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ADVENTRX Reviews Data Supporting Development Of ANX-188 In New Indications
Date:2/26/2013

SAN DIEGO, Feb. 26, 2013 /PRNewswire/ -- ADVENTRX Pharmaceuticals, Inc. (NYSE MKT: ANX) today reviewed the platform of data and know-how that supports development of ANX-188 in multiple indications, including those outside of sickle cell disease.  This platform has been derived from over 100 pharmacology studies, more than 15 clinical studies in multiple indications in which over 2,500 subjects have been exposed to both purified and non-purified poloxamer 188, and over two decades of experience manufacturing and purifying poloxamers. 

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Brian M. Culley , Chief Executive Officer, said:  "Since acquiring SynthRx, we have come to appreciate the extent of the data supporting the development of ANX-188 not just in sickle cell disease, but in any indication where improving microcirculatory insufficiency is central to improving clinical outcomes.  The breadth and depth of these data can be characterized as a 'platform,' which we refer to as the Molecular Adhesion and Sealant Technology, or MAST, platform.  We plan to leverage the knowledge and know-how that is the MAST platform to advance ANX-188 in multiple indications, and will announce development plans outside of sickle cell disease later this quarter." 

R. Martin Emanuele , Ph.D, Senior Vice President, Development, said: "In addition to initiating EPIC, our pivotal phase 3 study in sickle cell disease, we have analyzed the impressive body of data that supports development of ANX-188 in a broader range of diseases and conditions.  ANX-188 adheres specifically to hydrophobic surfaces characteristic of damaged cells in the circulation, effectively 'sealing' the damaged area and, as a result, minimizing or preventing other hydrophobic
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SOURCE ADVENTRX Pharmaceuticals, Inc.
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