Navigation Links
ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients
Date:1/8/2009

Patients treated at the initial dose in an ongoing Phase Ib trial demonstrated a 2.5 log10 median viral load decline after three days

Conference Call Today at 8:30AM EST

SAN DIEGO, Jan. 8 /PRNewswire-FirstCall/ -- Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS) today announced results from the first cohort of an ongoing Phase Ib clinical trial of ANA598, the Company's investigational non-nucleoside polymerase inhibitor. ANA598 was very well-tolerated and demonstrated potent antiviral activity in patients infected with chronic Hepatitis C virus (HCV) in this first cohort of the study.

Patients in the first cohort received 200 mg ANA598 (n=8) or placebo (n=2), twice-daily (bid) for three days. At the end of the treatment period, the median viral load decline was 2.5 log10 (>99%), with a range of 1.4-3.4 log10, for the eight patients who received ANA598. Three patients who received ANA598 were genotype 1a and demonstrated a median viral load decline of 1.6 log10, while five patients who received ANA598 were genotype 1b and demonstrated a median viral load decline of 2.6 log10. All eight patients who received ANA598 demonstrated a rapid decline in viral load, and no patients demonstrated viral rebound while on study drug. In addition to the robust viral load decline, ANA598 was very well-tolerated and there were no serious adverse events in the first dose cohort, although conclusions regarding longer-term safety and tolerability cannot be made until the results of future clinical trials of longer duration in more patients are known. Patients are currently being enrolled in the second cohort (400 mg bid) of the study. Anadys expects to report detailed data from multiple cohorts of the study at an upcoming medical conference.

"We are very pleased with the antiviral activity and safety of ANA598
'/>"/>

SOURCE Anadys Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
2. Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
3. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
4. Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598
5. Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients
6. Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers
7. Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors
8. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
9. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
10. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
11. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... A lot of discussion in the medical community revolves ... injuries, or conditions. As medical science advances, doctors and surgeons ... that they consider to be more cutting edge. Yet, when ... method of treatment that stands out as the best solution ...
(Date:1/23/2015)... 23, 2015  MedScope ( www.medscope.org ), the leading provider ... 2015 Connected World magazine Connected World Award ... that can be used anywhere, anytime. The nomination was ... In nominating MedScope, Landon Garner , Director ...
(Date:1/23/2015)... Fla. , Jan. 23, 2015  HyGreen, Inc., a ... agreement and partnership with RCA Medical, a subsidiary of ... . Each year, hundreds of millions ... care-associated infections as organisms are transmitted from patient to ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
... , WASHINGTON, Dec. 14 ... on global and domestic communications and issues management, today ... Corporation (Nasdaq: PSID ) to serve as the ... conduct media relations for PositiveID,s corporate communications and advise ...
... , CLAREMONT, Calif., Dec. 14 The Roberts Environmental ... analysis of social responsibility reporting for the 26 largest ... Pacific Sustainability Index (PSI) scores evaluating the environmental and ... the transparency, intent, and performance for both environmental and ...
Cached Medicine Technology:Gibraltar Associates Named Agency of Record for Health Information and Diagnostic Provider PositiveID Corporation 2New Report Grades Sustainability Reporting of Top Pharmaceutical Companies 2New Report Grades Sustainability Reporting of Top Pharmaceutical Companies 3
(Date:1/22/2015)... 2015 Recently, Weddingshe.com has added many trendy ... announced its highest annual revenues in the past three years. ... glamorous wedding dresses. , According to the sales manager of ... promotions for them in 2015. This point can be reflected ...
(Date:1/22/2015)... Four years since the release of their debut recording ... marriage of Avasa & Matthew Love – the duo are pleased ... release through White Swan Records on February 24, 2015. , THE ... path available to all of us to walk out of the ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and ... relationship in an effort to further promote visibility and adoption ... has long made AMA journals available via its subscription services, ... JAMA Network. , Long known as both a ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store for ... its latest collection of wedding dresses , and launches ... is the wedding dress on your big day; the wedding ... Every bride wants to find the most suitable wedding dress. ...
(Date:1/22/2015)... released a new blog post explaining the importance of keeping a ... of an auto insurance policy . , Clients who driver ... their vehicle insurance policies. The safety a vehicle offers from its ... of this, drivers should always carry a first aid kit in ...
Breaking Medicine News(10 mins):Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... The American Academy of Family Physicians today announced the ... first alliance partner, The Coca-Cola Company. , (Logo: ... is a program that allows corporate partners like The ... consumers about the role their products can play in ...
... are not addressing the main differences between neighborhood food ... or reduce obesity, according to a new RAND Corporation study. ... Angeles region has no more fast-food chain establishments on a ... rather many more small food stores and other food outlets. ...
... The founders of HEAL Africa ( www.hea ... nonprofit organization that provides holistic healing including urgent care medical services ... of Congo, are conducting a seven-city tour of the U.S. to ... of war in Congo. HEAL Africa,s approach to healing conflict has ...
... ,Symphony of the Superhero, to Feature DJ Cut Chemist, Violinist ... Boychoir, Whittier Elementary Choir, The Raretones and Bells of the ... The Symphony Guild today announced ... the Superhero, an annual event which benefits Seattle ...
... in some, but effects were fleeting, scientists say , MONDAY, ... addicts beat their habit is showing some effect but is ... one-third of participants in a new study developed desired immune ... cocaine use did go down. But the effects were only ...
... ... competitive advantage , ... (PRWEB) October 5, 2009-- BodyMedia, Inc. , the pioneer in developing wearable body monitoring ... Ki Performance. Through the company,s first strategic partner in Europe, BodyMedia is extending its ...
Cached Medicine News:Health News:The American Academy of Family Physicians Launches Consumer Alliance With First Partner: The Coca-Cola Company 2Health News:The American Academy of Family Physicians Launches Consumer Alliance With First Partner: The Coca-Cola Company 3Health News:The American Academy of Family Physicians Launches Consumer Alliance With First Partner: The Coca-Cola Company 4Health News:Los Angeles fast-food restaurant ban unlikely to cut obesity, study finds 2Health News:Los Angeles fast-food restaurant ban unlikely to cut obesity, study finds 3Health News:HEAL Africa's Founders Conduct Nationwide Tour to Share Best Practices for Rebuilding Congo 2Health News:HEAL Africa's Founders Conduct Nationwide Tour to Share Best Practices for Rebuilding Congo 3Health News:The Symphony Guild Announces Artist Lineup for 2009 Event 2Health News:The Symphony Guild Announces Artist Lineup for 2009 Event 3Health News:Cocaine Addiction Vaccine Shows Some Success 2Health News:Cocaine Addiction Vaccine Shows Some Success 3Health News:BodyMedia, Inc. Expands Overseas Offerings and Receives Milestone Certification for Continued Global Growth 2Health News:BodyMedia, Inc. Expands Overseas Offerings and Receives Milestone Certification for Continued Global Growth 3
... heterodimeric proteins that suppress the secretion of ... Inhibin consists of two distinct chains, or ... A consists of the alpha-subunit and betaA-subunit. ... betaB-subunit. Only the dimeric forms of the ...
... Pregnancy-associated plasma protein A (PAPP-A) ... PAPP-A is produced in high concentrations ... released into the maternal circulation in ... [1]. PAPP-A is not specific to ...
... peptide encoded by the ob gene and is ... play a key role in the regulation of ... [1,2]. Leptin functions as a lipostat and is ... stores. Increased serum leptin levels signal the brain ...
ACTIVATED CLOTTING TIME SYSTEM...
Medicine Products: