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18 month Follow-up Data on Phase III Study of Pixantrone in Late Stage Relapsed or Refractory, Aggressive Non-Hodgkin's Lymphoma Continues to Demonstrate Significant Improvement in Complete Remission and Progression Free Survival Over Standard Chemotherap
Date:9/15/2009

SEATTLE, Sept. 16 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) today released updated 18-month follow-up clinical data for its phase III EXTEND (PIX 301) trial of pixantrone (BBR2778) for patients with advanced, relapsed or refractory, aggressive non-Hodgkin's lymphoma (NHL). Responses were evaluated by an Independent Assessment Panel that was blinded to patient assignment.

The table below shows the primary end of treatment data analyses previously reported and the new updated 18 month efficacy data analyses. This data is part of CTI's presentation today at the BioCentury NewsMakers conference at 10:30 AM ET.

                 End of Treatment      18 Month Follow-Up
                 ----------------      ------------------
                 CR/CRu                CR/CRu
                 ----------------      ------------------
    Pixantrone   20.0%                 25.7%
    Control       5.7%                  7.1%
    P Value       0.021                 0.005

                 ORR                   ORR
                 ----------------      ------------------
    Pixantrone   37.1%                 40.0%
    Control      14.3%                 14.3%
    P Value       0.003                 0.001

                 End of Treatment      18 Month Follow-Up
                 ----------------      ------------------
                 Progression Free      Progression Free
                 Survival              Survival
                 ----------------      ------------------
    Pixantrone   4.7 months            5.6 months
    Control      2.6 months            2.6 months
    P Value      0.007 (HR = 0.60)     0.002 (HR = 0.56)

                 Median Overall        Median Overall
                 Survival              Survival
                 ----------------      ------------------
    Pixantrone   8.1 months            10.2 month
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SOURCE Cell Therapeutics, Inc.
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