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ADMIRE-HF Clinical Trial Published in the Journal of the American College of Cardiology
Date:5/17/2010

ts at the highest risk for cardiac events and cardiac death. The two-year cardiac event rate for patients with BNP above the median of 140 ng/l was 42%, but among patients with H/M greater than or equal to 1.60, the rate was 20.5%. Whereas there were no cardiac deaths among the 57 patients with BNP >140 ng/l and H/M greater than or equal to 1.60, there were 42 cardiac deaths among the 406 patients (10.3%) with above-median BNP and H/M <1.60.(1)

The subanalyses also demonstrated a modest but statistically significant positive correlation between LVEF and H/M. The two-year cardiac event rate for individuals with LVEF <30% and H/M greater than or equal to 1.60 was less than half that of all patients with LVEF <30% (17.6% vs. 40.3%, respectively). There were two cardiac deaths among the 81 patients (2.5%) with LVEF <30% and H/M greater than or equal to 1.60, as compared with 39 cardiac deaths among the 409 (9.5%) patients with LVEF <30% and H/M <1.60. There were no cardiac deaths among the 120 patients with LVEF greater than or equal to 30% and H/M greater than or equal to 1.60.(1)

About Heart Failure

According to the American Heart Association, 5.7 million Americans suffer from heart failure. Cardiovascular disease in all its forms claims about as many lives each year as cancer, chronic lower respiratory diseases, accidents, and diabetes combined.  Patients who have previously suffered from heart failure have a sudden death rate that is six to nine times greater than the general population.(1)

About AdreView

AdreView™ (Iobenguane I 123 Injection) is a molecular imaging agent.  GE Healthcare began developing AdreView in 2004, and the agent was granted orphan-drug status by the Food and Drug Administration (FDA) in December 2006. In <
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