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Unconjugated Estriol, Ultra-Sensitive RIA Test

ProductsUnconjugated Estriol, Ultra-Sensitive RIA Test
Company Diagnostic Systems Laboratories, Inc.
Item Unconjugated Estriol, Ultra-Sensitive RIA Test
Description Estriol (E3) is one of the 3 major naturally occurring estrogens (the others being estradiol and estrone). In terms of estrogenic activity, estriol is much less potent than estradiol [1]. Estriol is produced almost exclusively during pregnancy, and is the major estrogen produced in the normal human fetus. During pregnancy, the production of estriol depends on an intact maternal-placental-fetal unit [1,2]. Fetal-placental production of estriol leads to a progressive rise in maternal circulating estriol levels, reaching a late-gestational peak which is ~2-3 orders of magnitude greater than non-pregnant levels [1,2]. In the maternal circulation, estriol undergoes rapid conjugation in the liver followed by urinary excretion with a half-life of ~20 minutes [2]. Since normal estriol production depends on an intact maternal-placental-fetal circulation and functional fetal metabolism, maternal estriol levels have been used to monitor fetal status during pregnancy, particularly during the third trimester. Deteriorating fetoplacental health in the third trimester is often associated with falling unconjugated maternal serum estriol levels [3].

  1. Ca ez MS, et al. Infertil Reproduct Med Clin North Amer 3:59-78, 1992.
  2. Buster JE. Clin Perinatol 10:527-552, 1983.
  3. Norman AW & Litwack G: Hormones. Academic Press, San Diego, 1987
Info Diagnostic Systems Laboratories, Inc.
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