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ALIMTA Helped Keep Most Common Form of Lung Cancer at Bay In Elderly Patients
Date:9/26/2011

sup>a clinical trial investigator for the PARAMOUNT study and physician with S. Giuseppe Moscati Hospital in Avellino, Italy. "In fact, some patients over the age of 70 may simply be offered supportive care alone. These results show that an ALIMTA maintenance regimen could provide benefit to certain elderly patients."

The study included patients with advanced nonsquamous NSCLC who received ALIMTA (500 mg/m2 on day one of a 21-day cycle) in combination with cisplatin (75 mg/m2) induction therapy. Patients whose disease had not progressed during the ALIMTA plus cisplatin induction and had a performance status of 0-1 were randomized to receive ALIMTA maintenance (500 mg/m2 on day one of a 21-day cycle) plus best supportive care or placebo plus best supportive care until disease progression.

Overall, the most serious (laboratory grade 3/4) drug-related adverse events were higher for elderly patients treated with ALIMTA continuation maintenance compared with patients less than 70 years of age (21% vs. 7%). These adverse events were primarily hematological (anemia and neutropenia). Elderly patients in the study tended to have a poorer performance status than younger patients (PS 0: 20% vs. 34%, respectively; PS 1: 79% vs. 66%, respectively), and the older group received more cycles of ALIMTA therapy (5.5 vs. 4.8 in the younger group).

Overall results of PARAMOUNT, which met its primary endpoint of progression-free survival, were presented in June 2011 at the American Society of Clinical Oncology (ASCO) Annual Meeting(1).

Notes to Editor

About Non-Small Cell Lung Cancer (NSCLC)

Globally, lung cancer is the most common form of cancer and the biggest killer, causing 1.3 million cancer deaths annually(2).  About 85 – 90 percent of all lung cancers are NSCLC(3).  The liver, bones and brain are potential targets if the cancerous cells enter the bloodstream.

NSCLC comprises a group of histolo
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SOURCE Eli Lilly and Company
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