Navigation Links
ARCALYST® (rilonacept) Meets Primary and All Secondary Endpoints in Second Phase 3 Trial for Prevention of Gout Flares in Patients Initiating Uric Acid-Lowering Therapy
Date:2/28/2011

r of gout flares and patients receiving the 80 mg dose had a 73% decrease compared to the placebo group (p<0.0001).  

ARCALYST also met all secondary endpoints of the study.  Compared to placebo, treatment with ARCALYST reduced the proportion of patients who experienced at least one gout flare during the study period by 65% for ARCALYST 160 mg (p<0.0001) and by 60% for ARCALYST 80 mg (p=0.0002).  Compared to placebo, treatment with ARCALYST reduced the proportion of patients who experienced two or more flares by 88% for ARCALYST 160 mg (p<0.0001) and by 84% for ARCALYST 80 mg (p<0.0001).

Primary and key secondary endpoint results were as follows:PlaceboARCALYST® (rilonacept) 80 mgARCALYST® (rilonacept) 160 mg n79

80

81Primary endpointMean # of flares per patient (% reduction compared to placebo)1.06

0.29

(73% reduction)

(p<0.0001)

0.21

(80% reduction)
(p<0.0001)Key secondary endpointsProportion of patients with greater than or equal to( 1 flare (% reduction compared to placebo) 46.8%

18.8%

(60% reduction)

(p=0.0002)

16.3%

(65% reduction)

(p<0.0001)Proportion of patients with greater than or equal to( 2 flares (% reduction compared to placebo)31.6%

5.0%

(84% reduction)

(p<0.0001)

3.7%

(88% reduction)

(p<0.0001) One patient did not report flare data and was excluded from efficacy analysesOverall, the cumulative rate of infections was 17.3% in patients treated with ARCALYST 160 mg, 18.8% in patients treated with ARCALYST 80 mg, and 22.8% in placebo patients.  No deaths were reported in this study.

Specific adverse events that occurred at a frequency of at least 5% in any study group were: injection site reaction (19.8% with ARCALYST 160 mg, 8.8% with ARCALYST 80 mg, and 1.3% with placebo), upper respiratory tract infection (9.9% with ARCALYST 16
'/>"/>

SOURCE Regeneron Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Mindray Medical Meets 2010 Product Development Targets and Announces Strong 2011 Pipeline
2. New IonWorks Barracuda Automated Patch Clamp System Meets Need for Affordable, Accelerated Screening of Ligand- & Voltage-Gated Ion Channels Via Direct Electrophysiology Assays
3. US Oncology Meets With Leading Pharmaceutical and Biotech Companies to Design Clinical Trials for the Cancer Fighting Drugs of Tomorrow
4. LEO Pharmas PEP005 Meets Primary Endpoint in Phase III Trial for Pre-Cancerous Skin Condition
5. Poniard Pharmaceuticals Announces Phase 2 Trial of Picoplatin in Metastatic Colorectal Cancer Meets Primary Endpoint and Study Objectives
6. Investigational Sublingual Allergy Immunotherapy Tablet Meets Primary Endpoint in a Study of Adult Subjects With a History of Grass Pollen Allergies
7. Novartis drug Tasigna(R) meets primary endpoint in pivotal trial against Gleevec(R) as first-line treatment in chronic myeloid leukemia patients
8. Intercept Pharmaceuticals FXR Agonist INT-747 Meets Primary Endpoint in a Phase II Clinical Trial in Type 2 Diabetic Patients with Nonalcoholic Fatty Liver Disease
9. Jazz Pharmaceuticals and UCB Announce Second Phase III Study of Sodium Oxybate in Patients With Fibromyalgia Meets Primary Endpoints
10. MADIT-CRT Trial Meets Primary Endpoint
11. VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Aug. 28, 2014 Levi & Korsinsky announces ... the United States District Court for the District of ... who purchased Galectin Therapeutics Inc. ("Galectin" or the "Company") ... 28, 2014. For more information, click here: ... during the Class Period the Company violated federal securities ...
(Date:8/28/2014)... 28, 2014 Nonin Medical, Inc., the inventor ... medical monitoring, today announced that the Food and Drug ... finger pulse oximeter for use in the ... into a telemedicine hub or kiosk through a USB ... pediatric to adult patients. The Model 3231 received EU ...
(Date:8/28/2014)... Oregon , August 28, 2014 ... Research titled, "DNA diagnostics Market (products, applications, techniques, ... Trends, Opportunities, Growth and Forecast, 2013 - 2020," ... reach $19 billion by 2020 registering a CAGR ... to provide accurate diagnosis and cost effectiveness over ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 3
... 2011 Quest Diagnostics Incorporated (NYSE: DGX ... and services, today announced the CE mark and European ... test on the 3M™ Integrated Cycler.  The new test, ... technique to eliminate nucleic-acid sample extraction, a time-consuming process ...
... N.J., Nov. 1, 2011 MedAvante, Inc., the world,s ... of treatments for central nervous system (CNS) disorders, announced ... 2011 Fifty Fastest Growing Companies. NJBIZ, New ... 50 Fastest Growing Companies in celebration of New Jersey,s ...
Cached Medicine Technology:Quest Diagnostics Announces Launch of Simplexa™ Direct Test for Influenza and Respiratory Viruses in Europe 2Quest Diagnostics Announces Launch of Simplexa™ Direct Test for Influenza and Respiratory Viruses in Europe 3MedAvante Is One of NJ's Fastest Growing Companies 2
(Date:8/28/2014)... Skmen.com, one of the most popular suppliers of men’s ... long sleeve sweater dresses and launched a ... unveiled sweater outfits are available at discounted rates, up ... of fact, Skmen.com’s fashionable and quality items have greatly ... company’s experienced tailors are striving to make more incomparable ...
(Date:8/28/2014)... Recently, iFitDress.com, the distinguished wedding dress manufacturer and ... bridesmaid dresses . Included in the new range are ... them are provided at deeply discounted prices, from 22 ... fast and reliable delivery service. All clients from around ... short time. As is commonly noted, international customers have ...
(Date:8/28/2014)... FL (PRWEB) August 28, 2014 ... Recovery Month throughout September. This month will be ... treatment and mental health services. Along with other ... Group is helping to spread the word about ... in 1989, honoring the work of treatment and ...
(Date:8/28/2014)... Arguments between parents may damage their relationships with their ... than 200 families were asked to make daily diary ... day, mothers and fathers rated the quality of their ... days when parents reported conflict and tension in their ... according to the study recently published in the ...
(Date:8/28/2014)... Arbor, MI (PRWEB) August 28, 2014 ... the nation’s leading intraoperative neurophysiology monitoring ("IONM") company, today ... to the position of Chief Executive Officer effective immediately. ... promoted to President and CFO in 2013 and has ... success. , “Bill’s efforts and achievements since joining ...
Breaking Medicine News(10 mins):Health News:Skmen.com: Bestselling Long Sleeve Sweater Dresses Are Offered Online Now 2Health News:New Selection of Chic Bridesmaid Dresses Available at iFitDress.com 2Health News:Millennium Treatment Group Celebrates National Recovery Month 2Health News:Parents' Fights May Strain Bonds With Their Kids 2Health News:Biotronic NeuroNetwork Announces the Promotion of Bill Gecsey to CEO 2
... significantly expand its services, treating up to 24 patients ... ... April 17 Aurora St. Luke,s Medical Center,s,new hyperbaric chamber will ... improve its regional wound care,services., (Photo: http://www.newscom.com/cgi-bin/prnh/20080417/AQTH107 ), ...
... Family Research Council,Action applauds GOP Presidential candidate Senator ... University supporting the pro-life,platform of the Republican Party. ... possible running mates., FRC Action,s Senior Vice ... Senator McCain depict his support for life as ...
... WALTHAM, Mass., April 17 Inverness Medical,Innovations, Inc. ... rapid point-of-care,diagnostic products, today announced that it will ... 24, 2008. The Company will also host a,conference ... that date to,discuss these results and other corporate ...
... improving indoor air quality, COLUMBUS, Ohio, April 17 ... Heating and Cooling is encouraging,Central Ohioans to take steps ... free of harmful pollutants., National Indoor Comfort Week(R), ... relies, and honors the men and,women who keep those ...
... 19 million Americans living with chronic kidney disease (CKD) ... Recent studies have shown that a main source of ... blood phosphate. , Now researchers at Washington University ... high blood phosphate directly stimulates calcification of blood vessels ...
... 17 RESMED INC. (NYSE: RMD ),announced today that ... the third quarter of fiscal year 2008, ended March 31, ... Pacific Time and will,host a conference call to review its ... is scheduled to begin at 1:30 p.m. Pacific Time and,will ...
Cached Medicine News:Health News:Aurora St. Luke's Medical Center Installs the Country's Second-Largest Hyperbaric Chamber 2Health News:Aurora St. Luke's Medical Center Installs the Country's Second-Largest Hyperbaric Chamber 3Health News:Aurora St. Luke's Medical Center Installs the Country's Second-Largest Hyperbaric Chamber 4Health News:Aurora St. Luke's Medical Center Installs the Country's Second-Largest Hyperbaric Chamber 5Health News:Aurora St. Luke's Medical Center Installs the Country's Second-Largest Hyperbaric Chamber 6Health News:FRC Action Praises John McCain's Pro-Life Comments 2Health News:Inverness Medical Innovations Schedules Conference Call for 10:00 a.m. ET April 24, 2008 to Discuss First Quarter 2008 Results 2Health News:National Indoor Comfort Week - A Breath of Fresh Air for Allergy Sufferers 2Health News:Readily available treatment could help prevent heart disease in kidney patients 2Health News:Readily available treatment could help prevent heart disease in kidney patients 3Health News:ResMed to Webcast Third Quarter 2008 Earnings Conference Call 2
Intermittent catheter...
Intermittent catheter...
Intermittent catheter...
Diagnostic and laboratory test reference. Get help with test preparation, interpretation, follow-up, and reimbursement....
Medicine Products: