Navigation Links
A Novel Oral Anticoagulant is Planned to be Developed for Patients with Prosthetic Heart Valves or Chronic Renal Dysfunction
Date:3/8/2013

tic variant of this enzyme.

"Tecarfarin was specifically designed not to be metabolized by any CYP enzymes, which means it may require less monitoring than warfarin. Some monitoring, according to experts, may still be needed to ensure patient compliance. Data from EMBRACE-AC trial showed that tecarfarin is a more effective OAC than warfarin in patients with a CYP2C9 genetic variant taking at least one CYP2C9 inhibitor despite close monitoring," said Dr Peter Milner , Executive Chairman of Armetheon and partner at AshHill Pharmaceutical Investments.  He added, "for approval of tecarfarin, we anticipate only one more pivotal clinical trial will be required which could be a 'real world', open label study involving about 2500 pre-defined patients."

Recent research indicates that patients with chronic renal dysfunction or failure have reduced or variable activity of CYP enzymes such as CYP2C9 and CYP3A4 as well as the transporter permeability glycoprotein (P-gp). This may explain warfarin's suboptimal performance in this patient population. Currently marketed novel non-monitored OACs (in particular, Factor Xa inhibitors) are eliminated via the kidney and most of them are metabolized via CYP3A4 enzymes in addition to interacting with the P-gp. This may explain the significant variability in anticoagulation response to the novel non-monitored OACs in patients with chronic renal dysfunction or failure.

"Genetic and other sources of variability in the drug metabolizing enzymes CYP3A4 and CYP2C9 or transport related proteins such a P-gp could lead to unpredictable variability in plasma levels of drugs that are metabolized/eliminated through these pathways, particularly if they are used with concomitant medications that may be inhibitors of these metabolic/elimination pathways," said Professor Leslie Z. Benet , former Chairman and Professor of Biopharmaceutical Sciences at University of
'/>"/>

SOURCE Armetheon, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
2. Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Market
3. Upcoming Presentations on Global Market Access Issues and Trends in Health Economics and Outcomes Research at ISPOR 2012 by Novel Health Strategies
4. Scripps Doctors Study Novel New Device to Diagnose Irregular Heart Beat
5. Novelos Therapeutics Successfully Completes First Cohort In Phase 1b Solid Tumor Trial With I-131-CLR1404 (HOT) Cancer-Targeted Molecular Radiotherapeutic
6. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
7. New Data Support Role of Prometheus Laboratories Novel Assay in Optimizing IBD Treatment Management
8. Stiefel, a GSK company, enters agreement with Welichem Biotech, Inc. to acquire a novel topical agent for psoriasis and atopic dermatitis
9. Taiho Pharmaceutical Announces Start of Global Phase III Clinical Trial in Metastatic Colorectal Cancer with Novel Antitumor Agent TAS-102
10. OICR funds Fluorinov Pharma Inc. to further develop its novel drug for the treatment of blood cancers
11. CSL Behring Receives FDA Orphan Drug Designation for rIX-FP, a Novel Therapy in Development to Treat Congenital Factor IX Deficiency (Hemophilia B)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 2014 CVS Health (NYSE: CVS ) ... three leading regional health systems to enhance access to high-quality, ... include Baptist Health System in Alabama ; ... in Pennsylvania , Northwest Medical Center, including ... Tennova Healthcare in Tennessee ; and Premier ...
(Date:10/30/2014)... , Oct. 30, 2014  CytRx Corporation ... and development company specializing in oncology, today announced ... its lead drug candidate, aldoxorubicin.  The presentation, titled, ... Approach," will be given by Sant P. ... Oncology Center and principal investigator of the Company,s ...
(Date:10/30/2014)... Oct. 30, 2014 Today, DripDrop, the ... that it was awarded a two-year contract, effective ... company that serves the more than 100,000 members ... Association and Provista.  DripDrop also ... from member hospitals who attended the recent Novation ...
Breaking Medicine Technology:CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 4CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 2CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 3CytRx Announces Oral Presentation at 2014 Chemotherapy Foundation Symposium 4DripDrop Partners With Novation To Help Hospitals Address I.V. Saline Solution Shortages; ORS Product Used For Ebola Outbreak 2DripDrop Partners With Novation To Help Hospitals Address I.V. Saline Solution Shortages; ORS Product Used For Ebola Outbreak 3DripDrop Partners With Novation To Help Hospitals Address I.V. Saline Solution Shortages; ORS Product Used For Ebola Outbreak 4
... Reportlinker.com announces that a new market research ... Vaccines - Western Europe ... market research report package offers an in-depth perspective ... outlook for vaccines in Western European markets. The ...
... 2012 Reportlinker.com announces that a new ... catalogue: Pharmaceuticals: Global ... http://www.reportlinker.com/p0191852/Pharmaceuticals-Global-Industry-Guide.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pharmaceu Pharmaceuticals: Global Industry ... data and analysis covering the Pharmaceuticals industry. ...
Cached Medicine Technology:Vaccines - Western Europe 2Pharmaceuticals: Global Industry Guide 2Pharmaceuticals: Global Industry Guide 3Pharmaceuticals: Global Industry Guide 4Pharmaceuticals: Global Industry Guide 5Pharmaceuticals: Global Industry Guide 6Pharmaceuticals: Global Industry Guide 7Pharmaceuticals: Global Industry Guide 8Pharmaceuticals: Global Industry Guide 9Pharmaceuticals: Global Industry Guide 10Pharmaceuticals: Global Industry Guide 11Pharmaceuticals: Global Industry Guide 12Pharmaceuticals: Global Industry Guide 13Pharmaceuticals: Global Industry Guide 14Pharmaceuticals: Global Industry Guide 15
(Date:10/30/2014)... N.C. (PRWEB) October 30, 2014 Paramount ... health care, is increasing efforts to help people save ... expenses continue to increase for prescription drugs in the ... valuable savings and resources to bridge the relationship between ... One of the biggest challenges people face today with ...
(Date:10/30/2014)... By Dennis Thompson ... -- The Ebola outbreak in Liberia -- one of three ... slowing, World Health Organization officials said Wednesday. Dr. Bruce ... in the number of burials in Liberia and no increase ... the global push to tame the epidemic may be making ...
(Date:10/30/2014)... California (PRWEB) October 30, 2014 Global ... by 2020, according to a new study by Grand ... with surging demand for sugar and fat free products ... augment the demand for prebiotics over the forecast period. ... http://www.grandviewresearch.com/industry-analysis/prebiotics-market , Food & beverage was the largest ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 The annual ... (NAMS) came to a close on Saturday, October 18th, ... the Society’s inception in 1989. NAMS is North America’s ... quality of life of all women during midlife and ... With over 2,000 physicians and thought leaders from fields ...
(Date:10/30/2014)... Scientists who used stem cells to create miniature human ... a new way to learn more about the development ... human pluripotent stem cells -- which can become any ... the functional miniature stomachs, to study infection by ... and stomach cancer. The miniature stomachs offer many ...
Breaking Medicine News(10 mins):Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 2Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 3Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 4Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 5Health News:Highlights from The North American Menopause Society 25th Annual Meeting 2Health News:Highlights from The North American Menopause Society 25th Annual Meeting 3
... of barrier islands published earlier this spring offers the most ... that hug the coasts of the world,s landmasses. The study, ... Orrin Pilkey of Duke University, Durham, N.C., offers new insight ... and how they may fare as the climate changes and ...
... a small, observational study conducted at the University at ... treat type 2 diabetes, also helps type 1 diabetics ... levels. If the findings are confirmed in a ... UB researchers, they could mean the first significant, new ...
... a new study published today in the journal Nature ... genetic code. The findings, though early, are significant because they ... disorders, such as cystic fibrosis, muscular dystrophy and many forms ... of instructions in a gene that tell a cell how ...
... WEDNESDAY, June 15 (HealthDay News) -- A full 80 percent ... of life expectancy, and the gap is getting bigger, according ... areas of the United States is actually decreasing, whereas it,s ... "The gap between the U.S. and the 10 countries ...
... & Africa Osteoporosis Meeting, to be held in Dubai, ... at , http://www.iofbonehealth.org/dubai-2011/programme.html To encourage participation ... USD each for the top five abstracts by investigators ... is June 17, 2011; all accepted abstracts will be ...
... (June 15, 2011) Geisinger Health System vaccinated more ... with a modification of a mandatory program. On ... flu vaccinations. In an article published in July,s ... of the Society for Healthcare Epidemiology of America, Dr. ...
Cached Medicine News:Health News:What will climate change and sea level rise mean for barrier islands? 2Health News:What will climate change and sea level rise mean for barrier islands? 3Health News:What will climate change and sea level rise mean for barrier islands? 4Health News:Study suggests drug significantly improves glycemic control in type 1 diabetics on insulin 2Health News:Changing genetic 'red light' to green holds promise for treating disease 2Health News:Changing genetic 'red light' to green holds promise for treating disease 3Health News:U.S. Found to Be Losing Ground in Life Expectancy 2Health News:U.S. Found to Be Losing Ground in Life Expectancy 3Health News:Program announced for 1st Middle-East & Africa Osteoporosis Meeting 2Health News:Health system achieves high flu vaccination rates by mandating masking 2
... Tests are available in 14 configurations including ... using Microgenics Antibody Technology, the SureStep™ MDMA ... care immunoassay targeted to detect MDMA that ... MDEA but no cross-reactivity to any isomer ...
... The InstaCheck® multi-drug test ... simply and easily. Negative results ... few as 3 minutes; positive ... A simple, one-time urine sample ...
... Screen Tests are available in 14 configurations ... Designed using Microgenics Antibody Technology, the SureStep™ ... of care immunoassay targeted to detect MDMA ... and MDEA but no cross-reactivity to any ...
AccuSign® DOA Series Opiates Test...
Medicine Products: