ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular ... (

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ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia

Date:11/6/2007

- New Data Presented at American Heart Association Scientific Sessions 2007

ORLANDO, Fla., Nov. 6 /PRNewswire/ -- ARCA Discovery, a privately held biopharmaceutical company, announced today that investigators presented new data analyses on ARCA Discovery's lead product candidate bucindolol, a next-generation beta-blocker and vasodilator for heart failure, atrial fibrillation, and arrhythmia, from the Beta-blocker Evaluation of Survival Trial (BEST) at the American Heart Association's (AHA) Scientific Sessions 2007 Orlando, Florida.

"The data presented today provided us with more evidence supporting the potential of bucindolol as a targeted therapy for the treatment of heart failure," said Michael R. Bristow, M.D., Ph.D., chief science and medical officer of ARCA. "Importantly, we are encouraged by the data demonstrating bucindolol's effect in preventing atrial fibrillation and life threatening ventricular arrhythmia, showing the promise for bucindolol in additional indications. In addition, the BEST trial investigators were able to extend the observation of pharmacogenetic targeting of bucindolol to benefits on cardiovascular hospitalizations, which in effect gives the drug and targeting concept a broader application."

"Effects of Bucindolol on Cardiovascular Mortality and Morbidity Determined by the Beta-1 389 Arg/Gly Receptor Polymorphism Data from a sub-study analysis of the BEST cohort" (Presentation #901) presented by Michel White, M.D. from the Montreal Heart Institute, demonstrated for the first time that in the entire 2,708 patient cohort of BEST, chronic administration of bucindolol results in a significant reduction in cardiovascular hospitalizations, as well as in the previously reported heart failure hospitalizations and cardiovascular mortality. In addition, results were reported from the large (1,040 patient) DNA substudy of BEST, a hypothesis-driven, prospectively-designed study initiated
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ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular ...( - New Data Presented at American Hear...),Health