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35th ESMO Congress: Milan, Italy (FieraMilanoCity), 8-12 October 2010 - Press Programme Curtain Raiser

the way Phase-I and Phase-II cancer clinical trials are designed. Researchers report finding unexpectedly large differences in the lists of drugs that trial designers say participants should not be given to avoid potentially dangerous drug-drug interactions.

T. Mok, CN

New Phase-II study shows first-line promise of lung cancer drug PF-299 (embargo: 11 October, 13:15 Milan time)

A new-generation lung cancer drug has shown an impressive ability to prevent disease progression when administered as a first-line treatment in patients with advanced disease.

A. Necchi, IT

Pazopanib shows promise in Phase-II trial for relapsed/refractory urothelial cancer (embargo: 11 October, 13:30 Milan time)

An ongoing Phase-II trial investigating a new, targeted therapy for metastatic urothelial cancer has generated promising early results.

J. Vermorken, NL

Panitumumab fails to add overall survival benefit in recurrent/metastatic head and neck cancer: full Phase-III results (embargo: 11 October, 13:30 Milan time)

Adding the monoclonal anti-EGFR antibody panitumumab to chemotherapy did not significantly improve overall survival for patients with recurrent and/or metastatic head and neck cancer, according to Phase-III trial results.

J. Baselga, US

Adding cetuximab to chemotherapy doubles response rate in hard-to-treat breast cancer (embargo: 11 October, 15:00 Milan time)

For the first time researchers have proven that targeting the epidermal growth factor receptor can provide substantial clinical benefit for women with hard-to-treat "triple negative" breast cancer.

E. Perez, US

New type of targeted therapy shows promise as first-line therapy for HER2-positive metastatic breast cancer (embargo: 11 October, 15:00 Milan time)

A new type of breast cancer treatment has shown encouraging activity as a first-line therapy in HER2-positive metastatic disease.

J. De Bono,

SOURCE European Society for Medical Oncology (ESMO)
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