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A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol
Date:8/30/2007

3 mg/kg on two consecutive days immediately prior to the cisplatin administration. Treatment was for six weeks and was continued until dose limiting toxicity or disease progression.

In this trial, as measured using the RECIST criteria, in the cisplatin arm there were six partial responders, nine patients with stabilized disease and six patients who had disease progression; in the paclitaxel arm, there was one complete responder, two partial responders, eleven with stabilized disease and five patients who had disease progression. For more information about RECIST, visit http://www.recist.com. There were few side effects associated with phenoxodiol, but, as with any investigational drug, there is a possibility of unexpected side effects.

Women who are interested in participating in the OVATURE trial, or who simply wish to learn more about this study should visit http://www.OVATUREtrial.com.

(1) Piura B and Meirovitz M. Weekly single-agent carboplatin in heavily pretreated patients with recurrent ovarian, peritoneal and fallopian tube carcinoma. Eur J Gynaecol Oncol. 2005;26(4):386-90.

About Phenoxodiol

Phenoxodiol is believed to help chemotherapy drugs, such as carboplatin, kill chemoresistant cancer cells by removing factors in the cells that block the killing action of chemotherapy.

Phenoxodiol appears to selectively inhibit the pro-survival regulator in cancer cells known as S-1-P (sphingosine-1-phosphate) that is over expressed in cancer. In response to Phenoxodiol, the S-1-P content in cancer cells is decreased rendering those cells more sensitive to chemotherapy. Indeed, in laboratory studies, it has been demonstrated that cancer cells pre-treated with phenoxodiol were killed with lower doses of chemotherapy drugs.

Importantly, phenoxodiol has been shown not to adversely affect normal cells in animal and laboratory t
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SOURCE Marshall Edwards Inc.
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