ADVENTRX Presents CoFactor Data at the 2008 Annual Meeting of the American Society of Clinical Oncol...(te responses and partialresponses. Accor...),Health

Date:6/3/2008

te responses and partial responses. According to RECIST criteria, a complete response (CR) indicates the disappearance of all target lesions and a partial response (PR) indicates a 30% decrease in the sum of the longest diameter of target lesions. A total of 32 patients were enrolled in this study and 31 patients received at least one dose of drug. A treatment cycle consisted of 60 mg/m2 of CoFactor plus 500 mg/m2 of 5-FU, weekly i.v. (intra-venous) for a period of 6 weeks, repeated every 8 weeks. CoFactor was administered at a dose of 60 mg/m2 as an i.v. bolus over 2-3 minutes. Administration of CoFactor was followed 20 minutes later by 500 mg/m2 of 5-FU as an i.v. bolus over 2-3 minutes.

About ANX-510, or CoFactor

CoFactor is a folate-based biomodulator designed to replace leucovorin as the preferred method to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent 5-FU (5-fluorouracil). Compared to leucovorin, CoFactor creates more stable binding between the active form of 5-FU and the target enzyme, thymidylate synthase. CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, potentially allowing 5-FU to work more effectively.

About ADVENTRX Pharmaceuticals

ADVENTRX Pharmaceuticals is a biopharmaceutical company focused on in-licensing, developing and commercializing proprietary product candidates primarily for the treatment of cancer and infectious disease. The Company seeks to improve the performance and commercial potential of existing treatments by addressing problems associated with these treatment regimens. More information can be found on ADVENTRX's web site at http://www.adventrx.com.

Forward Looking Statements

ADVENTRX cautions you that statements included in this press release that are not a description of historical facts are forward-looking statements that involve risks
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SOURCE ADVENTRX Pharmaceuticals, Inc. Copyright©2008 PR Newswire. All rights reserved

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