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AACC Annual Meeting Breaking Science Includes New Tests to Detect Life-Threatening Prostate Cancer, New Cystic Fibrosis Tests That Can Be Measured at the Point of Care, and New Ways to Determine the Safety of Drugs Used to Treat Schizophrenia and Bi
Date:7/18/2013

consider what decisions need to be made about managing a health condition. At AACC's 2013 Annual Meeting, Xuan Mu, PhD, Peking Union Medical College, will present test results from cystic fibrosis patients using an exciting new point-of-care method. Microfluidics and color changes within a Band-Aid type of adhesive strip on the skin allow the new device to rapidly, accurately, and quantitatively diagnose cystic fibrosis in a small amount of sweat. The new point-of-care test device conveniently integrates the many separate steps of current sweat chloride tests whose results take several hours to obtain. 

Olanzapine is approved by the U.S. Food and Drug Administration (FDA) for treating schizophrenia and bipolar disorder in adults and children older than 13, and is one of the most widely prescribed of the atypical antipsychotics. On June 18, the FDA issued a drug safety alert on the injectable form of olanzapine. Under investigation are two unexplained deaths of patients who received an intramuscular injection of Zyprexa Relprevv (olanzapine pamoate). The agency said that the patients had very high blood levels of the drug, but that they had received appropriate doses. They died 3–4 days after injection. At this year's AACC Annual Meeting in Houston, AACC member Werner Steimer, MD, Ludwig Maximilian University of Munich, will present the results of research showing that study patients who carried a specific genetic variation in an antipsychotic-metabolizing enzyme developed significantly higher serum concentrations of the drug olanzapine. This is the first study to demonstrate that this polymorphism influences serum levels of olanzapine.

In addition to this breaking science, 2013's plenary sessions feature expert presentations on the role of insulin in obesity, the function of "junk" DNA in human development, and the controversy over
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