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ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia
Date:11/6/2007

h patient was hospitalized for cardiovascular of heart failure causes). Moreover, Dr. Carson presented data that the pairing of these two favorable genotypes produces an even greater clinical response than either monotype alone. With this pairing, all-cause mortality was reduced by 41% (p = 0.032), cardiovascular mortality by 48% (p = 0.017), adjudicated time to first cardiovascular or heart failure hospitalizations by respectively 33% (p =0.008) and 45% (p = 0.002), and days hospitalized/patient by 32% (cardiovascular, p =0.012) or 36% (heart failure, p = 0.003). Such patients, termed the "very favorable diplotype," comprising over 40% of the general population, will be the highest priority for treatment with bucindolol.

New Data on Bucindolol in Atrial Fibrillation and Ventricular Arrhythmia

Data from the Phase 3 BEST clinical trial (Presentation #2867) demonstrated a positive effect of bucindolol on clinically important arrhythmic conditions-atrial fibrillation (AF) and life threatening ventricular arrhythmias (VT/VF). In the presentation by Christopher Lowery, M.D. of the University of Colorado, subjects with chronic heart failure (CHF) and Arg/Arg 389 beta-1 or wild type alpha-2c adrenergic receptors treated with bucindolol had a lower rate of new onset AF than those randomized to placebo. This treatment effect was not observed in the population of beta-1 Gly389 or the alpha-2c deletion carriers, indicating a pharmacogenetic interaction. Moreover, the "Very Favorable" diplotype pairing of these two favorable gene variants produced even greater positive treatment effects (reduction by 52%, p = <0.048), similar to the pharmacogenetic findings observed with heart failure endpoints.

As demonstrated in a presentation (Presentation #2021/C32) by William Sauer, M.D. of the University of Colorado, subjects with CHF and Arg/Arg 389 beta-1 or wildtype alpha2c adrenergic receptors treated with bucindolol had a lower rate of VT/VF than those randomized to
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SOURCE ARCA Discovery, Inc.
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