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ACD Announces Clinical Study Results Using its RNAscope™ Technology
Date:2/28/2011

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"The incidences of HPV-associated head and neck cancers are increasing rapidly in the US and worldwide, and the clinical community has been looking for a robust, definitive HPV test," said Dr. Xiao-Jun Ma, Chief Scientific Officer of ACD, "E6/E7 mRNA has long been recognized as the best biomarker for HPV-associated cancers, but its detection by RT-PCR has been limited to research use only due to the complexity of dealing with formalin-fixed paraffin-embedded (FFPE) tissue specimens. This study demonstrated that RNAscope™ is well suited for bringing E6/E7 mRNA testing into the clinic."

"ACD aims to empower pathologists in molecular diagnostics by making RNAscope™ seamlessly compatible with routine FFPE tissue specimen and with existing workflow in pathology labs," commented Dr. Yuling Luo, President & CEO of ACD. Dr. Luo continued, "The outcome of this study is the first concrete evidence that we have made significant progress toward this goal."

About head and neck cancer:

Head and neck cancer comprises cancers arising in the head and neck area, e.g., mouth, nose, throat, etc. It has an estimated incidence of approximately 50,000 in the US and 400,000 worldwide each year. Traditional risk factors for head and neck cancers are mainly tobacco smoking and alcohol drinking. Recently, a subset of head and neck cancers, especially those from the oropharynx, has been shown to be associated with the sexually transmitted human papillomavirus (HPV). HPV-associated cancers are both biologically and clinically different from those unrelated to HPV: they usually carry wild type p53 and do not overexpress EGFR, present in younger men, and have a more favorable prognosis, probably due to their higher sensitivity to radiation and chemotherapy. Because of these differences, clinical trials are being designed specifically for HPV-associated oropharyngeal tumors and for HPV-unrelated tumors to optimize therapies based on HPV status.

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SOURCE Advanced Cell Diagnostics, Inc.
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