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3-V Biosciences Presents Positive Data for Novel FASN Inhibitor at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
Date:10/21/2013

TVB-2640, is one of a series of FASN inhibitors initially being developed by 3-V to treat solid tumor cancers by inhibiting key metabolic and signaling pathways associated with tumor growth and proliferation.  FASN activity promotes the tumorigenic potential of cells as part of tumor cell metabolism, which in turn provides fuel required by rapidly proliferating cancer cells.  FASN over-expression is associated with aggressive disease and poor prognosis in a number of cancers.

3-V has filed an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) and plans to initiate first-in-human studies of TVB-2640 by the end of 2013.

Data for 3-V's FASN tumor metabolism inhibitors was presented during the Therapeutic Agents: session of the Molecular Targets and Cancer Therapeutics meeting on Monday at 12:30 pm ET in a poster titled "Characterization of small-molecule FASN inhibitors in preclinical tumor models" (Abstract #B261)

About 3-V Biosciences
3-V Biosciences, Inc. is a privately held biopharmaceutical company discovering and developing therapeutics that modulate key pathways in oncology and infectious disease. In oncology, the company's lead candidate is a fatty acid synthase (FASN) inhibitor that blocks tumor cell signaling pathways and induces tumor cell apoptosis. 3-V's antiviral therapeutics block host-pathogen interactions, resulting in robust and broad-spectrum antiviral activity, including efficacy against viruses resistant to other classes of antiviral drugs, and a high barrier to resistance. The
3-V team applies an integrated approach, leveraging internal expertise in biology, medicinal chemistry, drug discovery and development to drive programs forward. The company is located in Menlo Park, California.

For additional information on 3-V Biosciences, please visit www.3vbio.com.

 

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SOURCE 3-V Biosciences, Inc.
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