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ADMIRE-HF Clinical Trial Published in the Journal of the American College of Cardiology
Date:5/17/2010

% (mean 27.1%; median 29%) underwent early (15-minute) and late (four-hour) planar and single-photon emission computed tomography (SPECT) myocardial imaging.  Patients were then observed every six to seven weeks over the course of two years to monitor for occurrence of cardiac events.   The composite endpoint was the time to first occurrence of NYHA heart failure class progression, a potentially life-threatening arrhythmic event, or cardiac death, as determined by an independent adjudication panel.(1)

The researchers used the heart/mediastinum ratio (H/M) to assess the functionality of the sympathetic nerves; H/M is a ratio of the nerve function in the heart compared to that of a reference background region in the mediastinum (the mass of tissues and organs between the two pleural sacs, which separate the heart from the lungs). The study was designed to demonstrate that if the cardiac nerves are damaged or reduced in number, as reflected by reduced 123I-mIBG uptake in the heart, the patient is at increased risk for heart failure progression, arrhythmic events, and cardiac death.(1)

The primary analysis employed a Cox proportional hazards model to compare outcomes in subjects with H/M of <1.60 and greater than or equal to 1.60 on late planar imaging.  A multivariable Cox proportional hazards analysis incorporated imaging and clinical variables into a prediction model for adverse cardiac events.(1)

"Using imaging tests are consistent with current trends toward gaining improved and earlier understanding of heart disease at a molecular level and may enable preventive management strategies," said Arnold F. Jacobson, MD, PhD, Head, Cardiac Center of Excellence, GE Healthcare. "This testing method is not new, however ADMIRE-HF is the first large-scale multicenter prospective validation of the potential prognostic power an
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SOURCE GE Healthcare
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