Navigation Links
ANA598 Demonstrates Positive 4-Week Results at 200 mg BID
Date:12/17/2009

NA598 remain susceptible to current SOC, consistent with prior in vitro results.

Anadys has completed two long-term chronic toxicology studies of ANA598 (26 weeks duration in rats and 39 weeks duration in monkeys). The No Observed Adverse Effect Level, or NOAEL, is 1000 mg/kg, the highest dose tested, in both the rat and monkey. The completed toxicology studies support the ongoing Phase II clinical study as well as future clinical studies of longer duration.

Anadys has presented in vitro data supporting the use of ANA598 in combination with interferon-alpha as well as with direct antivirals currently in development. In particular, data has shown that ANA598 is synergistic in vitro with interferon-alpha as well as representative HCV protease and polymerase inhibitors. In vitro combination treatment at clinically relevant concentrations of interferon-alpha and ANA598 results in clearance of HCV RNA from cells rather than selection of resistant isolates. Furthermore, ANA598 retains full activity in vitro against mutations conferring resistance to protease inhibitors, nucleoside polymerase inhibitors and non-nucleoside polymerase inhibitors that act at binding sites distinct from that of ANA598, and protease and nucleoside polymerase inhibitors retain full activity in vitro against mutations conferring resistance to ANA598.

ANA598 has received Fast Track Status from the FDA for the treatment of chronic hepatitis C.

Conference Call Webcast and Slides

Anadys will host a conference call today, December 17, 2009 at 8:30 a.m. Eastern Standard Time (5:30 a.m. Pacific Standard Time) to discuss the 4-week results from the first cohort of the ongoing Phase II clinical trial of ANA598 in combination with SOC. A live webcast of the call, including accompanying slides, will be available online at

SOURCE Anadys Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
2. Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
3. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
4. Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598
5. Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients
6. Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers
7. ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients
8. ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients
9. Anadys Pharmaceuticals Commences Dosing in Phase II Study of ANA598
10. Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors
11. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 The spinal column ... the human body. Signals carried to and from the brain ... skills and nervous system. Injury or ailment here can be ... with a loss of control over their body. Though back ... a person,s life, there are more options available to make ...
(Date:8/21/2014)... N.C. , Aug. 21, 2014 /PRNewswire-iReach/ -- ... Medical Equipment, Inc. for the third straight year, ... Inc. 500|5000, an exclusive ranking of the nation,s ... comprehensive look at the most important segment of ... Pandora, Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, and ...
(Date:8/21/2014)... , August 21, 2014 ... subsidiary, BreedIT Ltd., the exclusive worldwide license holder ... for plant breeders and researchers, today is pleased ... joint venture with Seach Ltd, a leading Israeli ... to research and develop new breeds of medical ...
Breaking Medicine Technology:Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... SAN DIEGO , June 18 Naviscan,s Positron Emission Mammography ... Society of Nuclear Medicine Annual Meeting in Salt Lake City . ... play an important role in the fight against breast cancer.   , ... PEM scanners are high-resolution breast ...
... 17 The chairman of the U.S. bishops, Committee on ... Administration (FDA) over its move toward approving a new drug that ... June 17 letter to Dr. Margaret Hamburg , Commissioner ... - Houston criticized the FDA,s move to hold an advisory ...
Cached Medicine Technology:Naviscan Positron Emission Mammography Technology Highlighted at the Society of Nuclear Medicine Annual Meeting 2Pro-Life Chair Voices 'Grave Concern' over FDA Plan to Approve Abortion Drug for 'Emergency Contraception' 2Pro-Life Chair Voices 'Grave Concern' over FDA Plan to Approve Abortion Drug for 'Emergency Contraception' 3Pro-Life Chair Voices 'Grave Concern' over FDA Plan to Approve Abortion Drug for 'Emergency Contraception' 4
(Date:8/23/2014)... August 23, 2014 GranuFlo lawsuit ... GranuFlo and NaturaLyte dialysis concentrate recall continue to ... U.S. District Court, District of Massachusetts, Bernstein Liebhard ... issued by the U.S. Judicial Panel on Multidistrict ... claims are pending in the proceeding. In July, ...
(Date:8/23/2014)... August 23, 2014 A team of New ... last longer when preceded by surgery and delivered by an ... the new study. Click here to read it now ... the cases of mesothelioma patients who underwent hemithoracic ... radiotherapy dose to the shape of a tumor. Patients ...
(Date:8/23/2014)... The MPWMD Board of Directors voted on Monday, August ... source of water for commercial and industrial properties. This ... of Archworks, LLC in Carmel, California. , This is ... water district in the State of California has approved this ... at this time can now be used as a sole ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 Youth substance ... Texas. It’s no different in Houston, TX. Substance abuse ... falling victim to drug and alcohol dependency in higher ... looking to beat substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
(Date:8/22/2014)... August 23, 2014 The IT manager ... reseller hosting for several years. He has recently announced ... best hosting suppliers in 2014. , GoDaddy is a ... rich features and great hosting solutions at affordable rates. ... price for shared hosting plans depend on the length ...
Breaking Medicine News(10 mins):Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 4Health News:New Study Links Hospital Experience and Prior Surgery with Mesothelioma Radiation Success, According to Surviving Mesothelioma 2Health News:Historical Moment in the Monterey Peninsula, Brings Drought Relief Solution to California, with the Help of EcoloBlue and AWG Technology 2Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2
... oropharyngeal cancer -- a type of cancer that develops in ... assists with breathing, talking, eating, chewing, and swallowing -- are ... of chemotherapy is usually based on the need for radiotherapy ... cells from the original site to other parts of the ...
... of California, San Diego (UCSD) School of Medicine – ... to self-report adverse effects of statin drug use, or ... of research is important because many physicians and other ... the benefits of statins and other cholesterol drugs, but ...
... seems to be the goal of Austrian activists, who are ... build a veritable case for redressal. The data so gathered ... agenda for the city officials to kick start strategies that ... earlier initiative in May had seen activists garnering support by ...
... mandatory heart testing that will follow a standardized screening ... death of Atlanta Hawks center Jason Collier, NBA has ... the future. The mandated tests will include the gamut ... echocardiogram and a stress echocardiogram. ,The NBA ...
... KINGSTON, Ont. –Terminally-ill patients in Canada are not ... concerning resuscitation after a heart attack //or other ... Medicine Daren Heyland. A national study has found ... prepared regarding the different options available to turn ...
... hold sway on the degree of hangover one might experience, ... found. //Scottish researchers delved into this arena, and studied the ... clever lot benefit by being hangover less as compared to ... discomfort associated with a hangover, characterized by an unbearable headache, ...
Cached Medicine News:Health News:Is Radiation or Chemoradiation Best for Oropharyngeal Cancer Patients 2Health News:Is Radiation or Chemoradiation Best for Oropharyngeal Cancer Patients 3Health News:Patients Can Report Statins' Adverse Effects on New Web Site 2Health News:Critically Ill patients ill-equipped to handle end-of life matters 2
... Eye care in the 21st ... flexibility. The Alcon® UltraScan® imaging ... system targeted at clinical echographic ... Easy-to-use software, permits step-by-step processing ...
... Micro-Incision Cataract Surgery (MICS) Is ... unique double-step hexagonal shape, the ... for MICS. The consistently sharp-edged ... allow you to obtain accurate ...
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Infusion Cannula, 6.0mm....
Medicine Products: