Navigation Links
3-V Biosciences Presents Positive Data for Novel FASN Inhibitor at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

MENLO PARK, Calif., Oct. 21, 2013 /PRNewswire/ -- 3-V Biosciences, Inc., a biopharmaceutical company developing therapeutics that modulate key host-cell pathways resulting in death of tumor cells or virally-infected cells, today presented positive data from preclinical studies of the company's novel fatty acid synthase (FASN) inhibitors. 

(Logo: )

In a series of preclinical studies, 3-V's FASN inhibitors demonstrated potent activity against multiple tumor types, including breast, lung, pancreatic, ovarian and colon cancers.  FASN inhibition reduced cell proliferation and induced apoptosis (cell death) in a dose-dependent manner.  Of note, single-agent FASN inhibition both blocked tumor growth and resulted in significant tumor regression in patient-derived xenografts.  FASN inhibition was well tolerated at dose levels that achieved potent anti-cancer effect. 

"Our novel FASN inhibitor molecules demonstrate strong single-agent anti-cancer activity in vivo, and we are excited by the potential of these drugs to halt tumor growth and progression," said Merdad Parsey, M.D., Ph.D., Chief Executive Officer of 3-V Biosciences.  "FASN is a highly attractive target in oncology, but prior inhibitor programs have been challenged in aligning therapeutic efficacy with tolerability.  3-V's preclinical studies characterizing our FASN inhibitors point to a number of critical attributes, including potent tumor cell growth inhibition across a number of tumor types and a promising tolerability profile that should enable use in combination with standard of care.  We are ready to commence a Phase 1 clinical study for our lead candidate, TVB-2640, this year in patients with advanced solid tumors."

The company's lead clinical candidate, TVB-2640, is one of a series of FASN inhibitors initially being developed by 3-V to treat solid tumor cancers by inhibiting key metabolic and signaling pathways associated with tumor growth and proliferation.  FASN activity promotes the tumorigenic potential of cells as part of tumor cell metabolism, which in turn provides fuel required by rapidly proliferating cancer cells.  FASN over-expression is associated with aggressive disease and poor prognosis in a number of cancers.

3-V has filed an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) and plans to initiate first-in-human studies of TVB-2640 by the end of 2013.

Data for 3-V's FASN tumor metabolism inhibitors was presented during the Therapeutic Agents: session of the Molecular Targets and Cancer Therapeutics meeting on Monday at 12:30 pm ET in a poster titled "Characterization of small-molecule FASN inhibitors in preclinical tumor models" (Abstract #B261)

About 3-V Biosciences
3-V Biosciences, Inc. is a privately held biopharmaceutical company discovering and developing therapeutics that modulate key pathways in oncology and infectious disease. In oncology, the company's lead candidate is a fatty acid synthase (FASN) inhibitor that blocks tumor cell signaling pathways and induces tumor cell apoptosis. 3-V's antiviral therapeutics block host-pathogen interactions, resulting in robust and broad-spectrum antiviral activity, including efficacy against viruses resistant to other classes of antiviral drugs, and a high barrier to resistance. The
3-V team applies an integrated approach, leveraging internal expertise in biology, medicinal chemistry, drug discovery and development to drive programs forward. The company is located in Menlo Park, California.

For additional information on 3-V Biosciences, please visit


Contact information

Merdad Parsey, M.D., Ph.D.
Chief Executive Officer

Media Inquiries

BCC Partners on behalf of 3-V Biosciences, Inc.
Karen L. Bergman
Michelle Corral

SOURCE 3-V Biosciences, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Pressure BioSciences, Inc. and Target Discovery, Inc. Expand Strategic License Agreement and Collaboration Supporting TDIs Planned Offering of Personalized Medicine Clinical Diagnostic Services
2. Neurocrine Biosciences Announces Conference Call and Webcast to Present First Quarter 2012 Financial Results
3. Amarantus BioSciences to Present at the New York Biotechnology Association (NYBA) 21st Annual Meeting on May 2nd, 2012
4. Neurocrine Biosciences Reports First Quarter 2012 Results
5. Pressure BioSciences, Inc. to Discuss First Quarter 2012 Financial Results And Provide Business Update
6. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
7. Neurocrine Biosciences to Present at the Jefferies 2012 Global Healthcare Conference
8. 3-V Biosciences To Present at the Seventh Annual JMP Securities Healthcare Conference
9. Sofie Biosciences receives $1M Phase II SBIR grant from the DOE
10. Frost & Sullivan 2012 New Product Innovation in Bioanalytics Awarded to Protea Biosciences
11. Pressure BioSciences Patented PCT Platform Shown to Significantly Improve Protein and DNA Detection in Multiple Studies
Post Your Comments:
(Date:10/9/2015)... , October 9, 2015 ... major players. --> India ... --> announces addition of 3 divalproex ... 2020 forecasts for global markets as well as ... along with analysis of major players. ...
(Date:10/9/2015)... 9, 2015  The Centers for Disease Control ... and Zoonotic Infectious Diseases, Office of Advanced Molecular ... a research collaboration to evaluate the performance of ... this research collaboration is to evaluate the utility ... health and infectious disease applications. This collaboration will ...
(Date:10/9/2015)... ClinicalKey Nursing debuts at ...   Elsevier , a world-leading provider of ... ClinicalKey for Nursing , a new clinical reference platform ... unique needs of nursing professionals. Attendees of the ANCC ... Oct. 7-9, will have the opportunity to demo ClinicalKey Nursing ...
Breaking Medicine Technology:
... plan for various study outcomes, MEXICO CITY, Aug. ... a new report, Anticipating the Results of PrEP,Trials, calling ... and advocates to prepare for initial,results - expected as ... drugs being tested for HIV prevention, known as PrEP ...
... is pleased,to announce the dosing of the first patient ... of AEG35156, a second generation antisense,therapeutic targeting XIAP, a ... The study, made possible, in part, by funding from ... Multicenter, Open-Label Study,of the X- Linked Inhibitor of Apoptosis ...
Cached Medicine Technology:
(Date:10/9/2015)... ... October 09, 2015 , ... ... welcoming individuals from all walks of life to save money on the high ... of $25 per month per medication, individuals and families can receive their medications ...
(Date:10/9/2015)... ... October 09, 2015 , ... ViewPoint Center, a teen mental health hospital ... mental illness, the stigma associated with mental illness causes many to hide away in ... importance of supporting teens with mental illness , providing teens with comprehensive diagnostic ...
(Date:10/9/2015)... Colorado (PRWEB) , ... October 09, 2015 , ... ... Station, one of the oldest and largest recreational dispensaries in Colorado, says the ... cannabis business is growing rapidly and maturing into a legitimate industry. , ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... ... assisted living placement counseling, recently opened its newest office in Maryland – its ... care industry with a background as a project management technology consultant to many ...
(Date:10/9/2015)... ... ... Smanos was featured on NewsWatch as part of its monthly Tech Report, which features ... and special reporter for NewsWatch, conducted the review and shared with viewers how this ... age it’s more important than ever to keep homes and dorms safe and protected. ...
Breaking Medicine News(10 mins):
... of infamous psychological obedience study in 1960s , , MONDAY, ... as willing to follow orders to hurt others as they ... , In a replication of one of the most famous ... give what they believed were increasingly painful electric shocks to ...
... , WHAT: YEAR-IN-PREVIEW WEBINAR ... Wednesday, January 7, 2009 11:00 AM (U.S. Eastern Time) ... ENROLL: Please use the link below to register ... Millennium Research Group (MRG) complimentary webinar identifying the top 10 ...
... will be the subject of a policy forum sponsored ... January 13, 2009, from 3:00 p.m. until 4:30 p.m. ... Suites Resort, 5001 N. Scottsdale Road, Scottsdale, Arizona. This ... explore the relationship between health insurance coverage and access ...
... Mo., Jan. 5 The recent tragic death of Jett ... which he was diagnosed in early childhood. Kawasaki disease is ... the age of five. The disease occurs more often in ... and Korean descent. Although most children diagnosed with Kawasaki recover ...
... AUGUSTA, Ga. Just days after the first retinal ... start committing suicide and researchers believe their death may ... infection. , Understanding the cell death may also provide ... retina responds to assault, whether by infection or a ...
... WASHINGTON, Jan. 5 Despite a deepening recession, only ... raise less money this year than in 2008 said ... services for the poor and underinsured, according to a ... Philanthropy ( ).The overwhelming majority of AHP members ...
Cached Medicine News:
Incontinence Pessaries...
Incontinence Dish - Stress Incontinence with mild prolapse. Incontinence Dish with support - Stress Incontinence with mild prolapse and mild cystocele...
The Set comes with a cross reference chart that translates ring size into the correct size of other EvaCare pessaries. The Fitting Set can be disinfected in three ways: autoclaved, boiled or cold ste...
The donut pessary is designed for third degree prolapse as well as cystocele and rectocele. The soft donut can be compressed for insertion. It is available in seven sizes....
Medicine Products: