Navigation Links
ACTEMRA(R) (tocilizumab) Significantly Reduces Rheumatoid Arthritis Signs and Symptoms Regardless of Previous Therapy in Two New Global Studies
Date:6/13/2008

ate. Levels of C-reactive protein (CRP), a marker of inflammation and hemoglobin levels, showed significant and rapid improvement as early as two weeks in ACTEMRA (8 mg/kg) patients in the AMBITION trial, compared with patients treated with methotrexate alone.

"We are extremely pleased with these results which help us work toward establishing ACTEMRA as a new first-line biologic treatment, which blocks a different inflammatory target than current therapies. We are encouraged that we will soon be able to offer this new treatment option and meaningful benefit to those who need it the most -- the RA patients," said Lars Birgerson, M.D., Ph.D., Vice President, Global Head Medical Affairs, Roche.

About ACTEMRA (tocilizumab)

ACTEMRA is the first humanized interleukin-6 (IL-6) receptor-inhibiting monoclonal antibody. Studies suggest that reducing the activity of IL-6, one of several key cytokines involved in the inflammatory process, may reduce inflammation of the joints and relieve certain systemic effects of RA. The extensive clinical development program conducted by Roche includes five clinical studies and has enrolled more than 4,000 patients in 41 countries, including the United States. Five Phase III studies are completed and have reported meeting their primary endpoints. The LITHE trial evaluating ACTEMRA in RA is an ongoing two-year study and is expected to report complete data evaluating the effects of ACTEMRA on the inhibition of structural joint damage in 2009. ACTEMRA is awaiting approval in the United States and Europe.

ACTEMRA is part of a co-development agreement with Chugai, a Japanese company. In June 2005, ACTEMRA was launched by Chugai in Japan as a therapy for Castleman's disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan.

The serious adverse events reported in ACTEMRA clinical trials were se
'/>"/>

SOURCE Roche
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Roche Submits Application for FDA Approval of ACTEMRA(R) for the Treatment of Rheumatoid Arthritis
2. New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients
3. Two Pivotal Phase III Studies for Roches ACTEMRA(TM) (tocilizumab) Demonstrate Significant Improvement in Rheumatoid Arthritis Symptoms
4. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
5. DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux
6. Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS)
7. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
8. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
9. New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes
10. Promising Phase 3 Trial Results Show Novel Biologic Therapy Ustekinumab (CNTO 1275) Significantly Improved Psoriasis
11. INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Aug. 27, 2014 An experimental drug designed to ... viable first treatment for anemia of inflammation, according to results ... published online today in Blood , the ...   Anemia is a condition that occurs when ... function properly. When an individual has anemia, the body does ...
(Date:8/27/2014)... 27, 2014 Reportlinker.com announces ... is available in its catalogue: ... and Approval of Imported Medical Device ... Edition) http://www.reportlinker.com/p02342770/-Latest-Chinese-Guidebook-for-Application-and-Approval-of-Imported-Medical-Device-Registration-From-Regulations-to-Practices--2014-Edition ... Chinese regulations on medical devices are ...
(Date:8/27/2014)...  Columbia Laboratories, Inc. (Nasdaq: CBRX ) ... clinical trial manufacturing, and advanced analytical and consulting services ... participate at the upcoming Rodman & Renshaw 16 th ... New York . The Company will ... 2014 at the New York Palace Hotel. ...
Breaking Medicine Technology:Drug Represents First Potential Treatment for Common Anemia 2Drug Represents First Potential Treatment for Common Anemia 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 2Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 4Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 5Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 6Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 9Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 10
... presentation on strategic collaboration opportunities with SRI,s ... a nonprofit pharmaceutical organization and have the ... development capabilities – from "Idea to IND"®. ... preclinical phases of basic research, drug discovery, ...
... 15, 2010 A combination of two devices ... arrest patients each year if implemented nationwide, suggests ... American Heart Association Resuscitation Science Symposium. A significantly ... arrest survived after receiving active compression decompression cardiopulmonary ...
Cached Medicine Technology:SRI International Executive Walter Moos to Discuss Collaborative Pharmaceutical Opportunities with a Nonprofit Organization at BIO-Europe 2010 2SRI International Executive Walter Moos to Discuss Collaborative Pharmaceutical Opportunities with a Nonprofit Organization at BIO-Europe 2010 3NIH-Funded Study Is First to Demonstrate Increased Long-Term Survival With Favorable Neurologic Function Among Patients Receiving CPR Using ACSI ResQPump™ and ResQPOD® CPR Devices 2NIH-Funded Study Is First to Demonstrate Increased Long-Term Survival With Favorable Neurologic Function Among Patients Receiving CPR Using ACSI ResQPump™ and ResQPOD® CPR Devices 3
(Date:8/27/2014)... 27, 2014 The extensive polling ... by healthcare research group Black Book Rankings uncovers ... adequately staffed, supplied or built to care for ... initiated this annual survey to gain stakeholder insight ... control, epidemiology and emergency preparedness systems,” said Doug ...
(Date:8/27/2014)... WEDNESDAY, Aug. 27, 2014 (HealthDay News) -- Pouring half a glass ... much, according to a new study. Researchers asked 74 college ... settings and from bottles that had varying amounts of wine in ... normal. Those who had a "rule of thumb" about how ... glass or two fingers from the top -- poured less wine ...
(Date:8/27/2014)... 27, 2014 Connor Sports has ... World Cup in Spain at the Barcelona, Bilbao, Gran ... FIBA Equipment & Venue Centre Partner since 1994 and Official ... six courts will bear the Connor Sports logo and tagline ... globe on the ESPN broadcasts of the FIBA World Cup. ...
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 Picture, if ... not Holmes and Watson but more of a Mr. Inside, ... Davis, in terms of personalities and world view. This Mr. ... University of Texas at Austin, and Mr. Outside was an ... family physician, his new girlfriend, and a gaggle of teenagers ...
(Date:8/27/2014)... NC. SonaCare Medical, LLC, the global ... sales of 15 HIFU devices over the past twelve ... for the company’s ablation technology. , “It is ... achieved over the past year, especially since we are ... our most active sales period,” says Mike Klein, CEO ...
Breaking Medicine News(10 mins):Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 2Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 3Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 4Health News:'Half a Glass' Rule May Curb Overdrinking 2Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 2Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 3Health News:UW Rankin Self-Publishes Debut Novel, Sublimity: Perchance to Dream, A Speculative Science Mystery 2Health News:SonaCare Medical Announces Twelve Months Sales Results of Fifteen HIFU Devices 2
... to treat childhood cholera. ,Researchers in Bangladesh have ... effectively with a single dose // of the antibiotic ... The Lancet., ,Cholera is a major global health ... In the resource-limited countries where cholera occurs, any reduction ...
... issue of JAMA says that heart patients who are ... of medications. ,Heart failure affects more than 5 ... States and is associated with a high death rate, ... to reduce the risk of illness and death from ...
... Professor Alice Sigurdson and Colleagues has reported the dosage ... which increases the risk of thyroid cancer. ... were treated for thyroid cancer during their childhood. The ... risk of developing thyroid cancer and there seems to ...
... elevated to the level of health friends. In the same ... to have benefits for coronary heart disease. ,New research ... effect on heart disease and stroke. A research team in ... that drinking a cup of cocoa can prevent potentially fatal ...
... be less at risk from developing the dreaded disease ... the recent issue of Archives of Neurology. ,In ... the course of a MS-like disease in animals, suggesting ... the postpartum period afterward, both states associated with profound ...
... Risk of bone fracture in postmenopausal women might be reduced ... in the September issue of the journal Archives of Internal ... rate of three to five percent per year for about ... high risk for bone fracture, according to background information in ...
Cached Medicine News:Health News:Heart Patients More At Risk Get Fewer Medicines 2Health News:Risk of Thyroid cancer is increased after Childhood Irradiation of Neck region 2Health News:Cocoa: Doesn’t Taste Like Red Wine But Has Benefits Like It 2Health News:Consumption of Soy May Reduce Risk of Fracture in Postmenopausal Women 2
... Uniflex® Nailing System was to develop a ... the widest possible variety of femoral fractures. ... the system takes full advantage of our ... healing combined with modern materials and biomechanical ...
... Quad 4™ Intramedullary Nailing System was to ... used for the widest possible variety of ... were to minimize the number of implants ... system that could address antegrade or retrograde ...
... latest in the Magnes line of biomagnetometer systems, ... full cortical coverage, provides the highest detector density ... of a wide range of neuronal activity. The ... detector configurations and can be equipped with radial ...
... easy voice access to information on the ... easy and intuitive, enabling you to interact ... With the VoiceBox Voice Information Retrieval Software, ... of subjects and topics and receive up-to-date ...
Medicine Products: