Navigation Links
ALS TDI Completes Gene Expression Profile of Lou Gehrig's Disease in Mice
Date:10/2/2007

Largest Target-Discovery Program Aimed at New Treatments for Fatal Disease

CAMBRIDGE, Mass., Oct. 2 /PRNewswire/ -- The ALS Therapy Development Institute (ALS TDI) today announced that it has completed the first phase of a comprehensive gene-expression database for ALS with the profiling of the SOD1 mouse model of amyotrophic lateral sclerosis -- ALS, or Lou Gehrig's disease. The second phase, profiling of human samples, is scheduled for completion by February of 2008. This study is part of the largest known target-discovery program aimed at developing new treatments for the fatal neuromuscular disease.

"This dataset is the foundation that will enable scientists at ALS TDI to understand the biological mechanisms associated with disease progression," said Steve Perrin, Ph.D., chief scientific officer at ALS TDI. "Additional gene expression profiling and proteomics analysis from other mouse models of neurodegeneration, as well as human samples collected at ALS clinics, will help us focus on the most relevant biological pathways to target for drug development."

The gene-profiling study involved looking at which genes are turned on over a period of time in various tissues of the SOD1 mouse. Comprising more than 250 samples from four different tissues, the comprehensive database reflects gene expression from eight time points during disease onset and progression. Scientists at Gene Logic Inc., of Gaithersburg, Md., isolated total RNA from the tissue samples, generated high quality genomic data using the Affymetrix GeneChip(R), and used their expert bioanalytical capabilities to identify the activated genes implicated in ALS.

"The assembly of this data set is an important milestone. We could not have gotten to this point without the critical support of Congressman Capuano, Senator Kennedy, the Department of Defense, the MDA and the nearly 250 families that have invested in our unique approach," said Sean Scott, president of ALS TDI, "However,
'/>"/>

SOURCE ALS Therapy Development Institute
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Lev Pharmaceuticals Completes Phase III Prophylaxis Trial of C1-Esterase Inhibitor for Hereditary Angioedema
2. Celsion Completes Enrollment in Phase I Liver Cancer Study
3. LANI completes Phase I in Japan and to commence Phase I in UK
4. Ace Biosciences, Ace393, the Worlds First Commercial Vaccine for Travellers Diarrhoea Caused by Campylobacter Successfully Completes Phase I Clinical Trials
5. Inovio Biomedicals DNA Delivery Technology Shows Safety and Enhances Gene Expression & Tumor Responses in Interim Melanoma Clinical Study Results
6. Abraxis BioScience Presents Pre-Clinical Findings That Support Role of SPARC Expression in Cancer and the Role of the Nanoparticle Albumin Bound (nab) Technology Platform in Targeting the Pathway
7. Expression Genetics, Inc. Announces Successful Completion of Phase I Trial of Gene-Based IL-12 for Treatment of Ovarian Cancer
8. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
9. Phase IIIb Clinical Data Validate the Overall and Cardiovascular Safety Profile of Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) in Patients with Type 2 Diabetes
10. Kosan Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Epothilone KOS-1584 at ASCO
11. Antipsychotic Iloperidone Results Show Favorable Akathisia Profile
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... , Jan. 14, 2014 HeartWare International, Inc ... of less invasive, miniaturized circulatory support technologies that are ... that it expects revenues for the fourth quarter of ... 2013 revenues to approximately $208 million. "Our ...
(Date:1/14/2014)... 14, 2014 InformEx, North America,s ... chemistry, will hold the 30 th edition of its ... Convention Center from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ... pharmaceutical, fine chemical and specialty chemical companies will take part ...
(Date:1/14/2014)... 14, 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio ... acquired Progressive Home Medical Equipment, Inc. ("Progressive") of ... of the acquisition were not disclosed. Progressive ... a wide range of sleep, mobility, and respiratory products to ...
Breaking Medicine Technology:HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3
(Date:7/10/2014)... says the human brain operates much the same whether ... provide a better understanding of schizophrenia, bipolar disorder and ... 13.6 million Americans. , In newly published research in ... professor at the Center for Molecular and Behavioral Neuroscience, ... at rest is basically the same as that of ...
(Date:7/10/2014)... localized prostate cancer were more likely to be ... effective treatments and survived for shorter times than ... UCLA study has found. , The negative outcomes ... as bias against the mentally ill, depression,s impact ... of investment in his general health and disinterest ...
(Date:7/10/2014)... cakes that are just as tempting as full-fat ... to fresh insights into how proteins can replace ... , Funded by the Engineering and Physical Sciences ... and the University of Edinburgh has produced modified ... therefore closely mimic the behaviour of fats during ...
(Date:7/10/2014)... 10, 2014) Men who experience hot flashes are ... find relief from their silent suffering if they ... findings from a Baylor University case study., After seven ... had uncontrolled hot flashes following prostate cancer surgery showed ... also an impressive improvement in sleep quality, according to ...
(Date:7/9/2014)... The World Health Organization recommends that youth participate in ... physical activity (MVPA) each day. Studies have shown ... hours. Therefore, it stands to reason that increasing ... In a new study scheduled for publication in The ... spent outdoors after school was positively associated with MVPA. ...
Breaking Medicine News(10 mins):Health News:Working to loosen the grip of severe mental illness 2Health News:Depressed men with prostate cancer are diagnosed later stage, get less effective therapies 2Health News:Great tasting low-fat cheeses and cakes could soon be on the menu 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 3Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 4Health News:Go play outside! Outdoor time promotes physical activity in youth 2
... are cutting their transportation costs and reducing delivery times, as a ... customs processes. , ... Jericho, NY (Vocus) May 29, ... cutting their transportation costs and reducing delivery times, as a result ...
... Clinicians, researchers and scientists from around the world ... (DDW ), the largest and most prestigious gastroenterology ... the McCormick Place Convention Center, Chicago, IL. DDW is ... Institute, the largest and oldest GI society in the ...
... ProperSAN FRANCISCO, May 28 The following is a statement ... is a complete vindication for Blue Shield of California. ... It means that our underwriting procedures were fair and ... faith. There was no post-claims underwriting. The evidence ...
... to announce the introduction of the new Multi-Gas Plus ... These cartridges are unique because they do not ... can be used to work in environments up to ... OSHA guidelines are followed (service life graphs are available). ...
... researchers report that a combination of trastuzumab and neratinib ... receptor (ErbB2) appears active in women with HER2-positive metastatic ... therapies. More than one-quarter of the women in ... the combination therapy. , "I think this is ...
... could be targets for treatments, researchers say , , THURSDAY, May ... in the parts of their brains that monitor behaviors and ... vulnerable to addiction to the drug, a new research shows. ... in these regions of the brain when cocaine users were ...
Cached Medicine News:Health News:Purolator USA Offers Canadian Customs Expertise for Medical Device Exports 2Health News:AGA Institute presents cutting-edge research during DDW 2Health News:AGA Institute presents cutting-edge research during DDW 3Health News:AGA Institute presents cutting-edge research during DDW 4Health News:Draeger Announces New Multi-Gas Plus Cartridge 2Health News:Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer 2Health News:Brain Scans Show Differences in Cocaine Addicts 2
... Mumps IgG Enzyme- linked Immunosorbent Assay (ELISA) ... determination of IgG antibody to Mumps virus ... be used for the determination of immune ... be used to demonstrate seroconversion or a ...
The DSL-05-10-MUG Mumps IgG Enzyme-Linked Immunosorbent Assay (ELISA) kit provides materials for the determination of IgG-class antibodies to Mumps Virus in human serum. This assay is intended for in...
With BareWire technology, the wire crosses the lesion first, independent of the filter and delivery catheter. All other actions, including filter placement and retrieval, balloon dilatations, and ste...
... Ultra Laboratory has been uniquely designed ... single facility to integrated networks spanning ... to management reporting and accounts receivable, ... precise laboratory management. All system modules ...
Medicine Products: