Navigation Links
3-V Biosciences Presents Positive Data for Novel FASN Inhibitor at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
Date:10/21/2013

MENLO PARK, Calif., Oct. 21, 2013 /PRNewswire/ -- 3-V Biosciences, Inc., a biopharmaceutical company developing therapeutics that modulate key host-cell pathways resulting in death of tumor cells or virally-infected cells, today presented positive data from preclinical studies of the company's novel fatty acid synthase (FASN) inhibitors. 

(Logo: http://photos.prnewswire.com/prnh/20121001/LA83573LOGO )

In a series of preclinical studies, 3-V's FASN inhibitors demonstrated potent activity against multiple tumor types, including breast, lung, pancreatic, ovarian and colon cancers.  FASN inhibition reduced cell proliferation and induced apoptosis (cell death) in a dose-dependent manner.  Of note, single-agent FASN inhibition both blocked tumor growth and resulted in significant tumor regression in patient-derived xenografts.  FASN inhibition was well tolerated at dose levels that achieved potent anti-cancer effect. 

"Our novel FASN inhibitor molecules demonstrate strong single-agent anti-cancer activity in vivo, and we are excited by the potential of these drugs to halt tumor growth and progression," said Merdad Parsey, M.D., Ph.D., Chief Executive Officer of 3-V Biosciences.  "FASN is a highly attractive target in oncology, but prior inhibitor programs have been challenged in aligning therapeutic efficacy with tolerability.  3-V's preclinical studies characterizing our FASN inhibitors point to a number of critical attributes, including potent tumor cell growth inhibition across a number of tumor types and a promising tolerability profile that should enable use in combination with standard of care.  We are ready to commence a Phase 1 clinical study for our lead candidate, TVB-2640, this year in patients with advanced solid tumors."

The company's lead clinical candidate, TVB-2640, is one of a series of FASN inhibitors initially being developed by 3-V to treat solid tumor cancers by inhibiting key metabolic and signaling pathways associated with tumor growth and proliferation.  FASN activity promotes the tumorigenic potential of cells as part of tumor cell metabolism, which in turn provides fuel required by rapidly proliferating cancer cells.  FASN over-expression is associated with aggressive disease and poor prognosis in a number of cancers.

3-V has filed an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) and plans to initiate first-in-human studies of TVB-2640 by the end of 2013.

Data for 3-V's FASN tumor metabolism inhibitors was presented during the Therapeutic Agents: session of the Molecular Targets and Cancer Therapeutics meeting on Monday at 12:30 pm ET in a poster titled "Characterization of small-molecule FASN inhibitors in preclinical tumor models" (Abstract #B261)

About 3-V Biosciences
3-V Biosciences, Inc. is a privately held biopharmaceutical company discovering and developing therapeutics that modulate key pathways in oncology and infectious disease. In oncology, the company's lead candidate is a fatty acid synthase (FASN) inhibitor that blocks tumor cell signaling pathways and induces tumor cell apoptosis. 3-V's antiviral therapeutics block host-pathogen interactions, resulting in robust and broad-spectrum antiviral activity, including efficacy against viruses resistant to other classes of antiviral drugs, and a high barrier to resistance. The
3-V team applies an integrated approach, leveraging internal expertise in biology, medicinal chemistry, drug discovery and development to drive programs forward. The company is located in Menlo Park, California.

For additional information on 3-V Biosciences, please visit www.3vbio.com.

 

Contact information

Merdad Parsey, M.D., Ph.D.
Chief Executive Officer
650-561-8600

Media Inquiries

BCC Partners on behalf of 3-V Biosciences, Inc.
Karen L. Bergman
650-575-1509
kbergman@bccpartners.com
Michelle Corral
415-794-8662
mcorral@bccpartners.com


'/>"/>
SOURCE 3-V Biosciences, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Pressure BioSciences, Inc. and Target Discovery, Inc. Expand Strategic License Agreement and Collaboration Supporting TDIs Planned Offering of Personalized Medicine Clinical Diagnostic Services
2. Neurocrine Biosciences Announces Conference Call and Webcast to Present First Quarter 2012 Financial Results
3. Amarantus BioSciences to Present at the New York Biotechnology Association (NYBA) 21st Annual Meeting on May 2nd, 2012
4. Neurocrine Biosciences Reports First Quarter 2012 Results
5. Pressure BioSciences, Inc. to Discuss First Quarter 2012 Financial Results And Provide Business Update
6. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
7. Neurocrine Biosciences to Present at the Jefferies 2012 Global Healthcare Conference
8. 3-V Biosciences To Present at the Seventh Annual JMP Securities Healthcare Conference
9. Sofie Biosciences receives $1M Phase II SBIR grant from the DOE
10. Frost & Sullivan 2012 New Product Innovation in Bioanalytics Awarded to Protea Biosciences
11. Pressure BioSciences Patented PCT Platform Shown to Significantly Improve Protein and DNA Detection in Multiple Studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... , 11 de fevereiro de 2016  A ... sua fábrica de soroalbumina bovina (BSA -- ... fábrica fica na Ilha Norte da Nova Zelândia, ... e estabelecido na fábrica da Proliant nos EUA, ... O projeto e instalação dos equipamentos foram feitos ...
(Date:2/11/2016)... February 11, 2016 Breast Cancer Therapeutics ... Asia-Pacific (APAC) breast cancer market will ... billion by 2021, at a Compound Annual Growth Rate (CAGR) ... Markets to 2021 - states that the ... expansion from $1.9 billion in 2014 to $3.4 billion by ...
(Date:2/11/2016)... , February 11, 2016 ... at Worldwide Clinical Trials, will present at this year,s Summit ... the Hyatt Regency in Miami, FL. ... partnerships to optimize study execution, supporting SCOPE,s "Improving Site Study ... take place on Thursday, Feb. 25 at 11:05 a.m. ...
Breaking Medicine Technology:
(Date:2/11/2016)... ... February 11, 2016 , ... ... a master charity program created to assist the people of their local community. ... with nonprofit organizations and community leaders. Their hope is to bring awareness to ...
(Date:2/11/2016)... ... February 11, 2016 , ... Duterte Insurance Group, serving the ... a new charity campaign to raise funds for Ronald McDonald House Charities. On ... https://donate.rmhc.org/ . , Ronald McDonald House (RMH) is an internationally renowned nonprofit organization ...
(Date:2/11/2016)... VA (PRWEB) , ... February 11, 2016 , ... ... its new office in the heart of Old Town at 108 South Columbus St, ... and businesses the highest level of medical care in the convenience of their homes, ...
(Date:2/11/2016)... Denver, CO. (PRWEB) , ... February 11, 2016 ... ... American people have become more actively engaged in health and wellness best practices ... the importance of riding this trend. February is American Heart Month, which acts ...
(Date:2/10/2016)... ... 10, 2016 , ... President Obama’s budget proposal yesterday enables ... medical services via telehealth, estimated to generate more than $160 million in savings ... many years. Although there is more to be done, this represents an ...
Breaking Medicine News(10 mins):