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ALS TDI Completes Gene Expression Profile of Lou Gehrig's Disease in Mice
Date:10/2/2007

there are several more hurdles to overcome and milestones to be reached."

Unprecedented in scale, the gene-expression profiling project is a cornerstone of the ALS TDI research plan. The collaboration was made possible in part by funding received earlier this year as part of a historic three- year, $36 million partnership with the Muscular Dystrophy Association (MDA) through its fast-track ALS research initiative, Augie's Quest.

"This is the first step in an extensive plan to map fully all of the gene and protein changes that lead to the disease," said Sharon Hesterlee, Ph.D., vice president of translational research at the Muscular Dystrophy Association. "As the data are analyzed and the results published, we think this project will greatly benefit the field."

Ultimately, the Institute plans to make this gene-profiling dataset many times larger, and to incorporate information from other neurodegenerative animal models. It has already initiated relationships with several ALS clinics to conduct similar experiments on samples donated by ALS patients.

About ALS Therapy Development Institute

The ALS Therapy Development Institute (http://www.als.net), based in Cambridge, Mass., was founded in 1999 as the ALS Therapy Development Foundation. Re-named in 2007 as a result of its collaboration with MDA's Augie's Quest, the Institute continues its mission to discover and develop drugs to treat ALS. It excels in identifying novel disease targets, discovering compounds that may act against these targets, and screening these potential treatments toward bringing viable therapeutics to the clinic.

About Augie's Quest

Fitness pioneer Augie Nieto started Augie's Quest (http://www.augiesquest.org) in conjunction with MDA's ALS Division. Nieto is co-founder and former president of Life Fitness of Chicago, and chairman of Octane Fitness. He and
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SOURCE ALS Therapy Development Institute
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