Navigation Links
ARCALYST® (rilonacept) Meets Primary and All Secondary Endpoints in Second Phase 3 Trial for Prevention of Gout Flares in Patients Initiating Uric Acid-Lowering Therapy
Date:2/28/2011

-related signs and symptoms (7.3% with ARCALYST and 7.3% with placebo), and taking more than the recommended dose (5.6% with ARCALYST and 6.4% with placebo).

About GoutGout is a condition that occurs when the bodily waste product, uric acid, is deposited in the joints and/or soft tissues.  In the joints, these uric acid crystals cause inflammation, which leads to pain, swelling, redness, heat, and stiffness in the joints.  Treatment guidelines recommend that patients with elevated uric acid levels who experience multiple gout attacks each year should receive chronic uric acid-lowering therapy, such as allopurinol.  Allopurinol reduces the production of uric acid in the body to prevent the occurrence of gout attacks with long-term use.  Approximately 750,000 gout patients initiate allopurinol therapy each year.  During the first months of allopurinol therapy while uric acid blood levels are being reduced, the break up of the uric acid crystals can result in stimulation of inflammatory mediators, including interleukin-1 (IL-1), resulting in acute flares of joint pain and inflammation.  Anti-inflammatory therapy with colchicine is sometimes used to help prevent these flares.  However, the side effects associated with colchicine, which include diarrhea, abdominal cramps, nausea, and vomiting, can limit patients' adherence to both colchicine and allopurinol treatment.

Rationale for the Clinical Exploration of Use of ARCALYST® (rilonacept) in the Treatment of GoutInterleukin-1 (IL-1) is a protein secreted by infection-fighting cells in the blood and tissues.  In many cases, IL-1 acts as a messenger to help regulate immune and inflammatory responses by attaching to cell-surface receptors in cells that participate in the body's immune system.  In excess, it can be harmful and has been shown to be a key driver of inflammation in a variety of diseases, including gout.  In gout, uric acid crystals stimu
'/>"/>

SOURCE Regeneron Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Mindray Medical Meets 2010 Product Development Targets and Announces Strong 2011 Pipeline
2. New IonWorks Barracuda Automated Patch Clamp System Meets Need for Affordable, Accelerated Screening of Ligand- & Voltage-Gated Ion Channels Via Direct Electrophysiology Assays
3. US Oncology Meets With Leading Pharmaceutical and Biotech Companies to Design Clinical Trials for the Cancer Fighting Drugs of Tomorrow
4. LEO Pharmas PEP005 Meets Primary Endpoint in Phase III Trial for Pre-Cancerous Skin Condition
5. Poniard Pharmaceuticals Announces Phase 2 Trial of Picoplatin in Metastatic Colorectal Cancer Meets Primary Endpoint and Study Objectives
6. Investigational Sublingual Allergy Immunotherapy Tablet Meets Primary Endpoint in a Study of Adult Subjects With a History of Grass Pollen Allergies
7. Novartis drug Tasigna(R) meets primary endpoint in pivotal trial against Gleevec(R) as first-line treatment in chronic myeloid leukemia patients
8. Intercept Pharmaceuticals FXR Agonist INT-747 Meets Primary Endpoint in a Phase II Clinical Trial in Type 2 Diabetic Patients with Nonalcoholic Fatty Liver Disease
9. Jazz Pharmaceuticals and UCB Announce Second Phase III Study of Sodium Oxybate in Patients With Fibromyalgia Meets Primary Endpoints
10. MADIT-CRT Trial Meets Primary Endpoint
11. VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 22, 2014 Cumberland Pharmaceuticals Inc. (NASDAQ: ... 2014 financial results after the market closes on Tuesday, ... webcast will be held on Tuesday, August 5, 2014, ... To participate in the call, please dial ... A rebroadcast of the teleconference will be available for ...
(Date:7/22/2014)... 22, 2014 The National Space Biomedical Research ... for Space Radiation Research (CSRR) under the leadership of ... Associate Professor of Pharmaceutical Sciences within the University of ... of Radiation Health. She is located in ... team of investigators working across four U.S. institutions, to ...
(Date:7/22/2014)... Resources Group finds that the market for interventional cardiology (IC) ... stagnant at a value of around $80 million through 2022. ... volumes are growing faster in Canada ... United States and Europe . ... penetration of PCI procedures relative to coronary artery bypass graft ...
Breaking Medicine Technology:Cumberland Pharmaceuticals To Announce Second Quarter 2014 Financial Results On August 5, 2014 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 3The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 2The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 3
... Meghan Lopresto, VP, Sales Force Automation Analytics at The ... Vaccines, will be co-presenting their expertise in interactive selling ... in Philadelphia. The conference is a ... and medical affairs professionals to discuss novel approaches to ...
... -- In 2012, Fi Asia-China, Hi & Ni ... food & beverage shows in China, will take ... Shanghai New International Expo Centre (SNIEC), organized by ... ) (Logo: http://www.prnasia.com/sa/2010/04/19/20100419602891.jpg ) ...
Cached Medicine Technology:The CementBloc and Novartis Vaccines to Jointly Present Top Considerations in Interactive Selling at the 11th Annual iPharmaConnect 2Fi Asia-China, Hi & Ni China is Ready for Return on June 2012 in Shanghai 2
(Date:7/22/2014)... of Hematology (ASH) will present the Society,s highest honor, ... in Hematology, to Kanti R. Rai, MD, of the ... for his 50-year career combining landmark clinical leukemia research, ... care. , The Wallace H. Coulter Award for ... who has been a vital contributor to the field ...
(Date:7/22/2014)... Washington DC (PRWEB) July 22, 2014 ... in USA, launched updated payment app for Forte Payment ... credit, debit and ACH payments on iPhone, iPod and ... 2013 and has been recently updated by SIMpalm. This ... support; app is currently supported on iOS 4.3 and ...
(Date:7/22/2014)... American Conference on Lung Cancer (LALCA 2014) will be ... , Lung Cancer is still the leading cause of ... on the success of the previous conferences in Chile, ... discuss the science and advances in the treatment and ... Latin America in particular. , With tobacco being the ...
(Date:7/22/2014)... The Pennsylvania judge overseeing hundreds ... in the Philadelphia Court of Common Pleas won’t ... cases alleging the medication caused plaintiffs to develop ... In an Order dated July 18, 2014, Judge ... certify the matter for an immediate appeal to ...
(Date:7/22/2014)... The market for botulinum neurotoxin (BoNT) ... owing to novel medical indications created and due to ... societies where physical appearance is extremely valued. Although the ... competitors, new companies and technologies are setting ground for ... put the price of 1st-gen products under pressure, only ...
Breaking Medicine News(10 mins):Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 2Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 3Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 4Health News:SIMpalm Launched Updated Forte Mobile Payment App on iPhone and iPad for Its Client 2Health News:SIMpalm Launched Updated Forte Mobile Payment App on iPhone and iPad for Its Client 3Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 4Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 2Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 3Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 4
... Annual Meeting & OTO EXPO of the American Academy of ... meeting of ear, nose, and throat doctors in the world, ... more than 305 scientific research sessions, 594 posters, and several ... a unique opportunity for journalists from around the world to ...
... graduate student Brian Zikmund-Fisher was forced into the toughest choice ... few years or endure a bone marrow transplant that could ... now an assistant professor at the University of Michigan School ... After nine months of blood transfusions, a bone marrow match ...
... By Dennis Thompson HealthDay Reporter , TUESDAY, ... smile. What wasn,t to like about a break in the ... and fun? Now fast-forward to your adult life. What ... Some medical experts think it,s not only a good idea ...
... to indicate a racial disparity in the psychological abuse ... African American seniors could be twice as likely to ... also revealed that African American elders could be up ... the survey results in The Gerontologist, the ...
... there may be a way to predict, based on individual ... the investigational new drug tivozanib. This is possible, the ... a new way of creating animal tumor models that mimic ... these studies, they have found a single biomarker that may ...
... Jewish Health has received a US patent for a ... bubble to deliver an antigen and DNA adjuvant. Chairman ... Health Professor of Medicine Steve Dow, PhD, developed the ... of an infectious organism, generally work fine by themselves. ...
Cached Medicine News:Health News:2010 AAO-HNSF miniseminars: Wednesday, Sept. 29, 2010 2Health News:2010 AAO-HNSF miniseminars: Wednesday, Sept. 29, 2010 3Health News:Doctors need to help patients prepare better for health decisions 2Health News:Doctors need to help patients prepare better for health decisions 3Health News:Adding Recess to the Workday Gains Backers 2Health News:Adding Recess to the Workday Gains Backers 3Health News:Adding Recess to the Workday Gains Backers 4Health News:African-American seniors at twice the risk for mental abuse, 5 times for financial exploitation 2Health News:African-American seniors at twice the risk for mental abuse, 5 times for financial exploitation 3Health News:Novel biomarker may predict response to new VEGF receptor inhibitor 2
For support, strength and control in your interventions, the RunWay Guide Catheter's large lumen and high-performance design represents a new era in guide catheters....
For support, strength and control in your interventions, the RunWay Guide Catheter's large lumen and high-performance design represents a new era in guide catheters....
... 20-year history, the VOYAGER RX Dilatation Catheter ... outcomes. It combines a new low profile, ... shaft,more flexible markers, and short taper balloon ... tortuous anatomy with even greater confidence, opening ...
... developed over Guidants 20-year history, the VOYAGER ... for successful treatment outcomes. It combines a ... a lower profile shaft,more flexible markers, and ... cross tight and tortuous anatomy with even ...
Medicine Products: