Navigation Links
AGI Dermatics Clinical Data Indicate Bicyclic Monoterpene Diols Suppress MMP1 and Stimulate Collagen Through TNF-a Signaling
Date:2/11/2008

Clinical Data Presented at the 66th Annual Meeting of the American Academy

of Dermatology

FREEPORT, N.Y., Feb. 11 /PRNewswire/ -- AGI Dermatics clinical research indicates that the ability of bicyclic monoterpene diols (BMTds) to reduce collagenese MMP-1 secretion and increase collagen production is dependent on the TNF-a signaling in the fibroblasts. The data was presented at the Poster Session at the 66th Annual Meeting of the American Academy of Dermatology in San Antonio.

"Our prior research showed that BMTds increase collagen gene expression and protein production while decreasing MMP-1 secretion," said Daniel Yarosh, PhD, President, AGI Dermatics. "This study gives us insight into the cellular communication that allows BMTds to work so effectively and efficiently in treating photodamaged skin."

BMTds, a class of compounds known to increase nitric oxide levels, were recently reported to play a major role in collagen synthesis. AGI scientists questioned whether the transmission of BMTd factors were influenced by the role of Interleukin-6 (IL-6) and TNF-A in regulating collagen 1 and MMP-1 secretions.

In earlier studies of BMTds, AGI scientists observed a linear increase in BMTd concentrations and secretion of interleukin-6 (IL-6), a multi-functional cytokine that mediates a wide variety of functions in cells, promotes cell proliferation and regulates gene expression. By blocking the IL-6 signaling with a neutralizing IL-6 antibody, studies showed a concomitant increase in MMP-1 and a reduction in collagen 1. The effect of the neutralizing antibody, however, was gradually overcome by increasing BMTd concentrations, indicating that IL-6 is not involved in the transmission of the BMTd effect. Results indicated a linear decrease in MMP-1 secretion and an increase in collagen production, two key components in treatment of photoaged skin.

Similarly, blocking TNF-a signaling in the fibroblasts with
'/>"/>

SOURCE AGI Dermatics
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
4. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
7. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
10. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
11. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... June 18, 2013 Remedy Informatics, a ... and life sciences research, today announced it has ... IT Schedule 70 supply contract (GS-35F-367AA, effective May ... innovative IT solutions to government agencies at federal, ... contract, Remedy has placed its products and services ...
(Date:6/18/2013)... INDIANAPOLIS , June 18, 2013   ... partnership with Aegis Health Group to ... Aegis workforce wellness programs administered by health systems ... system, manufactured by PTS and distributed through ... for total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, ...
(Date:6/17/2013)... Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... a preliminary prospectus supplement to its effective shelf registration statement ... with securities regulatory authorities in each of the provinces of ... offering of its common shares to raise gross proceeds of ... also grant to the underwriters of the Offering an option, ...
Breaking Medicine Technology:Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 2Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 3Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 4Polymer Technology Systems, Inc. to Provide Point-of-Care Lipid Testing to Aegis Health Group's Hospital Clients 2Polymer Technology Systems, Inc. to Provide Point-of-Care Lipid Testing to Aegis Health Group's Hospital Clients 3Valeant Pharmaceuticals Announces Public Offering Of Common Shares 2Valeant Pharmaceuticals Announces Public Offering Of Common Shares 3Valeant Pharmaceuticals Announces Public Offering Of Common Shares 4
... For More Women to ... Participate in Clinical Trials, ORLANDO, ... women remain a significant minority in,cardiovascular randomized controlled trials funded ... Author, Esther S.H. Kim, M.D., M.P.H., Senior Author Venu Menon,M.D., ...
... N.J., Nov. 5 CANTEL MEDICAL,CORP. (NYSE: ... from schools for its hand sanitization and surface ... MRSA,(Methicillin-resistant Staphylococcus aureus) skin infections. According to ... "We are,in contact with numerous school officials helping ...
Cached Medicine Technology:Enrollment of Women in Cardiovascular Trials Fails to Meet Current Federal Mandates 2Cantel Medical Corp.'s Crosstex Subsidiary Addresses School MRSA Concerns With SaniTyze(TM) Brand Hand Sanitizer and Sanitex(R) Surface Disinfecting Line of Products 2Cantel Medical Corp.'s Crosstex Subsidiary Addresses School MRSA Concerns With SaniTyze(TM) Brand Hand Sanitizer and Sanitex(R) Surface Disinfecting Line of Products 3
(Date:6/18/2013)... 2013 Two months ago, Suyima Torres, 28, ... for a second session of a silicone treatment for gluteus ... treatment was allegedly performed by a mystery Venezuelan doctor in ... According to Dr. Bernabe Vazquez of Bayshore Cosmetic Surgery ... from doctor’s who are not board certified is more common ...
(Date:6/18/2013)... Calif. (PRWEB) June 18, 2013 David ... professor of Family Medicine for the College of Osteopathic ... Health Sciences has been elected president of the ... Edmund G. Brown Jr. appointed Connett, a 1984 alumnus ... OMBC members recently elected Connett to the position during ...
(Date:6/18/2013)... to keep their scheduled medical appointments and their ... listens, explains things clearly and knows them as a ... suggests. , "If people feel their doctor really knows ... has their best interests at heart and may be ... Tabor E. Flickinger, M.D., M.P.H., a fellow in the ...
(Date:6/18/2013)... 2013)-- An international team of investigators co-led by Weill ... evidence-based surgery and device research, similar to the kind ... , "Currently, there is no dynamic research framework to ... benefits to patients or may even be harmful," says ... College. , In the June 18 issue of ...
(Date:6/18/2013)... Two weeks ago, eyes across America were glued to ... reported by CNN on June 6 in an article ... building scheduled to be demolished ended up burying a group ... persons succumbed to their injuries. It was a sad ... should serve as a reminder that the safety of Pennsylvania ...
Breaking Medicine News(10 mins):Health News:Dr. Bernabe Vazquez Speaks on Miami Woman’s Deadly Silicone Butt Injection 2Health News:Dr. Bernabe Vazquez Speaks on Miami Woman’s Deadly Silicone Butt Injection 3Health News:Respect may be the key to stopping patient 'no shows' 2Health News:Tackling a framework for surgical innovation 2Health News:Tackling a framework for surgical innovation 3Health News:Ensuring The Safety of Pennsylvania Worksites 2Health News:Ensuring The Safety of Pennsylvania Worksites 3
... study involving 38 populations across 21 countries, reserachers have found ... ,"Blood pressure did not go down in all ... them," said Prof Tunstall-Pedoe, who led the World Health Organization ... was not great, but it did appear to have a ...
... has a connection with obesity risks as they grow up, more so, ... ,A team of researchers led by Sarah E. Anderson, M.S., from Tufts ... women and 417 men - who underwent assessment four times between 1983 ... 18 during the beginning of the study, and were in the age ...
... that India is crowned as the diabetic capital. Hence he ... for prevention and control of cardiovascular disease, //stroke and diabetes. ... ,He submitted a draft of the programme to the ... it workable. ,The programme’s main aim is ...
... Calcium supplementation during pregnancy can reduce the incidence ... a study published by American Journal of Obstetrics ... characterized by elevated blood pressure and proteinuria (high ... the feet, hands and legs is usually seen. ...
... known for a long time that smoking is associated with ... and emphysema. A new study has highlighted that smoker’s children// ... cause pneumonia, sinusitis and meningitis. ,Nothing, not even ... to help people quit smoking. Let us hope that this ...
... pertaining to dental health a common concern is fluoride ... teeth.//, ,This is a revelation of several studies ... Research's annual meeting from March 8, 2006, in Orlando, ... mentioned. ,An Iowa Fluoride Study which followed ...
Cached Medicine News:
For the quantitative determination of Creatine Kinase in serum....
For the quantitative determination of creatine kinase-MB in serum. Kinetic Reaction measured at 340 nm. Linearity: 700 IU/L at 37C....
Intended for the quantitative determination of magnesium in serum or plasma. Reaction: Endpoint. Wavelength: 520 nm. Linearity: 6.0 mg/dL (2.5 mmol/L)....
For the quantitative determination of total glucose in human serum....
Medicine Products: