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ADMIRE-HF Clinical Trial Published in the Journal of the American College of Cardiology
Date:5/17/2010

PRINCETON, N.J., May 17 /PRNewswire-FirstCall/ -- The ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) trial, the results of which were published in the May 18th, 2010 issue of the Journal of the American College of Cardiology, is a prospective study evaluating cardiac sympathetic nerve imaging using Iobenguane I 123 Injection (AdreView™) for identifying symptomatic heart failure patients most likely to experience cardiac events.

According to the study, the drug imaging results produced a model with four independent variables contributing to the prediction of the primary outcome events.

"Increased cardiac sympathetic activity is a prominent feature of heart failure and is associated with progressive deterioration and remodeling of the myocardium, inexorable decline in left ventricular function, and worsening symptoms," said Professor Roxy Senior, MD, Director of Cardiac Research Northwick Park Hospital, an author of the study.  "Our results suggest that in appropriately selected patients with heart failure, the 123I-mIBG imaging procedure can alert clinicians to the potential need for considering additional treatments."  

About the ADMIRE-HF Trial

ADMIRE-HF consisted of two identical open-label phase III clinical studies evaluating the cardiac sympathetic nerves at the cellular level.  The studies were conducted in 96 centers in North America and Europe.  Nine hundred sixty-four patients with New York Heart Association (NYHA) Class II (83%) and III (17%) heart failure (66% ischemic, 34% non-ischemic) and left ventricular ejection fraction (LVEF) less than or equal to 35
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SOURCE GE Healthcare
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