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A brief explanation of Dopamine-Beta-hydroxylase (DBH) - SymPath(R) : In Vitro Diagnostic Test to distinguish anxious disorders from depressive disorders
Date:9/30/2010

BASEL, Switzerland, Sept. 30 /PRNewswire-FirstCall/ - Neuro-Biotech Corporation (PINKSHEET: MRES)(OTCQB:MRES) in acquiring licenses to commercialize 12 Neuro-biomarkers has first focused on SymPath(R) and is now ready to give you the opportunity to shed some light about this Neuro-biomarker of the Sympathetic Nervous System (SNS). Here is a peak into the research behind the Neuro-blood testing that will be available to all patients through their health system.

It is important to pinpoint that DBH was first described in 1955 and reviewed in 1965 by Kaufman & Friedman. In 1974, Geffen has described DBH as a biomarker of the SNS. At that moment, in the Journal of Neurochemistry, Roberge et al. (1976) have published that an inversed relationship occurs between the brain dopamine and serotonin content on a neuroanatomical basis. As in the brain, the noradrenergic and serotoninergic pathways are closed together at the level of the locus coereleus, the raphei nuclei and the brainstem, respectively (Roberge & Poirier, 1973, 1974) and that, to an increased dopamine content following the administration of L-DOPA in monkeys did not correspond to increased noradrenaline content within several neuroanatomical structures in the brain. Moreover, it was demonstrated that DBH was involved in anxiety and depression (Friedman et al., 1984).

In this respect, working with 15 to 18 different brain structures, the effects observed in the structures related to the motor system were different to those noted within the mesolimbic system - it was the starting point to understand how DBH is working to be the key enzyme in the noradrenaline synthesis.

The kinetic DBH enzyme activity and biochemical parameters were respectively studied in the brain, adrenals and blood of different species such as monkeys, cats, rats, rabbits, fish, mink, sheep and human beings using various stressful situations and several drugs. In this respect, Parkinson Disease, Alzheimer, Schi
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SOURCE Neuro-Biotech Corp.
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