Navigation Links
ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients
Date:4/23/2009

s retains worldwide rights to ANA598, which was fully discovered at the Company. Preclinical evaluation of ANA598 was completed in the first quarter of 2008, leading to submission of an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA), subsequent allowance of the IND by the FDA and initiation of clinical investigation in the second quarter of 2008. In December 2008, Anadys announced that the FDA granted fast track designation to ANA598 for the treatment of chronic HCV.

In October 2008, Anadys initiated patient dosing in the Phase Ib study of ANA598 in HCV patients and in February 2009 Anadys initiated dosing in a 14 day study in healthy volunteers.

In an earlier Phase I study in healthy volunteers, ANA598 was administered as capsules at single oral doses of 400 mg, 800 mg, 1400 mg, 2000 mg (fed and fasted) and 3000 mg. In addition, a separate cohort received two 800 mg doses 12 hours apart. ANA598 was well tolerated at all doses and there were no serious adverse events or withdrawals from the study. All reported adverse events were classified as mild or moderate, with no apparent dose relationship. The pharmacokinetic profile demonstrated sustained plasma levels of ANA598 consistent with the potential for once-daily or twice-daily oral dosing.

In the preclinical program, ANA598 was well tolerated at all doses tested in 28-day GLP toxicology studies. In September 2008, Anadys initiated long-term, chronic toxicology studies of ANA598.

If ANA598 is successful in early stage development, the Company anticipates completion of the clinical, toxicology and manufacturing activities required to initiate Phase II studies of ANA598 in combination with current standard of care in mid-2009.

Clinical Need and Market Opportunity in HCV Infection

Chronic HCV infection is a serious public health concern affecting ap
'/>"/>

SOURCE Anadys Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients
2. Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers
3. Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients
4. Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598
5. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
6. Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
7. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
8. Study Demonstrates Restylane(R) Effect Lasted 18 Months in 97% of Patients With One Repeat Injection
9. Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells
10. Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia
11. Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... , Aug. 29, 2014 Medina Medical announced ... and member of the Board of Directors on August ... device development and commercialization experience, including over a decade ... previously served as a Partner of the medical device ... CEO of two Foundry start-ups. Mr. Engelson previously served ...
(Date:8/29/2014)... DUBLIN , Aug. 29, 2014 ... the "Global Peptide Cancer Therapeutics Market & Pipeline ... The conventional methods developed to prevent and eradicate ... cancer treatment. These methods are confined to low specificity, ... the researchers to look for a better solution. It ...
(Date:8/29/2014)... 29, 2014 Research and Markets ... Development Trend Forecast of Pharmaceutical Equipment Market in China, ... Research and Development Trend Forecast of Pharmaceutical Equipment Market ... China,s pharmaceutical equipment industry in ... competition landscape, and business performance of domestic major enterprises, ...
Breaking Medicine Technology:Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
(Date:8/31/2014)... September 01, 2014 Recently, BambooIndustry.com, one of ... website with a new selection of bamboo veneers . ... 25 percent off) for these high quality products. The promotion ... company’s senior spokesman says that its top quality veneers are ... unveil the new designs of bamboo veneers. All these items ...
(Date:8/31/2014)... In order to celebrate the coming of autumn, Guangdong ... and launched a big promotion. Now, all the global clients ... company’s new cars are made with great materials. FODAY Automobile ... As a matter of fact, it is providing big discounts ... in need of cheap cars can visit its website for ...
(Date:8/31/2014)... 1Heart Caregiver Services Director for Business Development ... Tee Barr conducted a brain fitness education lecture at ... Ayala and Social Services designee Lily are both appreciative ... fitness session. , Research studies have found that cognitive ... of dementia and memory loss. The six essential areas ...
(Date:8/31/2014)... Louis (PRWEB) August 31, 2014 Twin to ... twins Aiden and Blake Colp before they were born, but an ... Institute gave them the chance at life. , Now, their ... and the life-saving fetal surgery option available in St. Louis at ... awareness nights at Market Pub House (6655 Delmar Blvd, St ...
(Date:8/31/2014)... Ticket Down is a dependable source for authentic ... in suburban Denver. The Mexican national soccer team ... teams on USA soil. , Prior to ... aboard, Miguel Herrera, and he has had excellent results with ... in Brazil, the Mexican team played quite well and continued ...
Breaking Medicine News(10 mins):Health News:High Quality Bamboo Veneers from Bambooindustry.com Receive International Attention 2Health News:1Heart Caregiver Services Director Randy Neil Clarito Brings Brain Fitness Education to Victoria Care Center Ventura 2Health News:1Heart Caregiver Services Director Randy Neil Clarito Brings Brain Fitness Education to Victoria Care Center Ventura 3Health News:1Heart Caregiver Services Director Randy Neil Clarito Brings Brain Fitness Education to Victoria Care Center Ventura 4Health News:After a Rare Diagnosis Threatened Their Boys’ Lives, Parents Build Awareness About TTTS and Fetal Surgery Options at The SSM St. Louis Fetal Care Institute. 2Health News:After a Rare Diagnosis Threatened Their Boys’ Lives, Parents Build Awareness About TTTS and Fetal Surgery Options at The SSM St. Louis Fetal Care Institute. 3Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 3
... , TUESDAY, Dec. 7 (HealthDay News) -- Stool tests that ... patients on a low-dose aspirin regimen, which is known to ... therapeutic aspirin use was once feared to skew the results ... the test was significantly more sensitive for low-dose aspirin users ...
... be a life saver for patients needing immediate care. ... process of activating them often delays treatment beyond recommended ... in Annals of Emergency Medicine, was led ... retrospective chart review, McMullan found that a majority of ...
... In an effort to pinpoint potential triggers leading to inflammatory ... close look at the immune system of people living in ... people have steadily grown to outnumber rates of depression in ... of a loss of healthy bacteria. In an article ...
... Occlusion Summit and Left Main Coronary Interventions Course ... findings and new developments in therapeutic procedures essential ... total coronary occlusions and left main coronary interventions. ... When and why to open a chronic total ...
... HealthDay Reporter , TUESDAY, Dec. 7 (HealthDay News) ... the best way to help such veterans stop smoking, a ... researchers randomly assigned 943 smokers with PTSD from their wartime ... and its participants were referred to a VA smoking ...
... By Ellin Holohan HealthDay Reporter , TUESDAY, ... become rampant in the United States, with emergency departments ... injuries, safety experts reported Tuesday. As more children ... suffering an ever-increasing number of injuries, the experts from ...
Cached Medicine News:Health News:Low-Dose Aspirin Boosts Accuracy of Colon Cancer Test 2Health News:Low-Dose Aspirin Boosts Accuracy of Colon Cancer Test 3Health News:Even with helicopter EMS, hospital transfer can delay treatment for heart attacks 2Health News:Even with helicopter EMS, hospital transfer can delay treatment for heart attacks 3Health News:CTO Summit & Left Main Coronary Interventions Course to be held Feb. 14-16, 2011, in NYC 2Health News:Treating PTSD and Smoking Together Best Way to Help Vets Kick Cigarettes 2Health News:Treating PTSD and Smoking Together Best Way to Help Vets Kick Cigarettes 3Health News:Youth Sports Injuries Reaching Epidemic Levels, Experts Report 2Health News:Youth Sports Injuries Reaching Epidemic Levels, Experts Report 3
Straight shafts with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Colibri style tips. Double toothed tips with 0.10 mm teeth spaced 1 mm apart and 7 mm tying platform. Wide serrated handle with polished finish....
Straight shafts with teeth and 6 mm crisscross serrated tying surfaces. Serrated handle with polished finish....
Serrated, 10 mm tips angled 30 degrees. Serrated cross action handle with polished finish....
Medicine Products: