Navigation Links
5-Year Study Published in Diabetologia Demonstrated Long-Term Safety of Lantus(R) Compared to NPH
Date:7/6/2009

ep progression in the Early Treatment Diabetic Retinopathy Study (ETDRS) retinopathy patient-level severity scale after treatment with either insulin. Masked, centralized grading of seven-field stereoscopic fundus photographs was used.

Main characteristics of the population were the following and well balanced between groups: : mean age 55, 54% males, mean baseline HbA1c 8.4 vs 8.3% (glargine vs NPH) diabetes duration 11 years, and about 70% of the population was already treated with insulin prior to study entry.

Similarly sustained glycaemic control was observed in both the glargine and NPH treatment groups. Despite a slightly greater severity of diabetic retinopathy for the glargine-treated group at baseline, greater than or equal to 3-step progression in ETDRS score from baseline to end-of-study was similar between treatment groups (14.2% [53/374] of glargine-treated patients vs 15.7% [57/363] of NPH-treated patients). Other measures of retinopathy - the development of proliferative diabetic retinopathy and progression to clinically significant macular oedema - occurred to a similar degree in both treatment groups. Rates of symptomatic and clinically important hypoglycaemia were significantly lower in the glargine group: NPH insulin was associated with a significantly greater incidence of severe hypoglycemia than was insulin glargine (11.1% vs 7.6% respectively, p=0.0439) and mean yearly rates of symptomatic hypoglycemia (7.08+/-16.49 vs 5.13+/-12.79, p=0.0017). Body weight gain tended to be greater with NPH insulin compared with insulin glargine treatment, with a baseline to endpoint increase in mean body weight of 3.7 kg for insulin glargine and 4.8 kg for NPH insulin (ITT population; p=0.0505). No other safety issues for either insulin emerged during the 5-year study.

About sanofi-aventis

Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and distributes thera
'/>"/>

SOURCE sanofi-aventis
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. JACC Identifies DEFER with 5-year Outcomes as Landmark Trial
2. Clinical Data Demonstrates 5-Year Efficacy and Safety of Aquamid(R) in Facial Augmentation
3. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
4. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
5. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
6. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
7. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
10. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
11. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... AARP Foundation today announced it has established a relief ... cold weather that has gripped much of the nation. AARP ... so to support these emergency relief efforts AARP and AARP ... mean up to $500,000 in aid. The matching program will ...
(Date:1/15/2014)... 15, 2014 Shire plc (LSE: SHP, NASDAQ: ... Fair Trading (OFT) approval condition to the announced tender offer for ... As a result of the waiver, the transaction is ... the tender offer on January 24, 2014 following the currently scheduled ...
(Date:1/15/2014)... , Jan. 15, 2014  In an unprecedented effort to curb ... in ambulances and other transport vehicles, an advanced and portable UV ... personnel for the first time. In order to ... these deadly pathogens, West Palm Beach Fire ...
Breaking Medicine Technology:AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Superbugs No Longer Ride In Rescue Vehicles 2
(Date:7/9/2014)... Perelman School of Medicine at the University of Pennsylvania ... received an $8 million grant from the National Cancer ... therapy (PDT) in patients with malignant pleural mesothelioma, a ... itself in the lining of the lungs and is ... will fund a clinical trial and additional studies looking ...
(Date:7/9/2014)... the metabolism of stromal support cells and immune cells ... cell types in the development of diseases could ... cancer. That was the conclusion of a review article ... leading journal Nature . , Prof. Peter Carmeliet: ... The metabolism of cancer cells has been examined in ...
(Date:7/9/2014)... Although feelings are personal and subjective, the ... that objectively represents emotions across different senses, situations ... Cornell University neuroscientist Adam Anderson. , "We discovered ... orbitofrontal cortex, an area of the brain associated ... which captures an individual,s subjective feeling," says Anderson, ...
(Date:7/9/2014)... watching World Cup highlights, Brian Williams refreshing old school ... positions on railings. A University of Colorado Cancer Center ... shows that YouTube also allows researchers, journals, and health ... of skin cancer and prevention. , "No matter what ... how we communicate around the world," says Chante Karimkhani, ...
(Date:7/9/2014)... poor printing on prescription labels handed out by ... errors in taking medication, according to new research ... National Institute for the Blind)., The study, published ... found that labels on prescription medications dispensed by ... for legibility. , By simply following recommended guidelines ...
Breaking Medicine News(10 mins):Health News:Penn mesothelioma program receives $8 million NCI grant 2Health News:Wake-up call for more research into cell metabolism 2Health News:Study cracks how the brain processes emotions 2Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
... Journal of the American Medical Association finds that despite ... ever. Doctors' training, or// residency includes shifts that involve ... for Graduate Medical Education (ACGME) say that they must ... of Harvard Medical School, and colleagues said that interns ...
... A study in the September issue of Archives of Pediatrics ... hospitals must be prepared in the event of a conflict// ... noninjured children who need urgent medical care. The report is ... Iraq. ,Military hospitals are likely to encounter injured ...
... Princess Kiko of Japan, who gave birth to a male ... umbilical cord for transplantation to leukemia patients, Masao// Nakabayashi, director ... Akishino and Princess Kiko made the offer after she gave ... register it on her request," Nakabayashi told reporters. Experts say ...
... Limited, the market leader in oral care, in association ... September’06 will be// observed as Oral Health Month. Now ... an intensive month-long oral health awareness campaign in India ... health habits for all ages. This year, the theme ...
... of cheese on the pizza melts away in your mouth, ... that are packed in this delicious spread.// A novel study ... size, misjudge the calorie content of fast-food meals. Although the ... the study revealed. ,Pierre Chandon, a co-author ...
... is improving, but the chasm between the rich and poor ... average life expectancy of a Scottish woman to be around ... to reach 74 years of age. , ,A ... expectancy for Scotland's council and health board areas is improving ...
Cached Medicine News:Health News:Military Hospitals Need To Be Prepared To Treat Children 2Health News:Striving to Make India Free from Tooth Decay 2
... The Sysmex pocH-100i is the first Sysmex ... low daily testing requirements. With its small ... differential from just 15 L of whole ... any small healthcare site including the emergency ...
... a self-contained, compact, easy-to-use, bedside automated cell ... Ichor system provides a hematology profile of ... platelet aggregation within five minutes. The test ... is added to both an EDTA baseline ...
... pacemaker family, which includes the world's ... the most advanced pacemaker technology available, ... the first and only U.S. commercially ... fibrillation (AF). The AF Suppression algorithm ...
... catheters that are controlled by an ... console processes the refrigerant, which when ... the catheter, creates cryogenic temperatures., ,The ... touch-screen interface. From this interface, the ...
Medicine Products: