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AFFiRiS Begins Development of a Parkinson's Vaccine
Date:12/11/2008

et for treating the cause - not just the symptoms - of Parkinson's. However, it is important to bear in mind that alpha-syn is a human protein belonging to a family of proteins with very similar structures like e.g. beta-syn, an essential neuroprotective factor. Therefore, treatment to reduce alpha-syn must not lead to the reduction of related proteins, such as beta-syn. Our AFFITOME technology enables us to develop vaccines that induce antibody specifically targeting alpha-syn only."

Frank Mattner, Chief Scientific Officer at AFFiRiS, adds: "The great potential offered by our AFFITOME technology has been confirmed by external experts, who appraised our development of a Parkinson's vaccine for the Austrian Research Promotion Agency (FFG). Their assessment prompted the FFG to provide considerable financial support for this project."

The AFFITOME technology from AFFiRiS provides a means of targeting very specific structures of human rogue proteins with patented product candidates. AFFiRiS has already succeeded in developing two vaccines and a hemodialysis program for the treatment of Alzheimer's. These therapies only target specific structures found on harmful fragments of beta-amyloid, which is said to be responsible for Alzheimer's. Both Alzheimer's vaccines are currently being trialled on Alzheimer patients. In October, a licence option agreement worth up to EUR 430 million was concluded with GlaxoSmithKline Biologicals for their further clinical development market launch and sales.

About AFFiRiS GmbH (as at December 2008):

AFFiRiS GmbH develops peptide-based vaccines for the treatment of Alzheimer's disease, atherosclerosis and other serious diseases. The company has established its AFFITOME platform technology. It employs 35 highly qualified members of staff on 1,800sqm of rented laboratory facilities at the Campus Vienna Biocenter (http://www
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SOURCE AFFiRiS GmbH
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