assess tolerability of atrasentan.  Approximately 3,150 responders (UACR reduction > 30 percent from baseline) and approximately 1,000 non-responders (UACR < 30 percent reduction from baseline) will then be randomized 1:1 into a double-blind treatment period, which will continue for approximately 48 months.i

About Diabetic Nephropathy

Diabetic nephropathy is kidney disease or damage that is a common complication of diabetes.iv Worldwide, approximately 171 million people are living with diabetes and the global burden is expected to double between 2000 and 2030.v Complications add greatly to the already substantial costs of medical care for patients with type 2 diabetes.vi 

In the US, diabetic kidney disease occurs in approximately 40 percent of all patients with diabetes.iii Diabetes is the most common cause of kidney failure or ESR
'/>"/>

SOURCE AbbVie
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. AbbVie Named to S&P 500 Dividend Aristocrat Index
2. AbbVie Issues Inaugural Full-Year Outlook for 2013
3. AbbVie to Present at Barclays Global Health Care Conference
4. Receptos Licenses Anti-Interleukin-13 Antibody from AbbVie for Phase 2 Development in Orphan Disease
5. AbbVie to Host First-Quarter Earnings Conference Call
6. AbbVie Reports First-Quarter 2013 Financial Results
7. AbbVie CF Scholarship Application Now Available for Exceptional Undergraduate and Graduate Students with Cystic Fibrosis
8. AbbVies Investigational HCV Regimen Receives Breakthrough Therapy Designation from the U.S. Food and Drug Administration
9. AbbVie to Present at Bank of America Merrill Lynch 2013 Health Care Conference
10. AbbVie and Alvine to Collaborate on Investigational Oral Therapy for Celiac Disease
11. AbbVie to Present Data on Investigational Anti-Cancer Compounds at American Society of Clinical Oncology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 27, 2015 Research and Markets ( ... "Intraoperative Imaging Market by Type (Intraoperative CT, Intraoperative MRI, ... to their offering. The global intraoperative imaging ... 3.5% from 2014 to 2019 It holds ... number of forces that favor this market. The need ...
(Date:3/31/2015)... , March 31, 2015 ... "Life Science and Chemical Instrumentation Market (Chromatography, Electrophoresis, DNA ... Flow Cytometer, Incubator, Fume Hood, Centrifuge) - Global ... Life Science and Chemical Instrumentation Market is expected ... of 6.9% from 2014 to 2019. ...
(Date:3/31/2015)... March 31, 2015  SCILEX Pharmaceuticals, Inc., a company ... on the treatment of pain, today announced that ITOCHU ... ), a member of ITOCHU Corporation ( Tokyo ... leading sogo shosha (general trading companies) in ... SCILEX.  ICF has worked closely with SCILEX as an ...
Breaking Medicine Technology:Global Intraoperative Imaging (Intraoperative CT, Intraoperative MRI, Intraoperative Ultrasound) Market 2015-2019 2Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 2Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 3Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 4Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 5SCILEX Pharmaceuticals Announces Strategic Investment By ITOCHU CHEMICAL FRONTIER Corporation 2
... May 1 The clinical impact of the first-ever,pro-healing stent, ... at next month,s 16th Annual Scientific Congress of,the Hong Kong ... Sheraton Hong Kong Hotel, the one-hour,session will include:, ... Tse, M.D., of the Hong Kong ...
... Diabetes Association and Richard and Susan Smith Family,Foundation ... ALEXANDRIA, Va., April 30 The American,Diabetes Association ... human type 2 diabetes genes in mice, and ... genetic causes of type 2 diabetes. The,projects will ...
Cached Medicine Technology:Clinical Impact of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) is Subject of Symposium at 16th Annual Scientific Congress of Hong Kong College of Cardiology 2Continued Funding to Help Advance 'Exciting Moment' in Diabetes Research 2
(Date:4/1/2015)... Enterprise Integration has appeared on ... distinguished list and report identifying the world’s top ... list is currently available on the MSPmentor. Additional ... MSPs in North America ,     The top ...     The top MSPs in Asia, Australia and ...
(Date:3/31/2015)... Bon Secours New York Health System ... Nursing Care Center family last week. The Sisters formerly ... Yonkers which is scheduled to close later this year. ... the Sisters of Charity of New York, the decision ... place their Sisters at Schervier Nursing Care Center followed ...
(Date:3/31/2015)... On November 24, 2014, Per Wickstrom had an opportunity ... problem of substance abuse and the solutions that are offered ... and recovery, gives a unique first-person perspective on addiction and ... the New York Giants, Taylor’s early career was almost cut ... he was able to straighten out long enough to make ...
(Date:3/31/2015)... 31, 2015 Over the last several ... technique have yielded better results and more efficient ... and perfected by a good hair transplant surgeon, has ... techniques of hair restoration have improved the efficiency of ... used to add precision and flexibility to the field ...
(Date:3/31/2015)... Dr. Parsa Mohebi, founder of Parsa Mohebi Hair Restoration has ... of using beard hair to fill in balding areas ... has now become an absolute option for giving patients the best ... believe that beard to scalp hair transplant can be a patients ... as dense as we would like it,” says Dr. Parsa Mohebi. ...
Breaking Medicine News(10 mins):Health News:Penton Technology Names Enterprise Integration to the MSPmentor 501 Global Edition 2Health News:Penton Technology Names Enterprise Integration to the MSPmentor 501 Global Edition 3Health News:Bon Secours New York Health System Welcomes Retired Sisters of Charity to the Family 2Health News:Lawrence Taylor & Per Wickstrom Discuss the Drug Rehabilitation & Recovery Process 2Health News:Beverly Hills Hair Transplant Surgeon Now Combines Advanced Robotic Hair Transplantation and Manual Techniques for Greatest Results 2Health News:Is Beard to Scalp Hair Transplant the Future? 2
... researchers have found that Diethanolamine (DEA), an ingredient found ... to interfere with normal brain development in baby mice. ... mice and seemed to have an adverse effect on ... Professor of nutrition in UNC's schools of public health ...
... a tumor suppressor gene which was identified by Professor Sir ... done on this gene using the mice model shows that ... ageing process. Larry Donehower of Baylor College of Medicine in ... they later developed cancer. In another set he modified the ...
... the fatty acid ratio found in the typical Western diet ... of omega-6 fatty acids// may reduce prostate cancer tumor growth ... issue of the journal Clinical Cancer Research, this initial animal-model ... of diet on lowering an inflammatory response known to promote ...
... Evaluation of bone healing can be primarily dome ... formatting as the primary imaging// technique, according to ... University of Vienna in Vienna, Austria. ... fusion) or spinal fusions who'd undergone MDCT and ...
... the Earth Institute, Columbia University, a well-known economist feels ... Schemes// in order to provide better healthcare facilities for ... Mission, India should make a National Health Insurance scheme ... population of the country still living in poverty" he ...
... Farma, the country's biggest vaccine producer, has been awarded a ... Indonesian government.// ,The Agricultural Ministry awarded the ... billion rupiah (US$1.01 million) was the lowest among the bidding ... from China, which could begin within two weeks after the ...
Cached Medicine News:Health News:Altering Fatty Acid Levels in Diet May Reduce Prostate Cancer Growth Rate 2
... Rapid exchange thrombectomy never ... with tortuous anatomy in mind, ... cut shaft, soft tip and ... trackability, and pushability. Glide in ...
... Radiometer's 1st automatic is an automated ... samplers and IT to reduce the steps ... operator safety, and minimize errors. The 1st ... arterial sampler, FLEXLINK software, and FLEXQ automatic ...
... three software components that comprise the ... software components comprise the SmartPill GI ... SmartPill Data Receiver software and SmartPill ... integrated and indispensable parts of the ...
... is the new second-generation application software for ... ,This software release includes a range ... efficiency and userfriendliness. Included are automatic tools ... Blood Indicator (SBI) which highlights images that ...
Medicine Products: