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A brief explanation of Dopamine-Beta-hydroxylase (DBH) - SymPath(R) : In Vitro Diagnostic Test to distinguish anxious disorders from depressive disorders
Date:9/30/2010

zophrenia and stress related diseases were respectively studied working with catecholaminergic, serotoninergic and cholinergic pathways related to the motor system (monkeys), to the memory mechanisms (cats), learning disabilities (human beings), anorexia nervosa (human beings), bulimia (developing a model with rats in regards to people waiting for bypass surgery). As the relationship between the brain and the HPAS Axis is a key issue in stress related diseases, various stressful situations such as, cold exposure, immobilization and treadmill in rats, hypoxia in fish, a workload in a swimming pool in humans, food behaviours using cats, rabbits, rats, minks and fishes. Finally, in rats, the effects of spontaneously hypertensive state on DBH enzyme activity were compared to clinical data obtained from a group of post MI people.

DBH, the synthesising enzyme of noradrenaline from dopamine, is a copper and ascorbate dependent. Noradrenaline, a vasoconstrictor, is released within the blood from the SNS with DBH. Its biochemical and kinetic parameters were studied in brain, adrenals and serum (Fortin & Roberge, 1992) and in human beings to figure out how a commercial kit could be useful for different clinical purposes on a daily basis (US Patent (#5879902) and Canadian Patent (# 2204179)). In human beings, several studies were conducted involving different sexes, age, Rhesus factor, blood groups, seasonal variations, diurnal rhythms and endocrine functions..

In summary, noradrenaline, a vasoconstrictor, is released within the blood from the SNS with DBH. A commercial kit named SymPath(R) has been developed to quantitatively standardize the measurement kit of the specific activity of DBH released within the blood from the SNS. In this regards, the clinical data allow to distinguish anxious disorders from depressive disorders - that is a breakthrough in neurosciences.

Contact: Neuro-Biotech Corp. Dr Claude Poulin 41 61 500 05 16

SOURCE Neuro-Biotech Corp.
Copyright©2010 PR Newswire.
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