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ACTEMRA(R) (tocilizumab) Significantly Reduces Rheumatoid Arthritis Signs and Symptoms Regardless of Previous Therapy in Two New Global Studies
Date:6/13/2008

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(1) ACR20, ACR50, ACR70 represent the percentage of reduction (20%, 50%,

70%) in certain RA symptoms and measures the number of tender and

swollen joints, pain, patient's and physician's global assessments and

certain laboratory markers.

(2) The Disease Activity Score (DAS)28 is a combined index that measures

disease activity in patients with RA. It combines information from 28

tender and swollen joints (range0-28), erythrocyte sedimentation rate,

and a general health assessment on a visual analog scale. The level of

disease activity is interpreted as low (DAS28 less than or equal to

3.2), moderate (3.2

(DAS28>5.1). DAS28<2.6 corresponds to being in remission according to

the criteria of the American College of Rheumatology.

(3) The EULAR response criteria is based on the individual amount of

change in DAS and the DAS value (low, moderate, high disease activity)

reached to classify patients as good, moderate and non-responders
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Related medicine technology :

1. Roche Submits Application for FDA Approval of ACTEMRA(R) for the Treatment of Rheumatoid Arthritis
2. New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients
3. Two Pivotal Phase III Studies for Roches ACTEMRA(TM) (tocilizumab) Demonstrate Significant Improvement in Rheumatoid Arthritis Symptoms
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