Navigation Links
A Novel Oral Anticoagulant is Planned to be Developed for Patients with Prosthetic Heart Valves or Chronic Renal Dysfunction
Date:3/8/2013

California San Francisco (UCSF), a world-renowned expert in pharmacokinetics, CYP-dependent drug metabolism and P-gp dependent drug transport.

Unlike many of the novel non-monitored OACs and warfarin, tecarfarin is not metabolized by CYP enzymes or transported by P-gp in addition to not being excreted via the kidney.

"For oral anticoagulation, we believe tecarfarin if approved will be an important clinical tool in addition to warfarin and the novel non-monitored OACs. We are preparing to meet with the FDA and the EMA to propose a clinical trial design and final registration package for tecarfarin in these two regions," said Dr M. (Ken) Kengatharan ,  President & COO of Armetheon and a General Partner at Atheneos Capital. He added, "we expect to submit for marketing authorization in the US and the EU in less than 4 years. With an increasing use of CYP variant genetic testing and the recent uptick in patient self-monitoring perhaps due to reimbursement  by healthcare providers, we strongly believe the time to develop and commercialize tecarfarin is now."

About anti-coagulation therapy in special populations

Oral anticoagulants, are used to slow down or stop the formation of blood clots in the out-patient environment. Currently available anticoagulants include warfarin (Coumadin®) that inhibits vitamin K epoxide (VKOR) and the novel non-monitored OACs that directly either inhibit thrombin or Factor Xa. In patients with prosthetic heart valves, OACs are given to prevent clot formation within these valves. Patients with mechanical heart valves generally remain on warfarin sometimes in combination with aspirin while most patients with bioprosthetic valves are eventually switched to aspirin. However, experts now recommend that the novel non-monitored OACs should not to be used in these patients.

In patients, who have a genetic variant of metabolizing enzymes such as CYP2C9, anticoagul
'/>"/>

SOURCE Armetheon, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
2. Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Market
3. Upcoming Presentations on Global Market Access Issues and Trends in Health Economics and Outcomes Research at ISPOR 2012 by Novel Health Strategies
4. Scripps Doctors Study Novel New Device to Diagnose Irregular Heart Beat
5. Novelos Therapeutics Successfully Completes First Cohort In Phase 1b Solid Tumor Trial With I-131-CLR1404 (HOT) Cancer-Targeted Molecular Radiotherapeutic
6. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
7. New Data Support Role of Prometheus Laboratories Novel Assay in Optimizing IBD Treatment Management
8. Stiefel, a GSK company, enters agreement with Welichem Biotech, Inc. to acquire a novel topical agent for psoriasis and atopic dermatitis
9. Taiho Pharmaceutical Announces Start of Global Phase III Clinical Trial in Metastatic Colorectal Cancer with Novel Antitumor Agent TAS-102
10. OICR funds Fluorinov Pharma Inc. to further develop its novel drug for the treatment of blood cancers
11. CSL Behring Receives FDA Orphan Drug Designation for rIX-FP, a Novel Therapy in Development to Treat Congenital Factor IX Deficiency (Hemophilia B)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... -- MinuteClinic, the largest and fastest growing provider of retail medical clinics ... first walk-in clinics in the Corpus Christi ... and Portland . A third clinic ... The clinics are part of MinuteClinic,s national expansion plan ... Corpus Christi -area openings, there are now more than ...
(Date:10/2/2014)... 2014   Mast Therapeutics, Inc. (NYSE MKT: ... Edwin L. Parsley , D.O. has joined the Company ... Dr. Parsley has been actively engaged with ... February 2014.  He has served as Mast,s interim Chief ... Officer of Aires since April 2011.  Dr. Parsley previously ...
(Date:10/1/2014)... 2014  Abaxis, Inc. (NasdaqGS: ABAX ), ... for the medical, research, and veterinary markets worldwide and ... markets in the United States , ... agreement with Patterson Veterinary Supply. Patterson ... of Abaxis veterinary products throughout the United ...
Breaking Medicine Technology:First MinuteClinic Walk-in Medical Clinics Open in Corpus Christi 2First MinuteClinic Walk-in Medical Clinics Open in Corpus Christi 3Mast Therapeutics Announces Appointment Of Chief Medical Officer 2Mast Therapeutics Announces Appointment Of Chief Medical Officer 3Mast Therapeutics Announces Appointment Of Chief Medical Officer 4Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 2Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 3Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 4
... N.J., Oct. 26, 2011 Pharmaceutical gurus know that the ... is to get together with the field,s leading experts. And ... popular event that takes place just once a year: the ... 7-8 at the Hilton Parsippany Hotel in Parsippany, New Jersey. ...
... the leading innovator in epicardial ablation devices, announced today ... and www.ncontactinc.com . The design of the ... and the market for treating cardiac arrhythmias that affect ... are excellent educational references that highlight how our technology ...
Cached Medicine Technology:Pharmaceutical Industry Leaders to Tackle Groundbreaking Challenges, Opportunities for Pharma & Biotech at Elite Event 2nContact, Inc. Launches New Corporate Websites 2
(Date:10/1/2014)... by the Engineering and Physical Sciences Research Council ... UK,s vital industrial control systems which run, for ... and the rail network. , The research ... or malware infiltrating the systems behind our critical ... Trustworthy Industrial Control Systems (RITICS), based at Imperial ...
(Date:10/1/2014)... Despite a policy focus on expanding access ... vulnerable population continues to have significant dental disease. ... of the American Dental Association , researchers from ... School of Dental Medicine report on the first ... care provided by caregivers to adults with developmental ...
(Date:10/1/2014)... Familylifeinsurancequotes.org has released a new blog post explaining ... , Senior citizens can qualify for affordable term life ... who are over 50 years old. Some term life ... examination. , Term life insurance with a simplified issue ... Having life insurance during retirement is important for covering ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Insuranceragents.info ... find a good life insurance plan for vulnerable family ... for vulnerable family members. Providers in the family should ... will cause financial hardships for the rest of the ... of policies. Families can benefit more from temporary coverage ...
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post explaining ... smokers. , Smoking will always have a negative impact ... best method to find affordable coverage. Insurance brokerage websites ... , Whole life insurance premiums will be fixed ... coverage is permanent, the initial rates are very ...
Breaking Medicine News(10 mins):Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3Health News:Affordable Term Life Insurance - Senior Citizens Can Qualify for Coverage! 2Health News:Life Insurance for Families - Clients Can Compare Affordable Rates Online! 2Health News:Affordable Whole Life Insurance Premiums for Smokers! 2
... ... adherence and effectiveness during NACDS Annual Meeting , ... Palm Beach, FL (Vocus) April 27, 2010 -- In his first remarks ... Drug Stores ( NACDS ), Larry J. Merlo, president of CVS/pharmacy, paid tribute to ...
... Psychopaths are known to be characterized by callousness, diminished ... exact cause of these personality traits is an area ... study, reported in the May 2010 issue of Elsevier,s ... between the mental impairments observed in psychopaths and those ...
... ... Florida to Use Via Oncology Pathways to Ensure the Best Treatment for Each Patient ... ... a subsidiary of the University of Pittsburgh Medical Center (UPMC), announced that Space Coast ...
... , ... chewy, preservative-free snacks that are low-calorie, low in sugar and high in antioxidants. Summer is just ... cookies. Go ahead and kick Summer off with the healthiest berry on earth! , ... New York, NY (PRWEB) April 26, 2010 -- Move ...
... for men with advanced disease, studies found, , TUESDAY, ... week of a therapeutic prostate cancer vaccine by the ... against the disease and cancer in general, experts say. ... in men with advanced prostate cancer, and it does ...
... ... 2-1 that they would re-elect President Obama over former Massachusetts Governor Mitt Romney and former ... ... ., the leading conference, training and publishing company for direct-to-consumer (DTC) marketing, today revealed that ...
Cached Medicine News:Health News:New NACDS Chairman Larry Merlo Emphasizes Personal Commitment, Connection to Pharmacy 2Health News:New NACDS Chairman Larry Merlo Emphasizes Personal Commitment, Connection to Pharmacy 3Health News:An underlying cause for psychopathic behavior? 2Health News:Space Coast Cancer Center Selects Via Oncology™ Pathways to Advance Evidence-Based Cancer Care 2Health News:Space Coast Cancer Center Selects Via Oncology™ Pathways to Advance Evidence-Based Cancer Care 3Health News:Space Coast Cancer Center Selects Via Oncology™ Pathways to Advance Evidence-Based Cancer Care 4Health News:Supercharge Summer with Superfood-infused Cookies! 2Health News:Supercharge Summer with Superfood-infused Cookies! 3Health News:Prostate Cancer Vaccine May Get FDA Approval 2Health News:Prostate Cancer Vaccine May Get FDA Approval 3Health News:Top DTC Marketers Choose Obama Over Romney and Palin 2Health News:Top DTC Marketers Choose Obama Over Romney and Palin 3
Foldable Hydrophilic IOL with UV Absorber....
The STAAR ELASTIC LENS®, is a single piece silicone lens to be placed completely in the capsular bag....
... Engineers at Pfizer used wavefront sensing ... Optic Technology. Innovative TECNIS features a patented ... spherical aberration, which compensates for the positive ... result, TECNIS is the first and only ...
... PhacoFlexII SI30NB is foldable silicone ... it's patients. It is used ... SI30NB is indicated for primary ... of aphakia in adults (over ...
Medicine Products: