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12 Month Follow-Up Data for Isotope-Free Breast IORT Presented at ASBS Meeting
Date:4/28/2010

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"In addition to the potential clinical benefits, from a patient's perspective the nominal extra time spent by the radiation oncologist and surgeon in the OR will negate the often difficult logistics of WBRT or APBI," added Dr. Ivanov.  "The use of IORT may also obviate the need for mastectomy in patients who cannot travel to a radiation treatment center for therapy where it has been shown that an increase in travel distance to a radiation facility decreases the chances of a woman receiving treatment.  In one study only 51% of women completed prescribed therapy if they lived more than 75 miles from the radiation facility."

IORT is a radiation therapy technique where a concentrated dose of radiation is delivered to a cancerous tumor site during surgery after the tumor is removed.  Because the target and normal tissues can be clearly identified during surgery, IORT may increase targeting accuracy, thereby increasing dose to the target and reducing dose to critical structures. For breast IORT, the shorter treatment time is generally more convenient for patients than the seven-week course of external beam-therapy, and may increase patient compliance.

The Xoft eBx System uses a miniaturized X-ray source instead of a radioactive isotope to deliver radiation to the breast from within a balloon catheter. The low energy and rapid dose fall-off of the electronic source permit treatment in typical operating rooms, with minimal shielding required. Lightweight and mobile, the system can be moved easily between multiple ORs.

Available for treatment of early stage breast cancer, endometrial cancer, and skin cancer, the Axxent eBx System is also FDA-cleared for IORT (intra-operative radiation therapy). As a platform technology, the Axxent System is designed to deliver non-radioactive therapy directly to cancer sites with minimal radiation
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SOURCE Xoft, Inc.
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