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ANX-201 Demonstrates a Unique Resistance Profile in Preclinical Tests
Date:3/31/2008

ADVENTRX Presents Results at Keystone Symposia HIV Pathogenesis Conference

SAN DIEGO, March 31 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. (Amex: ANX) announced that it presented preclinical results for ANX-201, the Company's broad-spectrum antiviral product candidate at the Keystone Symposia HIV Pathogenesis Conference in Banff, Alberta on March 30, 2008. The preclinical results demonstrate a unique resistance profile for ANX-201 and suggest suppression of resistance to nucleoside reverse transcriptase inhibitors (NRTIs), a commonly used class of drugs to treat HIV. The HIV Pathogenesis Conference is part of the Keystone Symposia Global Health Series, which is supported by the Bill & Melinda Gates Foundation. The poster presentation entitled "The pyrophosphate analogue thiophosphonoformic acid confers a favorable HIV resistance profile," was presented by Shani Waninger, Ph.D., associate director for research and development at ADVENTRX.

ANX-201 (thiophosphonoformic acid) is a pyrophosphate analog and member of a new class of reverse transcriptase inhibitor (RTI) that is being developed to provide benefits for treatment-resistant HIV-infected patients. Foscarnet, the main metabolite of ANX-201, is approved by the FDA for use in immunocompromised patients with CMV retinitis and mucocutaneous acyclovir-resistant HSV infections. However, clinical use of foscarnet is limited, in part due to its intravenous administration and low oral bioavailability. In contrast, in vivo tests have demonstrated increased oral bioavailability of ANX-201, relative to foscarnet, potentially enabling oral delivery.

The preclinical data presented at the conference show that virus selected for resistance to ANX-201 develop genetic muta
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SOURCE ADVENTRX Pharmaceuticals, Inc.
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