Navigation Links
ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia
Date:11/6/2007

during the trial that examined the effects of bucindolol in beta-1 adrenergic receptor gene variants (beta-1 389 Arg/Arg and Gly carriers).

In the adrenergic receptor genetic substudy, chronic administration of bucindolol resulted in a significant reduction in cardiovascular hospitalizations and mortality. Effects on both were strikingly beta-1 389 Arg/Gly specific, with the higher functioning, Arg/Arg version of the receptor associated with large treatment effects (compared to placebo, reduction in time to event CV hospitalizations by 34% (p = 0.003), CV hospitalizations/patient by 35% (p = 0.005), number of days CV hospitalized/patient by 36% (p = 0.005), and cardiovascular mortality by 46% (p = 0.015)). The presentation concluded that genetic targeting of the beta-1 AR 389 polymorphism may improve the clinical responses to bucindolol for CV mortality and morbidity.

"Effect of b1 389 Arg/Gly a2c 322-325 Wt/Del Genotypes on Adjudicated Hospitalizations in the BEST Trial" (Presentation #2912) presented, in an oral presentation by Dr. Peter Carson of the Virginia Medical Center, data from a recent adjudication by the BEST nine member endpoints committee (EPC), in which they reviewed all 5,086 hospitalizations from the study, recognized by the FDA as an important endpoint in evaluating heart failure drugs.

The analysis revealed that the EPC method -- due to its level of specificity -- adjudicated fewer hospitalizations due to worsening heart failure as compared to the investigator/CRF method. In addition, the EPC adjudication tended to increase effect size, although the CRF method of identifying heart failure hospitalizations yielded similar qualitative results.

The results presented by Dr. Carson demonstrated both the beta-1 389 Arg/Arg adrenergic receptor polymorphism and the alpha-2c wild type gene variant are positively correlated with certain major clinical responses to bucindolol (all-cause mortality, cardiovascular mortality and days eac
'/>"/>

SOURCE ARCA Discovery, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
2. New Company Starts, Bridging the Development Gap in the Discovery of Cancer Drugs
3. Trana Discovery and Southern Research Institute Announce the First RNA-RNA High Throughput Drug Screening Assay Platform for HIV Antivirals
4. ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies
5. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
6. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
7. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
8. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
9. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
10. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
11. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... MENLO PARK, Calif. , July 6, 2015 /PRNewswire/ ... of its 2015 Internal Auditing around the World ... decade, Protiviti has analyzed and reported on the evolution ... select companies from around the globe as a means ... a deeper understanding of this strategic business function. ...
(Date:7/6/2015)... , July 6, 2015 Hologic, Inc. ... plans to release its financial results for the third ... after the market closes.  In conjunction with the release, ... 4:30 p.m. Eastern Time. Interested participants may ... the United States ) or 719-325-4804 (for ...
(Date:7/6/2015)... YORK , July 6, 2015 E-QURE ... Chairman, will present live at VirtualInvestorConferences.com on July 9, ... EDT LINK: http://tinyurl.com/e-qure-presentation This ... are invited to ask the company questions in real-time ... the association,s "virtual trade booth." If attendees are not ...
Breaking Medicine Technology:New Edition of Internal Auditing Around the World from Protiviti Explores Changes and Trends 2Hologic to Announce Financial Results for the Third Quarter of Fiscal 2015 on Wednesday, July 29, 2015 2E-QURE Corp to Webcast, Live, at VirtualInvestorConferences.com July 9 2
(Date:7/6/2015)... ... July 06, 2015 , ... ... year for aesthetic reasons, which is why liposuction regularly ranks among the top ... however, fat reduction has become more than a way to slim down a ...
(Date:7/6/2015)... ... July 06, 2015 , ... ... California, has partnered with Woodbridge Walk-In Urgent Care to offer on-site health screenings. ... serious medical conditions. Screenings are affordable and accurate and run about an hour ...
(Date:7/6/2015)... ... July 06, 2015 , ... MD Now, the leading and fastest-growing urgent care ... urgent care center will serve residents and visitors in the Cutler Bay area, giving ... 22nd South Florida location, the new facility will be the fourth to serve Miami-Dade ...
(Date:7/6/2015)... ... July 06, 2015 , ... Dr. Lawrence Green is now offering ... Kybella is a non-surgical method to dissolve fat cells and is the ... severe fat deposits under the chin, commonly known as a double chin. Dr. Green ...
(Date:7/6/2015)... ... July 06, 2015 , ... The Path of Least Resistance: The Evolution of ... with the U.S. economy over the past 40 years. The book explores the evolution ... ways, the book is a time capsule that chronicles the economic development of the ...
Breaking Medicine News(10 mins):Health News:Learn How CoolSculpting® and Liposuction in Virginia Beach Help Military Members Stay the Course 2Health News:Learn How CoolSculpting® and Liposuction in Virginia Beach Help Military Members Stay the Course 3Health News:Woodbridge Walk-In Offers Affordable Early Detection Health Screenings Through Longevity 2Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 2Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 3Health News:Rockville, MD Practice Now Offering New FDA-Approved Non-Surgical Double Chin Treatment 2Health News:New Book Brings Reveals The Repercussions Associated With The Global Economy 2
... PRINCETON, N.J., Aug. 24 Ranbaxy Pharmaceuticals Inc. (RPI), ... today that RLL has received approval from the U.S. Food ... 1 mg and 2 mg. The Office of Generic ... formulations to be bioequivalent and have the same therapeutic effect ...
... , , ATLANTA, Aug. 24 ... by the American Diabetes Association (ADA), kicks off in Atlanta on ... F earless A frican-Americans C onnected and E ... also supported by Aetna, educates and empowers African-Americans living with diabetes ...
... , , SKILLMAN, N.J., Aug. ... community and hospital care, today announced new data showing that AQUACEL(R) ... an MRI environment. , , AQUACEL(R) Ag dressing ... gelling benefits of ConvaTec,s proprietary Hydrofiber(R) Technology plus the ...
... International Journal of Obesity reports that consumption of ... a key aspect of successful weight maintenance. ... intake, as well as the dietary restraint of over ... use of artificially sweetened beverages may be an important ...
... enough, experts warn , MONDAY, Aug. 24 (HealthDay News) -- ... virus if they believe the risks outweigh the benefits, suggests ... in Vancouver before the start of the current swine flu ... a new vaccine in the event of a pandemic. , ...
... , SAN ANTONIO, Aug. 24 Fall 2009 ... family schedules, which can have a devastating impact on family pets that ... PurinaCare(R) Pet Health Insurance ( www.purinacare.com ), which is committed to help ... all pet owners to be aware of the signs of post-summer ...
Cached Medicine News:Health News:Ranbaxy Receives Final Approval to Manufacture and Market Glycopyrrolate Tablets 2Health News:Grammy(R)-Nominated R&B Sensation Angie Stone Teams up With the American Diabetes Association to Encourage African-Americans to be Victorious in the Face of Diabetes 2Health News:Grammy(R)-Nominated R&B Sensation Angie Stone Teams up With the American Diabetes Association to Encourage African-Americans to be Victorious in the Face of Diabetes 3Health News:Grammy(R)-Nominated R&B Sensation Angie Stone Teams up With the American Diabetes Association to Encourage African-Americans to be Victorious in the Face of Diabetes 4Health News:New Data Demonstrate Magnetic Resonance Safety of AQUACEL(R) Ag Dressing 2Health News:New Data Demonstrate Magnetic Resonance Safety of AQUACEL(R) Ag Dressing 3Health News:New Data Demonstrate Magnetic Resonance Safety of AQUACEL(R) Ag Dressing 4Health News:New research: Consumption of sugar substitutes assists in long-term weight control 2Health News:Not Everyone Wants to Be Vaccinated Against Pandemic Flu 2Health News:Does Your Pet Have Post-Summer Separation Anxiety? 2Health News:Does Your Pet Have Post-Summer Separation Anxiety? 3
Straight shafts with heavy Elschnig teeth. Flat serrated handle with slide style lock and polished finished....
Straight shafts with fine Pierse type tips. Flat smooth handle with dull finish....
Straight shafts with 1 x 2 Elsching style teeth. Wide serrated handle with polished finish....
Straight crisscross serrated tips. Flat handle with holes and polished finish....
Medicine Products: