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ARRY-502 Meets Primary And Key Secondary Endpoints In Asthma Study
Date:7/23/2013

RRY-502 is an oral, potent and highly selective CRTh2 antagonist designed to treat patients with allergic asthma.  The CRTh2 receptor is expressed on Th2 T cells, basophils and eosinophils, and its ligand, prostaglandin D2 (PGD2), is released by mast cells.  The results of this study demonstrate that the PGD2/CRTh2 axis plays a key role in the migration and activation of inflammatory cells leading to many symptoms of asthma including coughing, difficulty breathing and exacerbations.  Because current asthma therapies do not fully target the Th2 pathway, antagonism of CRTh2 represents an exciting new approach to enhance disease control. 

Based on its mechanism of action, ARRY-502 may provide the most patient benefit in a Th2 gene signature-enriched population.  Several baseline Th2-related biomarkers were evaluated in the Phase 2 study.  The Th2 gene signature, which is present in about half of the asthma population, spans mild, moderate and severe disease and suggests broad applicability for ARRY-502 in these patients as well as in other Th2-driven diseases like allergic rhinitis and atopic dermatitis. 

About AsthmaIt is estimated that approximately 25 million people in the United States have asthma causing significant morbidity and mortality.  The worldwide estimates are between 235-300 million people with 180,000 deaths annually.  Despite the range of available asthma treatments, there remains a significant need for a convenient, safe and effective therapy for patients.  Specifically, oral medications may provide improved adherence relative to inhaled and injectable therapies. 

About Array BioPharmaArray BioPharma Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array is evolving into a late-stage development company and
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