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AMD Alliance, Representing AMD Patient Organizations Globally, Encourages Health Care Providers to Stop Using Avastin for Off-Label Ocular Use
Date:10/19/2011

8;115:1911–1915
  • Austria (8 cases of severe eye inflammation were reported): Georgopoulos et al, Characteristics of severe intraocular inflammation following intravitreal injection of bevacizumab (Avastin). British Journal of Ophthalmology, 2009;93(4):457-462
  • Germany (5 cases of severe eye inflammation reported):  Statement available at http://wissen.spiegel.de/wissen/image/show.html?did=60666870&aref=image038/2008/09/27/ROSP200804001400141.PDF&thumb=false
  • Canada (105 cases of severe eye inflammation): Health Canada requested label update on Avastin to include warnings on unlicensed intravitreal use available at http://ophthalmologyrounds.ca/modules/contentManager/upload/document/alwaysOnLine/ScientificUpdate_en.pdf
  • China (61 cases of eye infection reported): Reported at http://www.chinadaily.com.cn/china/2010-09/24/content_11340951.htm
  • U.S. (12 cases of eye infection reported: FDA warning available at http://www.fda.gov/Drugs/DrugSafety/ucm270296.htm

  • (ii) FDA Alerts Health Care Professionals of Infection Risk from Repackaged AvastinIntravitreal Injections. Available at http://www.fda.gov/Drugs/DrugSafety/ucm270296.htm

    (iii) US Department of Veterans Affairs public statement.


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