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ADVISE Study Results Demonstrate the Instant Wave-Free Ratio™, a Vasodilator-Free Measure of Stenosis Severity, is Comparable to FFR
Date:11/14/2011

SAN DIEGO, Nov. 14, 2011 /PRNewswire/ -- Volcano Corporation (NASDAQ: VOLC), a leading developer and manufacturer of precision guidance therapy tools designed to enhance the treatment of coronary and peripheral vascular disease, and Imperial College London jointly announced the results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study during a Late Breaking Clinical Trial session at the Transcatheter Therapeutics Conference (TCT 2011) in San Francisco. The results have also been accepted for publication in the Journal of the American College of Cardiology.

ADVISE assessed the ability of an investigational product called instant wave-Free Ratio™ (iFR™), to provide a measurement of the severity of a coronary stenosis that is similar  to fractional flow reserve (FFR), the gold standard for assessing ischemia, without the need for pharmacologic vasodilation. iFR was developed by physician-scientists at Imperial College London in partnership with Volcano Corporation.

"FFR is a widely accepted and valuable tool that provides physicians with a clear measurement of the severity of a coronary lesion and helps guide treatment decisions, including whether or not to place a stent to treat stable angina," said ADVISE principal investigator Dr. Justin Davies, an interventional cardiologist at National Heart and Lung Institute at Imperial College London. "However, there are barriers to widespread use of FFR, including the need to inject a vasodilator like adenosine to simulate heart function in an exercise state. The use of adenosine by physicians and staff can increase time, cost and complexity of the procedure, not to mention produce some level of patient discomfort. This new approach provides a pharmaceutical-free assessment of the functional severity of a discrete lesion that correlates very closely with FFR." 

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SOURCE Volcano Corporation
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