Navigation Links
ANA598 Demonstrates Positive 4-Week Results at 200 mg BID
Date:12/17/2009

3.7 3.9

No patient experienced viral rebound (defined as >1 log10 increase from a prior measurement) through week 4. In accordance with the study protocol, four patients (three genotype 1a patients receiving placebo plus SOC and one genotype 1b patient receiving ANA598 plus SOC) discontinued either ANA598 or placebo at week 4 due to failing to reach at least 1 log10 viral load decline.

Preliminary Safety Assessment

Safety and tolerability from the interim analysis appeared similar between the active and placebo arms, with reported adverse events generally typical for interferon and ribavirin, although conclusions regarding longer-term safety and tolerability cannot be made until additional results over longer duration from this trial and future clinical trials in more patients are known. There were no discontinuations due to adverse events. Eight patients reported rash through the interim analysis date, seven mild and one moderate. For the six of twenty-nine patients (21%) receiving ANA598 plus SOC who reported rash, all cases were mild. For the two of fifteen patients (13%) receiving placebo plus SOC who reported rash, one case was mild and one case was moderate. There were no clinically meaningful changes in safety laboratory values and no changes in safety monitoring were recommended by the DMC in association with escalation to 400 mg bid.

Phase II Combination Study

In the ongoing Phase II study, treatment-naïve genotype 1 patients are to receive ANA598 or placebo in combination with Pegasys® (peginterferon alfa-2a) and Copegus® (ribavirin, USP) for 12 weeks at dose levels of 200 mg or 400 mg both given twice daily (bid), each with a loading dose of 800 mg bid on day one. After week 12, patients are to continue receiving SOC. Patients who achieve undetectable levels of virus at weeks 4 and 12 will be randomized to stop all treatment at week 24 or 48.
'/>"/>

SOURCE Anadys Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
2. Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
3. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
4. Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598
5. Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients
6. Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers
7. ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients
8. ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients
9. Anadys Pharmaceuticals Commences Dosing in Phase II Study of ANA598
10. Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors
11. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... , May 29, 2015 A six-hour certification ... is being presented at the Cannabis World Congress & ... New York, NY .  Taking place on Wednesday, ... dedicated day of education at the leading event on the ... Led by Clover Leaf University, the first cannabis ...
(Date:5/29/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hgs483/cardiovascular ) ... report "Cardiovascular Drug Delivery - Technologies, Markets ... Drug delivery to the cardiovascular system is different ... anatomy and physiology of the vascular system; it ... the body. Drugs can be introduced into the ...
(Date:5/29/2015)... , May 29, 2015 ... announced the addition of the "Surgical/Operating Microscopes ... Forecast to 2020" report to their offering. ... global surgical microscopes market is poised to reach ... 2014, at a CAGR of 12.3% from 2015 ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 2Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 3Surgical/Operating Microscopes Market by Application & End User - Global Forecast to 2020 for the $806 Million Industry 2
... , Jan. 27 Warner Chilcott plc ... complete response letter from the U.S. Food and Drug Administration (FDA) ... for its "low dose" oral contraceptive (also referred to as WC ... the third-party drug substance manufacturing facility and control testing laboratory used ...
... GREENSBORO, N.C. , Jan. 27 ... state-of-the-art CT and MR imaging systems to physician practices, ... into agreements with NeuIsys to plan, install, and service ... (CT) System. , Joining the NeuIsys family of ...
Cached Medicine Technology:FDA Issues Complete Response Letter for Low Dose Oral Contraceptive 2FDA Issues Complete Response Letter for Low Dose Oral Contraceptive 3NeuIsys Announces Entrance into the Gastroenterology Market 2
(Date:5/29/2015)... Dot Hill can mark one more item off her ... Prince Woods retirement community is the oldest woman to have ... “It was great fun!”, she exclaimed. “I’ve always wanted to ... so they thought this would be ok.” , “We put on ... tunnel,” she described. “I don’t remember it being noisy, but ...
(Date:5/29/2015)... Tennessee (PRWEB) May 29, 2015 Jan Wooden ... belief in one thing above all else: God does no ... the subject of her son’s passing is titled “God Does ... person is confronted with great personal tragedy. , “My ... losing someone dear to you into something productive, something healing,” ...
(Date:5/29/2015)... 2015 A group of doctors have discovered ... national effort to teach this “new math” to children in ... been “sickened” by the recent implementation of Common Core Math ... it, Common Core is now a reality in children’s classrooms ... are now seeking ways to improve common core math training ...
(Date:5/29/2015)... 29, 2015 The print component of ... circulation of approximately 250,000 and an estimated readership of ... vast social media strategy, and across a network of ... digital version of the campaign, click here. ... publication. Inside, the actress, model and producer details her ...
(Date:5/29/2015)... Chicago, Ill (PRWEB) May 29, 2015 ... Care , a dozen medical pioneers recognized by a ... changed the course of cancer treatment. Honorees will be ... of Cancer Care™ Award Ceremony, held 8:30-11:00 p.m. CDT ... , The 2015 honorees are being recognized for groundbreaking ...
Breaking Medicine News(10 mins):Health News:Indoor Skydiving Brings Thrills to Seniors 2Health News:Turning grief from a child’s passing into virtue 2Health News:Doctors Discover a Cure for the Common Core 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 3Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 4
... , , FRIENDSWOOD, Texas, ... which develops, manages and owns faith-based senior living facilities, today announced ... Inc. for the development of a new senior living facility in ... Heights , an 82-unit, $10 million senior living facility, should be ...
... , COLORADO SPRINGS, Colo., July 28 University ... Military Tuition Grant for university students serving on active duty in ... National Guard and reserves, who pursue a master,s or doctoral degree ... Active Duty Military Tuition Grant offers the following benefits, effective with ...
... , , SAN DIEGO, ... San Diego based medical device company, today announced that F. ... its Board of Directors. , , ... following graduation from San Diego State University in 1961. He ...
... , BATON ROUGE, La. and ALEXANDRIA, Va., ... Rx Access announced today the launch of the Together Rx Access(R) ... immediate and meaningful savings on prescription medicines and products right at ... collaboration will use existing State outreach channels to identify additional uninsured ...
... , BEDFORD, Mass., July 28 ... (Nasdaq: HOLX ), a leading developer, manufacturer and ... dedicated to serving the healthcare needs of women, today announced ... for women suffering from excessive menstrual bleeding--has passed the one ...
... , , , ... (pronounced ah-sigh-EE) has become America,s new super fruit of choice due ... of acai juice can contain a large amount of natural sugar, ... Healthy Balance line of Fit for Your Lifestyle(TM) ...
Cached Medicine News:Health News:TrinityCare Senior Living Announces Funding Agreement for Fifth Senior Living Facility 2Health News:TrinityCare Senior Living Announces Funding Agreement for Fifth Senior Living Facility 3Health News:TrinityCare Senior Living Announces Funding Agreement for Fifth Senior Living Facility 4Health News:University of the Rockies Introduces Military Tuition Grant 2Health News:F. Duwaine Townsen Joins SpectraScience Board of Directors 2Health News:F. Duwaine Townsen Joins SpectraScience Board of Directors 3Health News:F. Duwaine Townsen Joins SpectraScience Board of Directors 4Health News:The State of Louisiana and Together Rx Access Join Forces to Improve Prescription Access for Uninsured Residents 2Health News:The State of Louisiana and Together Rx Access Join Forces to Improve Prescription Access for Uninsured Residents 3Health News:The State of Louisiana and Together Rx Access Join Forces to Improve Prescription Access for Uninsured Residents 4Health News:Photos: One Million Patients Choose Hologic's NovaSure(R) System Over Hysterectomy 2Health News:Photos: One Million Patients Choose Hologic's NovaSure(R) System Over Hysterectomy 3Health News:Photos: One Million Patients Choose Hologic's NovaSure(R) System Over Hysterectomy 4Health News:Photos: One Million Patients Choose Hologic's NovaSure(R) System Over Hysterectomy 5Health News:Old Orchard Brands Introduces Low-Sugar Acai Juice Blend 2
... third-generation immunoassay system combines continuous ... processing with a broad testing ... higher volume clinical laboratories to ... tests simultaneously, as well as ...
Architect i2000 is a flexible solution for your evolving laboratory providing high throughput and walkaway time with built-in flexibility....
The ADx system uses fluorescence polarization immunoassay technology for the detection of abused drugs and toxicology assays....
... The Bayer Immuno 1 provides ... immunoassay instrument with over 50 ... endocrinology, tumor marker, therapeutic drug, ... can be performed on a ...
Medicine Products: