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AVAC Says MDP 301 Microbicide Trial Results Disappointing, but Researchers and 9,400 Trial Volunteers Deserve Praise for Successful Trial
Date:12/14/2009

ribution to HIV prevention research," Warren said. "As we move forward in our search for new HIV prevention options, researchers will need the help of tens of thousands more volunteers around the world. We hope that many more communities and individuals will follow in the footsteps of the MDP 301 trial participants."

While this trial did not result in an effective product, it was a successful trial - it gave a clear result, even if that result is disappointing. In many ways, this trial should serve as a model for future HIV prevention trials as it will provide critical scientific information as well as important lessons from the extensive social science component and the comprehensive community engagement and preparation undertaken by the trial staff. The principal investigators and trial staff developed several innovative integrated approaches for working with participants and communities to ensure retention in the trial and to track women's use of the product.

"The HIV prevention field must now take the lessons learned from this trial and apply those systematically to a rational plan for future microbicide development", said Polly Harrison, Director of the Alliance for Microbicide Development, an AVAC partner. "Such a plan must include broadening the pipeline of candidate microbicides; making strategic decisions about which candidates should go forward in human trials; and ensuring that there is adequate funding for the additional trials that will be needed in the coming years."

Warren and Harrison agree that the entire HIV prevention research field must commit to working together to share knowledge, new information and innovative ideas, and to ensuring that there is coordination across prevention research disciplines and among researchers, implementers and communities.

Today, there are many more HIV prevention options in large-scale trials, including vaccines, other microbicides with different mechanisms of action and
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SOURCE AIDS Vaccine Advocacy Coalition
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