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ALS Therapy Development Institute Partners with Clinical Centers to Establish Pathological Mechanisms of Lou Gehrig's Disease
Date:8/19/2008

ncidence rate is similar to that of multiple sclerosis, but the typical survival prognosis given to an ALS new patient is only 2-5 years from the date of diagnosis. Currently there is no known cure for ALS and only one FDA-approved drug, with marginal efficacy, for treating the disease.

The data analysis from this developing translational database has already begun and will be compared with the ALS TDI transcriptome database for the SOD1 mouse collected last year. To date, the Institute has cataloged and analyzed the world's largest collection of information on the molecular changes in the leading mouse model in the effort to establish the fundamental pathological mechanisms of this devastating disease. These ongoing projects are made possible as part of a major, three-year, $18 million funding and scientific collaboration with the Muscular Dystrophy Association (MDA) and its Augie's Quest Initiative, entered into at the beginning of 2007.

"We're pleased to be part of this project that gives our patients an opportunity to participate in very significant research. By collaborating with ALS TDI, a broad spectrum of people living with ALS are now involved in the creation of therapeutics," said Stanley Appel, M.D., co-founder & co-director of the Methodist Neurological Institute in Houston, Texas.

At the time of this announcement, ALS TDI had three clinical locations set up to collect blood donations and clinical information from ALS patients; Methodist Neurological Institute, University of California - Irvine, and Mount Sinai Medical Center. Mount Sinai has approved both blood and muscle tissue collection protocols. All three of these clinics are MDA/ALS Centers. ALS TDI plans to continue to accelerate its biomarker program and has submitted several additional protocols for review and approval to hospitals and clinics in other parts of the U.S. ALS patients and others interested in learning more are encouraged to contact, Beth Levine, Senior Associ
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SOURCE ALS Therapy Development Institute
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